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Scientists discover genetic markers for mosquito resistance to insecticides

Controlling mosquitoes that carry human diseases is a global health challenge as their ability to resist insecticides now threatens efforts to prevent epidemics. Scientists from the CNRS, IRD, Université Claude Bernard Lyon 1, Université Joseph Fourier in Grenoble and Institut Pasteur in French Guiana have identified new genetic markers for mosquito resistance to insecticides, which could improve its detection in the field.

24 Jul 2015

Retail meat harbors disease-causing Klebsiella pneumoniae, shows new study

Chicken, turkey and pork sold in grocery stores harbors disease-causing bacteria known as Klebsiella pneumoniae, according to a new study. The research, which was published online today in the journal Clinical Infectious Diseases, shows that contaminated meat may be an important source of human exposure to Klebsiella.

23 Jul 2015

Infants born with mutation in PLVAP gene develop severe protein losing enteropathy

Newborn children born with a mutation in the Plasmalemma Vesicle Associated Protein (PLVAP) gene develop severe protein losing enteropathy, according to a case study1 published in Cellular and Molecular Gastroenterology and Hepatology, the basic science journal of the American Gastroenterological Association.

23 Jul 2015

TGen, NAU to jointly develop quick, affordable and accurate test to diagnose Lyme disease

Focus On Lyme, an initiative sponsored by the Leadership Children's Foundation of Gilbert, Ariz., has donated $75,000 to the Translational Genomics Research Institute to support research into the development of a quick, affordable and accurate method of diagnosing Lyme disease.

21 Jul 2015

Study stresses importance of investigating telomeres to improve diagnoses, develop treatments for many diseases

Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to ageing been confirmed; defective telomeres seem to be linked to more and more illnesses, including many types of cancer.

16 Jul 2015

Noninvasive prenatal screening could detect maternal cancer

A study published today in the Journal of the American Medical Association shows that genetic test results, as revealed by non-invasive prenatal testing for fetal chromosome abnormalities, may detect underlying conditions in the mother, including cancer.

15 Jul 2015

UA researchers awarded NIH grant to develop software that lets doctors analyze digitized biomedical data

The National Institutes of Health has awarded a $1.3 million grant to researchers at the University of Arizona to develop open-source software that will enable health care professionals and scientists to manage biomedical big data in digital form.

10 Jul 2015

LSD1 enzyme turns off genes needed to maintain cancer stem cell properties in glioblastoma

Cancer's ability to grow unchecked is often attributed to cancer stem cells, a small fraction of cancer cells that have the capacity to grow and multiply indefinitely. How cancer stem cells retain this property while the bulk of a tumor's cells do not remains largely unknown. Using human tumor samples and mouse models, researchers at University of California, San Diego School of Medicine and Moores Cancer Center discovered that cancer stem cell properties are determined by epigenetic changes -- chemical modifications cells use to control which genes are turned on or off.

7 Jul 2015

WPI-led study provides clues to new ways to treat difficult-to-cure fungal infections

A study by a multidisciplinary research team, co-directed by Worcester Polytechnic Institute, offers new insights into how virulent fungi adapt through genetic modifications to fight back against the effects of medication designed to block their spread, and how that battle leaves them temporarily weakened. These insights may provide clues to new ways to treat notoriously difficult-to-cure fungal infections like thrush and vaginitis.

7 Jul 2015

Penn study suggests future precision medicine approach to treating diabetes, other metabolic disorders

In the first study of its kind, Penn researchers have shown how an anti-diabetic drug can have variable effects depending on small natural differences in DNA sequence between individuals. Mitchell Lazar, MD, PhD, Raymond Soccio, MD, PhD, and colleagues at the Perelman School of Medicine at the University of Pennsylvania, aim to apply this knowledge to develop personalized approaches to treating diabetes and other metabolic disorders.

3 Jul 2015

BGI's DNA sequencing laboratory in Hong Kong accredited by CAP

BGI announced today that its high-throughput DNA sequencing laboratory in Hong Kong has been accredited by the American College of Pathologists. The BGI Hong Kong facility is the first clinical next-generation-sequencing laboratory to receive the CAP certification in China, meeting the highest standard in clinical laboratory practices.

2 Jul 2015

Study of genetic mutations could lead to optimized treatment plans for aplastic anemia patients

Scientists have identified a group of genetic mutations in patients with aplastic anemia, which likely will help doctors optimize treatment for this rare and deadly blood condition. The study, appearing in the New England Journal of Medicine, could lead to tailor-made treatment plans for aplastic anemia patients as part of the emerging precision medicine movement.

2 Jul 2015

UVA Health System opens high-tech clinical genomics lab

The University of Virginia Health System has opened a high-tech clinical genomics lab that will personalize care for patients, help doctors determine the best treatments for cancers and other diseases, and allow UVA to offer the most cutting-edge clinical trials.

1 Jul 2015

Multiple courses of antibiotics may have significant impact on child development

A new animal study by NYU Langone Medical Center researchers adds to growing evidence that multiple courses of commonly used antibiotics may have a significant impact on children's development.

1 Jul 2015

Imperial College London researchers discover new inherited form of obesity, type 2 diabetes

Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans. A large number of genes are involved in regulating body weight, and there are now over 30 genes known in which people with harmful changes in DNA sequence become extremely overweight. Similarly, there are a number of genes that can, when altered, cause type 2 diabetes. These conditions are inherited through families in exactly the same way as disorders such as cystic fibrosis or Huntington's disease.

30 Jun 2015

Scientists develop high-throughput strategy to build de novo genomes

Scientists from the Icahn School of Medicine at Mount Sinai have developed a new approach to build nearly complete genomes by combining high-throughput DNA sequencing with genome mapping. The methodology enabled researchers to detect complex forms of genomic variation, critically important for their association with human disease, but previously difficult to detect.

30 Jun 2015

NIDA announces recipients of Avenir Award programs for HIV/AIDS, genetics or epigenetics research

The National Institute on Drug Abuse today announced the first six recipients of its two newly developed Avenir Award programs for HIV/AIDS and genetics or epigenetics research. The Avenir (meaning "future" in French) Awards support early stage investigators who propose highly innovative studies. The six scientists will each receive up to $300,000 per year for five years to support their research.

27 Jun 2015

SeraCare Life Sciences inks CRADA with NCI to create positive controls for cancer assays

SeraCare Life Sciences, a leading partner to global in vitro diagnostics manufacturers, today announced that it has signed a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute, part of the National Institutes of Health, to create reference materials and positive controls for cancer assays.

26 Jun 2015

Analysis of ancient DNA shows that Kennewick Man more closely related to Native Americans

DNA from the 8,500-year-old skeleton of an adult man found in 1996, in Washington, is more closely related to Native American populations than to any other population in the world, according to an international collaborative study conducted by scientists at the University of Copenhagen and the Stanford University School of Medicine.

19 Jun 2015

HUJI professor honored with Helmholtz International Fellow Award for epigenetics research

The Israeli immunologist and cancer researcher Professor Yehudit Bergman of the Hebrew University of Jerusalem, Israel, has been honored with the Helmholtz International Fellow Award for her excellent research. In a prize ceremony at the MDC Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin, Germany, MDC's interim director Professor Thomas Sommer presented the certificate to her on Thursday, June 18th, 2015.