Glioblastoma News and Research

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Glioblastoma is the most aggressive and malignant form of glioma, a type of primary brain cancer. Surgery is often used to treat gliomas, along with radiation. However, since surgery and radiation fail to cure the disease, doctors may turn to additional radiation or chemotherapy. In early stages glioblastoma tumors often grow without symptoms and therefore can become quite large before symptoms arise. When the tumor becomes symptomatic, tumor growth is usually very rapid and is accompanied by altered brain function, and if left untreated the disease becomes lethal. Although primary treatment is often successful in temporarily stopping the progression of the tumor, glioblastomas almost always recur and become lethal.

Zika virus could be alternative for treatment of aggressive brain cancer

Zika virus, feared for causing microcephaly in babies whose mothers were infected during pregnancy by attacking the cells that will give rise to the fetus's cerebral cortex, could be an alternative for treatment of glioblastoma, the most common and aggressive kind of malignant brain tumor in adults.

21 Feb 2018

Research project aims to find new ways to identify and treat most aggressive brain cancers

A large European research collaboration is bringing new technology to bear to combat two of the most aggressive brain cancers.

21 Feb 2018

New study to test safety, efficacy of MRI-guided focused ultrasound to treat Parkinson's disease

University of Maryland Medicine is leading a phase 3 study to test the safety and efficacy of using MRI-guided focused ultrasound on the brain in order to treat Parkinson's disease.

13 Feb 2018

Undergraduate researcher discovers genes linked to glioblastoma

When Leland Dunwoodie, an undergraduate researcher in biochemistry, approached his PI about wanting to start research on "some human stuff" in the spring of 2016, he didn't imagine it would lead to the discovery of 22 genes that are implicated in glioblastoma, the most aggressive type of brain cancer.

9 Feb 2018

Researchers devise strategies to target glioma stem cells that could improve patient survival

Glioblastoma multiforme is the most common and aggressive primary brain tumor and has one of the worst survival rates of all cancers.

5 Feb 2018

New study sheds light on important protein involved in memory formation

A team of researchers have made important discoveries about a protein called AKT that is key to the formation of new memories.

29 Jan 2018

Study sheds light on key protein involved in memory formation and brain growth

Ask a nonscientist what memories are made of and you'll likely conjure images of childhood birthday parties or wedding days. Charles Hoeffer thinks about proteins.

27 Jan 2018

Enzyme inhibitor and chemotherapy combination regresses glioblastoma

In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.

24 Jan 2018

Combination chemotherapy increases survival in animal models of glioblastoma

A diagnosis of the brain cancer glioblastoma carries a dismal prognosis, with most patients dying within five years.

23 Jan 2018

Researchers block common siren call of glioblastoma and metastatic breast cancer

Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

23 Jan 2018

Circadian rhythms could hold key to novel treatments for glioblastoma

Biological clocks throughout the body play a major role in human health and performance, from sleep and energy use to how food is metabolized and even stroke severity.

10 Jan 2018

Nanobiotix receives FDA approval for first immuno-oncology trial

NANOBIOTIX, a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the U.S. Food and Drug Administration has approved its Investigational New Drug Application for NBTXR3, a first-in-class nanoparticle designed for direct injection into cancerous tumors, activated by stereotactic ablative radiotherapy (SABR) and administered in combination with an anti-PD1 antibody (nivolumab or pembrolizumab).

26 Dec 2017

Higher ‘mutational burden’ of tumors predicts success rate with cancer immunotherapies

The "mutational burden," or the number of mutations present in a tumor's DNA, is a good predictor of whether that cancer type will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows.

21 Dec 2017

Certain brain tumor patients more likely to receive short hospice services, study finds

While more than 60 percent of patients with the brain tumors called malignant gliomas enroll in hospice services, almost a quarter of them do so within a week of death, probably too late for patients and family members to benefit from hospice care.

20 Dec 2017

New scalp device delivering electric fields improves survival in patients with glioblastoma

A device attached to a patient's scalp that delivers a continuous dose of low-intensity electric fields improves survival and slows the growth of a deadly brain tumor, according to a new clinical trial led by a Northwestern Medicine scientist and published Dec. 19 in the journal JAMA.

19 Dec 2017

Electric fields therapy leads to better overall, progression-free survival in glioblastoma patients

Patients with glioblastoma, an aggressive brain tumor who received a type of electric fields therapy that interferes with cell division had better overall survival and survival without progression of the tumor compared to standard chemotherapy.

19 Dec 2017

Researchers identify novel mechanism that protects from brain tumor

A group of researchers at the Spanish National Cancer Research Centre have identified a protein called RanBP6 as a new regulator of EGFR. In a paper published in Nature Communications they show how silencing of RanBP6 promoted glioma growth, by upregulating EGFR expression.

18 Dec 2017

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