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Early treatment with interferons could mitigate severe COVID-19 in people with specific genetic factors

Researchers from the National Cancer Institute, part of the National Institutes of Health, and their collaborators have discovered that people of European and African ancestries who were hospitalized for COVID-19 are more likely to carry a particular combination of genetic variants in a gene known as OAS1 than patients with mild disease who were not hospitalized.

14 Jul 2022

Antibody signatures strongly associated with SARS-CoV-2 immunopathology identified using a novel B cell epitope discovery method

A recent study discovered antibody footprints strongly correlated with immunopathology of SARS-CoV-2 infection using a new B cell epitope identification approach

14 Jul 2022

The interaction between SARS-CoV-2 and influenza A during coinfection

Researchers assessed the host response to influenza A and COVID-19 during coinfection.

14 Jul 2022

Persistence of SARS-CoV-2 in tissues leads to long COVID

PASC is likely the result of long-term persistence of SARS-CoV-2 in various tissues

11 Jul 2022

Activation of the STING pathway could help make glioblastoma multiforme more susceptible to immunotherapy

Immunotherapy has revolutionized treatment for many forms of cancer, but glioblastoma multiforme (GBM), the most common and deadly form of brain cancer, has remained untouched.

11 Jul 2022

After 3 doses of COVID vaccine, most cancer patients retain detectable humoral immunity

In a recent study posted to the medRxiv* preprint server, researchers assessed the efficacy and durability of immune responses to the third dose of coronavirus disease 2019 (COVID-19) vaccines. They also assessed the efficacy of the fourth vaccine dose among severely immunocompromised patients with hematological malignancies.

7 Jul 2022

Human milk immune activity may both lower and increase infants’ infectious disease risk

Researchers discuss the short-term effects of the immune system of breast milk on infant health.

7 Jul 2022

What role does human microbiota play in COVID-19 severity?

In a recent study published in the journal Advanced Science, researchers explored the dynamic changes in the respiratory tract and gut microbiota in coronavirus disease 2019 (COVID-19) patients. They observed and analyzed these changes during different disease progression stages among patients with differential disease severities.

5 Jul 2022

Vitamin D protects against H1N1 and SARS-CoV-2 infection in mice

Vitamin D supplementation reduces inflammation, after H1N1 and SARS-CoV-2 infections in mice.

5 Jul 2022

Brain immune response to SARS-CoV-2 infection

In a recently published article in the journal Current Opinion in Neurobiology, scientists at Washington University School of Medicine, St. Louis have described how immunological alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may impact brain activities and induce acute and post-acute neurological symptoms in coronavirus disease 2019 (COVID-19) patients.

3 Jul 2022

Study evaluates if adults with obesity and a history of SARS-CoV-2 infection demonstrate poorer T cell immunity

Researchers assessed the association between obesity and T cell frequencies specific to the SARS-CoV-2 antigen.

1 Jul 2022

Key protein α-synuclein linked to inflammation and Parkinson's disease

Currently, there are no disease modifying therapies for Parkinson's disease that can change the progression of the disease. An international team of scientists led by faculty at the University of Colorado Anschutz Medical Campus is hoping to change that.

30 Jun 2022

Study shows long COVID remodeling of T cell dynamics is dependent on SARS-CoV-2 severity

A new study found that the post-COVID-19 functional remodeling of T cells occurs in two steps and confers different convalescent immune states, six months after SARS-CoV-2 infection.

30 Jun 2022

Casirivimab/imdevimab improve outcomes in early COVID-19

A new Viruses study determines the effect of casirivimab/imdevimab on IFN-1 and cytokines during SARS-CoV-2 infection.

29 Jun 2022

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Researchers assessed the impact of SARS-CoV-2 envelope protein on the bromodomain and extraterminal domain (BET) proteins.

29 Jun 2022

New technique offers higher-precision scRNA-seq data than current technologies

The advent of single-cell RNA sequencing (scRNA-seq) has revolutionized the fields of medicine and biology by providing the ability to study the inner workings of thousands of cells at one go.

28 Jun 2022

The potential of DNA-based SARS-CoV-2 vaccine candidates

Researchers evaluated the immunogenicity of DNA-based candidate vaccines against SARS-CoV-2 in mice.

28 Jun 2022

COVID-19 can cause metabolism problems by interfering with insulin signaling, study reveals

It has become abundantly clear that coronavirus disease 19 (COVID-19), despite being transmitted by breathing in the SARS-CoV-2 virus, can have harmful effects far beyond the lungs.

27 Jun 2022

Researchers report high rates of new TB infection among adolescents in Tanzania

Published today in PLOS ONE, "Serial T-SPOT.TB responses in Tanzanian adolescents: transient, persistent and irregular conversions" [https://doi.org/10.1371/journal.pone.0268685], investigators from the Geisel School of Medicine and Muhimibili University of Health and Allied Sciences report high rates of new tuberculosis (TB) infection among adolescents in Tanzania.

24 Jun 2022

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

In a recent study posted to the medRxiv* pre-print server, researchers in the United States characterized differential host immune responses in acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) to inform future development of novel biomarkers for both diseases.

23 Jun 2022

Interferon News and Research

Early treatment with interferons could mitigate severe COVID-19 in people with specific genetic factors

Antibody signatures strongly associated with SARS-CoV-2 immunopathology identified using a novel B cell epitope discovery method

The interaction between SARS-CoV-2 and influenza A during coinfection

Persistence of SARS-CoV-2 in tissues leads to long COVID

Activation of the STING pathway could help make glioblastoma multiforme more susceptible to immunotherapy

After 3 doses of COVID vaccine, most cancer patients retain detectable humoral immunity

Human milk immune activity may both lower and increase infants’ infectious disease risk

What role does human microbiota play in COVID-19 severity?

Vitamin D protects against H1N1 and SARS-CoV-2 infection in mice

Brain immune response to SARS-CoV-2 infection

Study evaluates if adults with obesity and a history of SARS-CoV-2 infection demonstrate poorer T cell immunity

Key protein α-synuclein linked to inflammation and Parkinson's disease

Study shows long COVID remodeling of T cell dynamics is dependent on SARS-CoV-2 severity

Casirivimab/imdevimab improve outcomes in early COVID-19

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

New technique offers higher-precision scRNA-seq data than current technologies

The potential of DNA-based SARS-CoV-2 vaccine candidates

COVID-19 can cause metabolism problems by interfering with insulin signaling, study reveals

Researchers report high rates of new TB infection among adolescents in Tanzania

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

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