Mouse Model News and Research

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Why hypoglycemia-induced glucagon secretion becomes impaired in diabetes

Findings indicate that excessive somatostatin inhibits glucagon secretion in type 1 diabetes, offering a novel target for hypoglycemia management strategies.

27 Sep 2024

New drug MED6-189 shows promise against drug-resistant malaria

In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite.

26 Sep 2024

Perceived stress can directly trigger psoriasis relapse

Innovative research has provided compelling evidence that perceived stress can directly trigger the relapse of psoriatic skin lesions. The study, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, is the first to scientifically validate this connection in vivo.

26 Sep 2024

Barcoding technology reveals secrets of cancer metastasis

Metastatic cancer can be a devastating diagnosis. The cancer is spreading. It may travel to multiple organs in the body. This could mean more pain and ultimately, death.

26 Sep 2024

Multi-omics analysis reveals mechanism of action for ruthenium-based anti-cancer agent

This study is led by Prof. Cai-Ping Tan, Prof. Zong-Wan Mao (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University) and Prof. Zheng-Qiu Li (School of Pharmacy, MOE Key Laboratory of Tumor Molecular Biology, Jinan University).

26 Sep 2024

Drug-free nasal spray demonstrates effectiveness in blocking viral and bacterial infections

Researchers from the Brigham detail how the spray they created may offer broad-spectrum protection from respiratory infections by COVID-19, influenza, everyday cold viruses, and pneumonia-causing bacteria

25 Sep 2024

Study uncovers decision-making impairments linked to Parkinson's drug

Parkinson's disease (PD), also known simply as Parkinson's, is a disorder of the nervous system that affects millions of people worldwide.

24 Sep 2024

New CRISPR model offers deeper insight into prostate cancer metastasis

A new preclinical model using CRISPR, an advanced technology that allows scientists to cut and edit genes, has given Weill Cornell Medicine researchers and their colleagues a deeper insight into how prostate cancer spreads or metastasizes.

23 Sep 2024

Dietary antigens reduce small intestine cancer by boosting immune T-cells

Study shows that dietary antigens can suppress small intestine carcinogenesis by activating T-cells through Peyer's patches. Adding bovine serum albumin (BSA) or ovalbumin (OVA) to antigen-free diets restored immune function and reduced tumor growth in mice.

22 Sep 2024

Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

Mount Sinai researchers uncover genetic basis of fibromuscular dysplasia

Mount Sinai researchers have identified a key driver of a blood vessel disorder known as fibromuscular dysplasia (FMD) which affects up to five percent of the adult population and can lead to high blood pressure, heart attack, or stroke.

14 Sep 2024

Scientists develop selective therapy for tau tangles

Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer's disease, and improve symptoms of neurodegeneration in mice.

14 Sep 2024

Salt can boost antitumor responses of T cells

Elevated sodium levels in tumors boost T-cell metabolic fitness and cytotoxicity, revealing potential avenues for improving cancer therapies.

13 Sep 2024

Researchers uncover why typically normal protein drives prostate cancer

NSD-2 is crucial for AR activity in prostate cancer, promoting tumor growth and offering a potential therapeutic target for advanced prostate cancer treatment.

12 Sep 2024

Pyroptosis found to promote wound healing and tissue repair

A study by the team of Prof. Kodi Ravichandran (VIB-UGent Center for Inflammation Research) and colleagues found that pyroptosis, a form of programmed cell death traditionally thought to be purely inflammatory, also plays a crucial role in promoting healing and tissue repair.

11 Sep 2024

Natural probiotic present in gut shortly after birth

Findings on neonatal gut microbiota reveal key Bifidobacteria species driving microbiome assembly and their potential in developing personalized probiotics.

10 Sep 2024

Researchers uncover mechanism fueling prostate cancer

Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer.

9 Sep 2024

Study reveals key signaling pathways driving lung cancer metastasis

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS signaling pathways work together to spur the spread of cancer in lung adenocarcinoma, a leading cause of cancer deaths around the world.

6 Sep 2024

Arthritis medications could reverse COVID lung damage

Arthritis drugs already available for prescription have the potential to halt lingering lung problems that can last months or years after COVID-19 infections, new research from the University of Virginia School of Medicine and Cedars-Sinai suggests.

6 Sep 2024