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New, open-source database improves genomics research collaboration

Sharing datasets that reveal the function of genomic variants in health and disease has become easier, with the launch of a new, open-source database developed by Australian and North American researchers.

3 Nov 2019

Certain gut bacteria can increase the risk of bowel cancer, shows study

People who have a certain type of bacteria in their guts may be at greater risk of developing bowel cancer.

3 Nov 2019

Chemotherapy can cause drug-resistant mutations in pediatric ALL patients who relapse

Chemotherapy has helped make the most common childhood cancer one of the most curable, but researchers have evidence that the treatment may also prime some patients for relapse.

2 Nov 2019

UI scientists are developing new delivery tools for gene editing

News of advances in gene-editing technology raises the prospect of actually using this approach to treat disease in patients. But one of the hurdles that remains is how to deliver these tools to the right cells in the patients safely and efficiently.

31 Oct 2019

Scientists visualize complex cellular machine to yield new insights in cancer

Cellular machines that control chromosome structure, such as the RSC complex, are mutated in about one-fifth of all human cancers.

31 Oct 2019

Researchers identify new kidney cancer subtypes and clues to better diagnosis, treatment

In what is believed to be the most comprehensive molecular characterization to date of the most common - and often treatment-resistant - form of kidney cancer, researchers at Johns Hopkins' departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them.

From Johns Hopkins Medicine 31 Oct 2019

Study shows how Chlamydia bacteria enter human cells

Chlamydia are bacteria that can infect human and animal cells. Human health is particularly affected by Chlamydia pneumoniae (Cpn) and Chlamydia trachomatis.

31 Oct 2019

Novel method for aggressive breast cancer detection

A new study in rats published in the journal Cell Reports shows that the pattern of RNA molecules produced within certain immune cells called macrophages, found within breast cancers (tumor-associated macrophages, TAMs), can tell whether the tumor is cancerous or not and indicate the type of outcome. The same pattern is present in humans as in mice. This makes it directly useful in predicting the nature of a breast tumor and its outcome.

30 Oct 2019

Scientists receive $1.6 million grant to study impact of phthalate exposure on male fertility

A cross-disciplinary team of scientists, led by University of Massachusetts Amherst environmental epigeneticist Richard Pilsner, will use a three-year, $1.6 million grant from the National Institute of Environmental Health Sciences to expand research into the impact of phthalate exposure on male fertility.

30 Oct 2019

Improved Cas9 enzyme reduces chance of off-target CRISPR mutations

Genomics experts have discovered that when guide RNAs (gRNA) are designed properly, the risk of off-target mutations induced by the cas9 enzyme is very rare.

30 Oct 2019

New collaborative effort focuses on therapeutic research for CDKL5 Deficiency Disorder

CDKL5 Deficiency Disorder is a devastating neurodevelopmental disorder caused by mutations in the CDKL5 gene.

30 Oct 2019

Novel, cost-effective method successfully identifies aggressive tumors

Researchers have developed a novel, cost-effective genomic method that can identify highly heterogenous tumors that are typically aggressive in nature.

30 Oct 2019

TDP-43 study could speed up the diagnosis and treatment of ALS

A new study suggests that TDP-43 may be used as a biomarker in the diagnosis and treatment of amyotrophic lateral sclerosis (ALS).

30 Oct 2019

DNA sequences encode information in many different ways

DNA sequences encode information in many different ways. Codons specify the amino acids involved in making a protein.

30 Oct 2019

Botswana now the origin of humans

A group of scientists have reported their new theory that human life was first seen in northern Botswana, south of the Zambezi river in Africa, according to their article published in the journal Nature.

29 Oct 2019

Boozing leads to small brains or people with small brains drink more?

Research has shown that excessive alcohol use is associated with reduction in brain volume. Now a new study has shown that brain volume is associated genetically with a predisposition to excessive alcohol consumption.

29 Oct 2019

Polygenic scoring system shows promise to predict depression risk and resilience under stress

Depression doesn't come from one gene, one life event, or one personality trait. That's what makes it so hard to predict, prevent or treat effectively.

29 Oct 2019

Researchers develop new genomic analysis method for identifying Yersinia strains

The Yersinia genus covers a vast range of bacteria that are distinguished by criteria such as whether or not they are able to cause disease (their pathogenicity).

29 Oct 2019

Study uses whole-genome sequencing for early identification and containment of AMR pathogens

A study published today in PNAS examines the evolutionary and epidemiologic history of an epidemic strain of extensively drug-resistant tuberculosis (XDR-TB) - called LAM4/KZN- in KwaZulu-Natal, South Africa.

29 Oct 2019

Some types of proteins can stabilize damaged DNA

At the University of Copenhagen, researchers have discovered how some types of proteins stabilize damaged DNA and thereby preserve DNA function and integrity. This new finding also explains why people with inborn or acquired defects in certain proteins cannot keep their DNA stable and develop diseases such as cancer.

28 Oct 2019

Genome News and Research

New, open-source database improves genomics research collaboration

Certain gut bacteria can increase the risk of bowel cancer, shows study

Chemotherapy can cause drug-resistant mutations in pediatric ALL patients who relapse

UI scientists are developing new delivery tools for gene editing

Scientists visualize complex cellular machine to yield new insights in cancer

Researchers identify new kidney cancer subtypes and clues to better diagnosis, treatment

Study shows how Chlamydia bacteria enter human cells

Novel method for aggressive breast cancer detection

Scientists receive $1.6 million grant to study impact of phthalate exposure on male fertility

Improved Cas9 enzyme reduces chance of off-target CRISPR mutations

New collaborative effort focuses on therapeutic research for CDKL5 Deficiency Disorder

Novel, cost-effective method successfully identifies aggressive tumors

TDP-43 study could speed up the diagnosis and treatment of ALS

DNA sequences encode information in many different ways

Botswana now the origin of humans

Boozing leads to small brains or people with small brains drink more?

Polygenic scoring system shows promise to predict depression risk and resilience under stress

Researchers develop new genomic analysis method for identifying Yersinia strains

Study uses whole-genome sequencing for early identification and containment of AMR pathogens

Some types of proteins can stabilize damaged DNA

Genetics & Genomics - Second Edition eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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