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BMI should be assessed in management of COVID-19 patients

A new study published on the preprint server medRxiv* in June 2020 reports that obesity is a risk factor of composite poor outcome of COVID-19 disease. On the other hand, COVID-19 patients with 'composite poor outcome' have higher BMI. Therefore, BMI should be assessed in the management of COVID-19 patients, and special attention should be given to patients with obesity.

1 Jul 2020

SARS-CoV-2 circulating in Brazil back in November 2019

The finding, published on the preprint server medRxiv in June 2020, shows that it has been causing infection in Brazil long before the first case was reported in the Americas, North and South, in January 2020, and certainly before the first case in this Brazilian region.

1 Jul 2020

Silk useful as face mask and PPE in COVID-19

As many people are resorting to face coverings improvised from common fabrics, researchers from the University of Cincinnati looked to determine what fabrics were the most effective. The team examined the hydrophobicity of fabrics (silk, cotton, polyester), as measured by their resistance to the penetration of small and aerosolized water droplets, an important transmission avenue for the virus causing COVID-19.

30 Jun 2020

New polymeric heart valve could be a life-saver

Millions of persons around the world suffer from diseased and damaged heart valves. These patients require valve repair surgeries, and often when that is not possible, they need to take blood-thinners for life to prevent complications.

30 Jun 2020

Striking CryoEM image of SARS-CoV-2

A new study by researchers from the UK and Germany and published on the preprint server bioRxiv in June 2020 reports the results of a detailed study of the S protein on the intact virus, using cryoelectron microscopy (cryoEM) and tomography. This could help understand the conformation of the S protein on the virion and how it interacts with neutralizing antibodies.

30 Jun 2020

New approach holds incredible potential for developing new therapeutics

Nearly every drug that is, or has ever been, used was derived from nature -- harnessing compounds created by organisms over eons to fight diseases. But decades ago, biochemists postulated that it might be possible to design a new drug from scratch by linking up amino acids in precise ways.

30 Jun 2020

Study provides first estimates of healthy working life expectancy for adults aged 50

A new study has estimated that on average people in England from age 50 can expect to be healthy and in work for nine more years.

30 Jun 2020

Study links unexpected hospital stays to negative outcomes in head and neck cancer patients

Patients who were unexpectedly hospitalized for dehydration, fever or other ailments while undergoing radiation treatment for head and neck cancers were at a higher risk for less favorable outcomes, a new study from Roswell Park Comprehensive Cancer Center reports.

30 Jun 2020

Researchers develop technique for personalizing stomach cancer therapy

Researchers from the Moscow Institute of Physics and Technology and their colleagues have developed the first technique for personalizing stomach cancer therapy based on RNA sequencing of tumor cells. The study, supported by the Russian Science Foundation, was published in Cold Spring Harbor Molecular Case Studies.

30 Jun 2020

Study explores time trends in pregnancy-related outcomes among women with type 1 diabetes

Researchers from the Joslin Diabetes Center investigated time trends in pregnancy-related outcomes among women with type 1 diabetes between 2004 and 2017, and found that the percentage of mothers with excess weight gain during pregnancy as well as the use of insulin pumps and CGMs increased significantly, while the prevalence of nephropathy fell dramatically to zero.

30 Jun 2020

Research shows how a protein's small change leads to big trouble for cells

In molecular biology, chaperones are a class of proteins that help regulate how other proteins fold. Folding is an important step in the manufacturing process for proteins. When they don't fold the way they're supposed to, it can lead to the development of diseases such as cancer.

30 Jun 2020

New study aims to identify how to better protect disabled children

How effective are we at safeguarding disabled children? An important new study which seeks to understand how to can better protect disabled children and young people from abuse starts this week.

30 Jun 2020

'Mini-brains' can be infected by SARS-CoV-2 virus

A multidisciplinary team from two Johns Hopkins University institutions, including neurotoxicologists and virologists from the Bloomberg School of Public Health and infectious disease specialists from the school of medicine, has found that organoids (tiny tissue cultures made from human cells that simulate whole organs) known as "mini-brains" can be infected by the SARS-CoV-2 virus that causes COVID-19.

30 Jun 2020

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that IQGAP1 is a signaling scaffold implicated in TNBC, but its mechanism is unknown.

30 Jun 2020

Potential new biomarker could improve COVID-19 diagnosis

Researchers at Montpellier University Hospital have discovered that an interferon-inducible receptor expressed on monocytes could be a useful biomarker for the rapid triaging of patients suspected to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

30 Jun 2020

In-home portable air cleaners reduce particulate exposure for cardiac patients

Using an in-home portable air cleaner (PAC) can significantly reduce exposure to fine-particle air pollutants - a major risk factor for cardiovascular events in people with pre-existing heart disease, reports a pilot study in the July issue of Journal of Cardiopulmonary Rehabilitation and Prevention.

30 Jun 2020

New study will help primary care nurses better care for dementia patients

McLean Hospital's Brent P. Forester, MD, MSc, is heading a new study of a training model to help primary care nurses better care for patients with dementia.

30 Jun 2020

Alternative antibiotics for unverified penicillin allergies likely unnecessary

Hospitalized patients who report an allergy to penicillin are often prescribed alternative antibiotics for infection that can be harmful, even though diagnostic testing or evaluations would show that the vast majority of these reported allergies could be disproven, according to researchers from Massachusetts General Hospital.

30 Jun 2020

A semi-empirical model to reproduce the brain states from wakefulness to deep sleep

The human brain is a complex system comprising 1010 non-linear units (neurons) that interact in 1015 sites (synapses).

30 Jun 2020

Scientists discover mechanism involving key protein that predicts cancer progression and relapse

Cancer cases have been rising over the years and according to the statistics, the number of people living with cancer will continue to increase.

30 Jun 2020

Research News and Research

BMI should be assessed in management of COVID-19 patients

SARS-CoV-2 circulating in Brazil back in November 2019

Silk useful as face mask and PPE in COVID-19

New polymeric heart valve could be a life-saver

Striking CryoEM image of SARS-CoV-2

New approach holds incredible potential for developing new therapeutics

Study provides first estimates of healthy working life expectancy for adults aged 50

Study links unexpected hospital stays to negative outcomes in head and neck cancer patients

Researchers develop technique for personalizing stomach cancer therapy

Study explores time trends in pregnancy-related outcomes among women with type 1 diabetes

Research shows how a protein's small change leads to big trouble for cells

New study aims to identify how to better protect disabled children

'Mini-brains' can be infected by SARS-CoV-2 virus

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

Potential new biomarker could improve COVID-19 diagnosis

In-home portable air cleaners reduce particulate exposure for cardiac patients

New study will help primary care nurses better care for dementia patients

Alternative antibiotics for unverified penicillin allergies likely unnecessary

A semi-empirical model to reproduce the brain states from wakefulness to deep sleep

Scientists discover mechanism involving key protein that predicts cancer progression and relapse

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