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Researchers find new role for SHARPIN protein in melanoma growth

Researchers at Sanford Burnham Prebys Medical Discovery and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex, regulating NFκB and other inflammatory molecules, SHARPIN modulates PRMT5, an epigenetic master switch that controls several proteins linked to melanoma. The research was published in The Journal of Clinical Investigation.

12 Dec 2017

Genentech researchers uncover epigenetic regulator of pancreatic cancer cells

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells' chromatin.

11 Dec 2017

Generic versions of Viagra coming this week

Drug manufacturer Pfizer is coming up with a cheaper and generic version of their erectile dysfunction pill Viagra this week.

10 Dec 2017

Simple molecular test may help predict presence of high-grade pancreatic cancers

A report in The Journal of Molecular Diagnostics, describes a new simple molecular test to detect chromosomal abnormalities -- biomarkers known as telomere fusions--in pancreatic tumor specimens and pancreatic cyst fluids.

8 Dec 2017

PARP inhibitor can be new treatment option for patients with metastatic breast cancer, BRCA mutations

In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

8 Dec 2017

Common fungus has significant impact on mosquitoes' ability to transmit dengue virus

A species of fungus that lives in the gut of some Aedes aegypti mosquitoes increases the ability of dengue virus to survive in the insects, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.

7 Dec 2017

Study paves way for new therapeutic strategies to impede growth of virus-induced cancers

Researchers at the Cancer Science Institute of Singapore at the National University of Singapore have identified a novel molecular pathway by which a tumor suppressor, TIP60, inhibits the growth of cancer cells.

7 Dec 2017

Study shows how interplay between two key enzymes promotes brain tumor growth

Study results revealed previously unknown interplay between two key enzymes and a novel understanding of how brain cancer tumors form and spread, according to researchers at The University of Texas MD Anderson Cancer Center.

6 Dec 2017

High ADAR1 enzyme levels correlate with reduced survival rates in multiple myeloma

Multiple myeloma is the second most common blood cancer in the United States. Thirty to 50 percent of multiple myeloma patients have extra copies of the gene that encodes the enzyme ADAR1.

6 Dec 2017

Researcher discovers enzyme pathway involved in ALS pathogenesis

It is estimated that between 14,000 and 15,000 Americans have amyotrophic lateral sclerosis (ALS), according to the National Institutes of Health. Symptoms of ALS, also known as Lou Gehrig's disease, may be subtle at first but develop into more obvious muscle weakness and paralysis.

5 Dec 2017

Research reveals exposure to harmful pesticide levels among residents of major Pakistan city

Residents and workers in a major Pakistan city are exposed to harmful levels of pesticides, new research reveals.

1 Dec 2017

Researchers discover ‘brake’ that interferes with HIV's development into infectious agent

Viewed with a microscope, the virus faintly resembles a pineapple--the universal symbol of welcome. But HIV, the virus that causes AIDS, is anything but that. It has claimed the lives of more than 35 million people so far.

1 Dec 2017

Drug that stimulates neuron pruning promotes goal-directed behavior in mice

A drug that stimulates neuron pruning can nudge mice away from habit-driven behaviors when combined with retraining, neuroscientists have found.

30 Nov 2017

Researchers unlock genetic processes underlying cancer

For many, breast cancer is more than just a disease – it's personal. One in eight women will be diagnosed with breast cancer at some point in their lives. But through new discoveries at the genetic level, the personal nature of cancer will eventually be what helps to beat it.

29 Nov 2017

UT Southwestern researchers take early step toward personalized care for breast cancer

UT Southwestern Medical Center researchers have developed a method to map protein changes that occur in different subtypes of breast cancer cells in response to DNA damage from a new class of chemotherapy drugs.

29 Nov 2017

Researchers identify key mechanism by which obesity causes type 2 diabetes

UT Southwestern researchers have identified a major mechanism by which obesity causes type 2 diabetes, which is a common complication of being overweight that afflicts more than 30 million Americans and over 400 million people worldwide.

28 Nov 2017

New cancer drug begins clinical trial in human patients with rare brain tumor

A drug that spurs cancer cells to self-destruct has been cleared for use in a clinical trial of patients with anaplastic astrocytoma, a rare malignant brain tumor, and glioblastoma multiforme, an aggressive late-stage cancer of the brain.

28 Nov 2017

Researchers discover critical trigger for leading form of vision loss

In a major step forward in the battle against macular degeneration, the leading cause of vision loss among the elderly, researchers at the University of Virginia School of Medicine have discovered a critical trigger for the damaging inflammation that ultimately robs millions of their sight.

27 Nov 2017

Desert soil analysis reveals treasure trove of microorganisms with potential to fight disease

Soils from one of the highest, driest places on earth harbor microorganisms with the potential to treat HIV and tackle the world's antibiotic time bomb, research from Newcastle University, UK, has revealed.

27 Nov 2017

Study finds unexpected new drug target for acute myeloid leukemia

A study has found an unexpected new drug target for acute myeloid leukemia (AML) that could open new avenues to develop effective treatments against this potentially lethal disease.

27 Nov 2017

Enzyme News and Research

Researchers find new role for SHARPIN protein in melanoma growth

Genentech researchers uncover epigenetic regulator of pancreatic cancer cells

Generic versions of Viagra coming this week

Simple molecular test may help predict presence of high-grade pancreatic cancers

PARP inhibitor can be new treatment option for patients with metastatic breast cancer, BRCA mutations

Common fungus has significant impact on mosquitoes' ability to transmit dengue virus

Study paves way for new therapeutic strategies to impede growth of virus-induced cancers

Study shows how interplay between two key enzymes promotes brain tumor growth

High ADAR1 enzyme levels correlate with reduced survival rates in multiple myeloma

Researcher discovers enzyme pathway involved in ALS pathogenesis

Research reveals exposure to harmful pesticide levels among residents of major Pakistan city

Researchers discover ‘brake’ that interferes with HIV's development into infectious agent

Drug that stimulates neuron pruning promotes goal-directed behavior in mice

Researchers unlock genetic processes underlying cancer

UT Southwestern researchers take early step toward personalized care for breast cancer

Researchers identify key mechanism by which obesity causes type 2 diabetes

New cancer drug begins clinical trial in human patients with rare brain tumor

Researchers discover critical trigger for leading form of vision loss

Desert soil analysis reveals treasure trove of microorganisms with potential to fight disease

Study finds unexpected new drug target for acute myeloid leukemia

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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