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Researchers study typhoid genomes of travelers from different parts of the world

Salmonella enterica serovar Typhi causes more than 20 million cases of typhoid fever each year, and disproportionately infects children in low and middle income countries.

From PLOS ONE 17 Sep 2019

Mutated ciliary genes tied to heart valve birth defect

The heart pumps blood throughout the body to provide the needed oxygen and nutrients. In the heart, blood flows to get oxygen from the lungs to deliver to the cells. Some of the most important structures in the heart are the valves, because they prevent the backflow of blood, avoiding the mixture of oxygenated blood with the ones that still need to be oxygenated.

17 Sep 2019

New method developed to address failures in promising anti-cancer drug

Biomedical engineers at Duke University have developed a method to address failures in a promising anti-cancer drug, bringing together tools from genome engineering, protein engineering and biomaterials science to improve the efficacy, accuracy and longevity of certain cancer therapies.

17 Sep 2019

Cure for Rett Syndrome a step closer as scientists successfully reactivate 'back-up’ genes

A team headed by Vincent Pasque at his Lab at KU Leuven alongside researchers from the Jean-Christophe Marine lab and the Edith Heard lab have made a significant step towards developing a treatment for Rett syndrome and other X chromosome linked disorders.

17 Sep 2019

Stopping cold viruses dead by blocking replication

The common cold virus (and its more deadly cousins, the viruses that cause polio and acute flaccid myelitis) may just have met its nemesis. In a recent study published in the journal Nature Microbiology on September 16, 2019, scientists reported a potentially successful new approach to stop cold viruses from replicating inside human cells – by blocking the formation of a protein that is vital to this process.

17 Sep 2019

Stanford-UCSF researchers report new cure for common cold in human cells and mice

Temporarily disabling a single protein inside our cells might be able to protect us from the common cold and other viral diseases, according to a study led by researchers at Stanford University and University of California-San Francisco.

16 Sep 2019

Biologists observe how microtubules branch in new directions in animal cells

Cell biologist Thomas Maresca and senior research fellow Vikash Verma at the University of Massachusetts Amherst say they have, for the first time, directly observed and recorded in animal cells a pathway called branching microtubule nucleation, a mechanism in cell division that had been imaged in cellular extracts and plant cells but not directly observed in animal cells.

16 Sep 2019

Scientists design new model for predicting what might make an effective cancer vaccine

Scientists at the University of North Carolina Lineberger Comprehensive Cancer Center have designed and validated a model for predicting what might make an effective cancer vaccine against a patient's tumor.

13 Sep 2019

Discovery opens up new opportunities to understand the genetics of cancer

University of Delaware molecular biologist Mona Batish and collaborators at Harvard Medical School and University of California, Los Angeles, have identified a new circular ribonucleic acid (RNA) that increases tumor activity in soft tissue and connective tissue tumors.

13 Sep 2019

Humans have very individualized inflammatory responses to high-fat meal

People have very individualized inflammatory responses to eating a high-fat meal.

12 Sep 2019

New liquid biopsy test may be more predictive of patient's immunotherapy response

A new liquid biopsy test could detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating that it could help determine which patients are likely to respond to immune checkpoint inhibitors.

11 Sep 2019

A gene that acts as master regulator of schizophrenia identified

Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of schizophrenia during early human brain development.

11 Sep 2019

Gene coding error likely responsible for rare form of inherited 'short telomere' disease

By combing through the entire genetic sequences of a person with a lung scarring disease and 13 of the person’s relatives, Johns Hopkins Medicine researchers say they have found a coding error in a single gene that is likely responsible for a rare form of the disease and the abnormally short protective DNA caps on chromosomes long associated with it.

From Johns Hopkins Medicine 11 Sep 2019

Scientists discover new strain of group A streptococcus bacteria in England and Wales

A team of scientists led by Imperial College London have discovered a new strain of group A streptococcus bacteria.

11 Sep 2019

Genetic engineering could open possibilities for patients with Parkinson’s disease

People with Parkinson’s disease experience loss of dopamine-producing brain cells, leading to tremors, rigidity, bradykinesia, and postural instability, the primary symptoms of the disease.

11 Sep 2019

Long-term antibiotic use in preemies promotes drug-resistant gut bacteria

Very preterm infants are often sick and require antibiotic treatment to save their lives. However, when this form of therapy lasts for 20 months or more, it may affect the gut microbiome over the long-term in addition to its acute effects.

10 Sep 2019

Nanocapsules packed with gene-editing tools could be promising platform for many gene therapies

New tools for editing genetic code offer hope for new treatments for inherited diseases, some cancers, and even stubborn viral infections. But the typical method for delivering gene therapies to specific tissues in the body can be complicated and may cause troubling side effects.

10 Sep 2019

Liquid biopsies provide complete picture of genetic alterations linked to cancer drug resistance

Many patients see their tumors shrink in response to a drug, only to have them come back with a vengeance as they evolve to fend off the treatment. Oncologists want to be able to quickly detect cancer drug resistance as it emerges in their patients and identify another drug the tumors will still respond to.

10 Sep 2019

Salk researchers develop method to reveal epigenetic features of brain cells

The brain's prefrontal cortex, which gives us our ability to solve problems and plan ahead, contains billions of cells. But understanding the large diversity of cell types in this critical region, each with unique genetic and molecular properties, has been challenging.

10 Sep 2019

Lefthandedness genes change the way the brain develops

A new study has discovered four genes related to left-handedness, and the associated differences in the way the brain is organized. About a tenth of people are left-handed, making this a not uncommon trait. However, the new findings point to greater verbal fluency with this alternate version of the brain, compared to right-handedness.

6 Sep 2019

Genome News and Research

Researchers study typhoid genomes of travelers from different parts of the world

Mutated ciliary genes tied to heart valve birth defect

New method developed to address failures in promising anti-cancer drug

Cure for Rett Syndrome a step closer as scientists successfully reactivate 'back-up’ genes

Stopping cold viruses dead by blocking replication

Stanford-UCSF researchers report new cure for common cold in human cells and mice

Biologists observe how microtubules branch in new directions in animal cells

Scientists design new model for predicting what might make an effective cancer vaccine

Discovery opens up new opportunities to understand the genetics of cancer

Humans have very individualized inflammatory responses to high-fat meal

New liquid biopsy test may be more predictive of patient's immunotherapy response

A gene that acts as master regulator of schizophrenia identified

Gene coding error likely responsible for rare form of inherited 'short telomere' disease

Scientists discover new strain of group A streptococcus bacteria in England and Wales

Genetic engineering could open possibilities for patients with Parkinson’s disease

Long-term antibiotic use in preemies promotes drug-resistant gut bacteria

Nanocapsules packed with gene-editing tools could be promising platform for many gene therapies

Liquid biopsies provide complete picture of genetic alterations linked to cancer drug resistance

Salk researchers develop method to reveal epigenetic features of brain cells

Lefthandedness genes change the way the brain develops

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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