Clinical Trial News and Research

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Dietary supplement improves neuronal function of a patient with atypical Rett syndrome

A multicentric translational research study carried out by groups of the Bellvitge Biomedical Research Institute, Sant Joan de Déu Hospital, the University of Barcelona, Hospital Clínic, the University of Vic, Sant Pau i la Santa Creu Hospital, the Rare Diseases Networking Biomedical Research Centre and the Commissariat à l'Énergie Atomique, has demonstrated the potential of the amino acid L-serine - administered as a dietary supplement - to improve the neuronal function of a patient with a mutation of glutamate receptors associated with atypical Rett syndrome with severe encephalopathy.

19 Jun 2019

Scientists pinpoint cause of fatal respiratory disorder that turns babies' lips and skin blue

Scientists used a gene editing method called CRISPR/Cas9 to generate mice that faithfully mimic a fatal respiratory disorder in newborn infants that turns their lips and skin blue. The new laboratory model allowed researchers to pinpoint the ailment's cause and develop a potential and desperately needed nanoparticle-based treatment.

19 Jun 2019

Three signs of real progress against sickle cell disease

A decade ago, the United Nations declared June 19 to be World Sickle Cell Awareness Day- and for good reason.

19 Jun 2019

Researchers identify genes linked with survival in children with biliary atresia

Scientists at Cincinnati Children's Hospital Medical Center have identified an expression pattern of 14 genes at the time of diagnosis that predicts two year, transplant-free survival in children with biliary atresia – the most common diagnosis leading to liver transplants in children.

19 Jun 2019

National trial to settle debate on managing airways in emergencies

The University of Pittsburgh School of Medicine and UPMC will lead nearly two dozen emergency medical service agencies across the country in a Department of Defense-funded clinical trial aimed at improving survival among people who have difficulty breathing after a trauma.

18 Jun 2019

Duke researchers identify enzyme involved in regulating growth, spread of breast cancers

Immunotherapies have transformed cancer care, but their successes have been limited for reasons that are both complex and perplexing.

18 Jun 2019

Researchers investigate why many cancer clinical trials fail to enroll enough patients

The increasing sophistication of cancer treatments threatens to outpace the ability of health care providers to enroll patients in clinical trials to test those therapies. That's a key finding by researchers in UT Southwestern's new Department of Population and Data Sciences.

18 Jun 2019

Ochsner Hospital for Children joins national consortium to provide solutions for hypoplastic left heart syndrome

Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome and Ochsner Hospital for Children are collaborating within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.

17 Jun 2019

Topical cream found to be effective in reversing the effects of vitiligo

A nationwide phase II clinical trial, coordinated out of Tufts Medical Center in Boston, has found that a topical cream was extremely effective in reversing the effects of vitiligo, a relatively common autoimmune disease that causes loss of skin pigmentation.

17 Jun 2019

Harvard chemists achieve landmark in drug discovery with synthesis of potent anti-cancer agent

It's a feat three decades in the making: Harvard University chemists have achieved what a new paper calls a "landmark in drug discovery" with the total synthesis of halichondrin.

17 Jun 2019

Researchers find characteristics related to better outcomes in HPV-linked oropharyngeal cancer

Using a new blood test that's in development, University of North Carolina Lineberger Comprehensive Cancer Center researchers identified characteristics that could be used to personalize treatment for patients with a type of head and neck cancer linked to HPV infection.

16 Jun 2019

New radiation technique shows promise for treating patients with essential tremor

Tyrus Agee thought his promising new career was doomed. He had only one year left to finish his Doctor of Optometry degree at the University of Alabama at Birmingham School of Optometry.

16 Jun 2019

Common traits keep many patients with knee cartilage issues from participating in clinical trials

Some of the most common traits among patients with cartilage issues in the knee are excluding them from participating in clinical trials because the trial outcomes might not yield the optimum results for new methods of cartilage regeneration, according to a Penn Medicine study published in Regenerative Medicine.

16 Jun 2019

Long-acting contraceptives do not increase risk of HIV, concludes new study

One of the largest and most robust studies on HIV infection rates has concluded that long-acting contraceptives do not increase the risk of contracting HIV.

14 Jun 2019

Research suggests new way to improve the efficacy of arthritis drug

Attaching a removable lock to an arthritis drug can make it safer and more effective, according to a new study publishing June 13 in the open-access journal PLOS Biology led by Wen-Wei Lin of Kaohsiung Medical University, Taiwan.

From PLOS ONE 14 Jun 2019

New implant technology safely minimizes injections for people with macular degeneration

In a clinical trial of 220 people with “wet” age-related macular degeneration, Johns Hopkins Medicine researchers, collaborators from many sites across the country, and Genentech in South San Francisco have added to evidence that using a new implant technology that continuously delivers medication into the eyes is safe and effective in helping maintain vision and reduces the need for injections in the eyes.

From Johns Hopkins Medicine 14 Jun 2019

Roswell Park physician leads effort to compile new multiple myeloma imaging guidelines

Just as newer drugs have significantly improved outcomes for patients with multiple myeloma in the past decade, newer imaging techniques are upgrading detection of the disease, leading to earlier treatment.

14 Jun 2019

Cooking vegetables with extra virgin olive oil favors absorption, release of bioactive compounds

Cooking vegetables in the sofrito with extra virgin olive oil favors the absorption and release of bioactive compounds of its traditional ingredients, according to the study conducted by a research team of the Faculty of Pharmacy and Food Sciences at the University of Barcelona, from the Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre and the Diabetes and Associated Metabolic Diseases Networking Biomedical Research, led by the tenure lecturer Rosa M. Lamuela.

14 Jun 2019

UAMS-developed noninvasive device detects melanoma in earliest stages

A University of Arkansas for Medical Sciences research team led by Vladimir Zharov, Ph.D., D.Sc., has demonstrated the ability to detect and kill circulating tumor cells in the blood using a noninvasive device called Cytophone that integrates a laser, ultrasound and phone technologies.

13 Jun 2019

Vitamin D and estrogen can prevent heart disease, stroke, and diabetes in women

Vitamin D and estrogen have already shown well-documented results in improving bone health in women.

12 Jun 2019

Clinical Trial News and Research

Dietary supplement improves neuronal function of a patient with atypical Rett syndrome

Scientists pinpoint cause of fatal respiratory disorder that turns babies' lips and skin blue

Three signs of real progress against sickle cell disease

Researchers identify genes linked with survival in children with biliary atresia

National trial to settle debate on managing airways in emergencies

Duke researchers identify enzyme involved in regulating growth, spread of breast cancers

Researchers investigate why many cancer clinical trials fail to enroll enough patients

Ochsner Hospital for Children joins national consortium to provide solutions for hypoplastic left heart syndrome

Topical cream found to be effective in reversing the effects of vitiligo

Harvard chemists achieve landmark in drug discovery with synthesis of potent anti-cancer agent

Researchers find characteristics related to better outcomes in HPV-linked oropharyngeal cancer

New radiation technique shows promise for treating patients with essential tremor

Common traits keep many patients with knee cartilage issues from participating in clinical trials

Long-acting contraceptives do not increase risk of HIV, concludes new study

Research suggests new way to improve the efficacy of arthritis drug

New implant technology safely minimizes injections for people with macular degeneration

Roswell Park physician leads effort to compile new multiple myeloma imaging guidelines

Cooking vegetables with extra virgin olive oil favors absorption, release of bioactive compounds

UAMS-developed noninvasive device detects melanoma in earliest stages

Vitamin D and estrogen can prevent heart disease, stroke, and diabetes in women

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