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Treating cystic fibrosis: an interview with Simon Bedson, Senior Vice President and International General Manager at Vertex

Cystic fibrosis is a rare, life-shortening genetic disease for which there is no cure. It affects more than 75,000 people worldwide. In CF, thick, sticky mucus blocks the passages in many organs, leading to a variety of symptoms. In particular, mucus builds up and clogs airways in the lungs making it easier for bacteria to grow.

5 Mar 2014

Agenus reports net loss attributable to common stockholders of $5.8 million for Q4 2013

Agenus Inc., a biopharmaceutical company developing a portfolio of immuno-oncology candidates, including checkpoint modulators (CPMs), heat shock protein vaccines and adjuvants, today announced its financial results and business highlights for the fourth quarter and year ended December 31, 2013.

5 Mar 2014

Kamada initiates Phase 2/3 clinical trial of Glassia to treat pediatric patients with T1D

Kamada Ltd. (NASDAQ:KMDA) (TASE:KMDA), a plasma-derived protein therapeutics company focused on orphan indications, announces the initiation of a Phase 2/3 clinical trial of Glassia®, the Company's proprietary human Alpha-1 Antitrypsin (AAT), to treat newly diagnosed pediatric patients with type 1 diabetes (T1D).

5 Mar 2014

Researchers identify high levels of certain protein in brains of people suffering from essential tremor

A team of researchers from Universit- Laval and CHU de Qu-bec identified unusually high levels of a certain protein in the brains of people suffering from essential tremor (ET), a movement disorder that affects 4% of the adult population.

5 Mar 2014

Cell-cycle arrest biomarkers validated for acute kidney injury

Saeed A. Jortani, Ph.D., associate clinical professor in the University of Louisville's Department of Pathology and Laboratory Medicine, headed up one of three labs in the United States involved in determining two new markers for acute kidney injury (AKI). The research group's paper, "Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication," was posted online Feb. 25 by the American Journal of Respiratory and Critical Care Medicine.

5 Mar 2014

$Researchers develop silk-based surgical plates and screws to repair bone fractures$

Researchers develop silk-based surgical plates and screws to repair bone fractures

When a person suffers a broken bone, treatment calls for the surgeon to insert screws and plates to help bond the broken sections and enable the fracture to heal. These "fixation devices" are usually made of metal alloys.

5 Mar 2014

Researchers unravel function of proteins involved in cell metabolism

UCPs or uncoupling proteins are present in mitochondria, the powerhouse of each cell in the body. The functions of most of the five known UCPs remain mysterious (UCP2-UCP5), whereby only the distinct function for UCP1 has thus far been discovered.

5 Mar 2014

Eisai collaborates with Biogen Idec to develop and commercialize treatment options for AD

Eisai Co., Ltd. and Biogen Idec announced today that they have entered into a collaboration to develop and commercialize two of Eisai's clinical candidates for Alzheimer's disease (AD), E2609 and BAN2401.

5 Mar 2014

New probes help to quantify normally folded and misfolded conformations of protein in cells

Scientists at The Scripps Research Institute (TSRI) have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest in cells under different conditions.

5 Mar 2014

Mcl-1 protein enables NSCLC to survive radiation and drug treatments

Researchers at the Translational Genomics Research Institute have discovered a protein, Mcl-1, that helps enable one of the most common and deadly types of cancer to survive radiation and drug treatments.

5 Mar 2014

Eating high-protein diet in middle age is as deadly as smoking

That chicken wing you're eating could be as deadly as a cigarette. In a new study that tracked a large sample of adults for nearly two decades, researchers have found that eating a diet rich in animal proteins during middle age makes you four times more likely to die of cancer than someone with a low-protein diet - a mortality risk factor comparable to smoking.

5 Mar 2014

Stem cells from patients offer model, drug-discovery platform for early-onset form of Alzheimer's

Harvard stem cell scientists have successfully converted skins cells from patients with early-onset Alzheimer's into the types of neurons that are affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells. This may also make it possible to develop therapies far more quickly and accurately than before.

5 Mar 2014

Experimental drug nivolumab shrinks tumors in patients with advanced melanoma

An experimental drug aimed at restoring the immune system's ability to spot and attack cancer halted cancer progression or shrank tumors in patients with advanced melanoma, according to a multisite, early-phase clinical trial at Johns Hopkins Kimmel Cancer Center and 11 other institutions. All patients had experienced disease progression despite prior systemic therapies, and most had received two or more prior treatments.

4 Mar 2014

Bruker opens new preclinical imaging center of excellence for the Americas

Bruker (NASDAQ: BRKR) today announced the official opening of a new Preclinical Imaging Center of Excellence for the Americas in Billerica, Massachusetts. The facility offers advanced development, demonstration and support facilities for Bruker’s industry-leading portfolio of preclinical imaging instrumentation and multimodal platforms.

4 Mar 2014

Beckman Coulter Life Sciences announces agreement with Wyatt Technology Corporation

Beckman Coulter Life Sciences today announced an agreement with Wyatt Technology Corporation enabling collaboration on products, applications and technical development. The partnership brings together Wyatt’s expertise in protein characterization, light scattering and biophysics with Beckman Coulter’s expertise in particle counting, particle characterization and cell viability measurement.

4 Mar 2014

GTx provides clinical updates, reports financial results for fourth quarter and full year 2013

GTx, Inc. today provided a Company update and reported financial results for the fourth quarter and full year 2013.

4 Mar 2014

Procellera technology enhances cell migration in in-vitro laboratory testing

Procellera – the world's first wireless microcurrent generating dressing that produces electrical fields through its matrix of microcell batteries – was found to significantly enhance cell migration in in-vitro laboratory testing, according to groundbreaking research led by The Ohio State University Wexner Medical Center Professor Chandan K. Sen. Professor Sen is also the Director of the Comprehensive Wound Center at Ohio State.

4 Mar 2014

Drug that unleashes immune system can produce lasting remissions in patients with melanoma

A drug that unleashes the immune system to attack cancer can produce lasting remissions and hold the disease in check - for more than two years, in some cases - in many patients with advanced melanoma, according to a new study by researchers at Dana-Farber Cancer Institute, Johns Hopkins University, Yale University, and allied institutions.

4 Mar 2014

Blocking myoferlin gene can reduce breast cancer cell migration

New research suggests that a protein only recently linked to cancer has a significant effect on the risk that breast cancer will spread, and that lowering the protein's level in cell cultures and mice reduces chances for the disease to extend beyond the initial tumor.

4 Mar 2014

Researchers identify drug using yeast model that reduces levels of toxic protein in brains of AD patients

Using a yeast model of Alzheimer's disease (AD), Whitehead Institute researchers have identified a drug that reduces levels of the toxic protein fragment amyloid-β (Aβ) and prevents at least some of the cellular damage caused when Aβ accumulates in the brains of AD patients.

4 Mar 2014

G Protein News and Research

Treating cystic fibrosis: an interview with Simon Bedson, Senior Vice President and International General Manager at Vertex

Agenus reports net loss attributable to common stockholders of $5.8 million for Q4 2013

Kamada initiates Phase 2/3 clinical trial of Glassia to treat pediatric patients with T1D

Researchers identify high levels of certain protein in brains of people suffering from essential tremor

Cell-cycle arrest biomarkers validated for acute kidney injury

Researchers develop silk-based surgical plates and screws to repair bone fractures

Researchers unravel function of proteins involved in cell metabolism

Eisai collaborates with Biogen Idec to develop and commercialize treatment options for AD

New probes help to quantify normally folded and misfolded conformations of protein in cells

Mcl-1 protein enables NSCLC to survive radiation and drug treatments

Eating high-protein diet in middle age is as deadly as smoking

Stem cells from patients offer model, drug-discovery platform for early-onset form of Alzheimer's

Experimental drug nivolumab shrinks tumors in patients with advanced melanoma

Bruker opens new preclinical imaging center of excellence for the Americas

Beckman Coulter Life Sciences announces agreement with Wyatt Technology Corporation

GTx provides clinical updates, reports financial results for fourth quarter and full year 2013

Procellera technology enhances cell migration in in-vitro laboratory testing

Drug that unleashes immune system can produce lasting remissions in patients with melanoma

Blocking myoferlin gene can reduce breast cancer cell migration

Researchers identify drug using yeast model that reduces levels of toxic protein in brains of AD patients

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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