Therapeutics News and Research

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Targeting blood-clotting protein may help treat multiple sclerosis and other diseases

Picture a bare wire, without its regular plastic coating. It's exposed to the elements and risks being degraded. And, without insulation, it may not conduct electricity as well as a coated wire. Now, imagine this wire is inside your brain.

2 Nov 2017

SENIOR trial: Shorter DAPT combined with Synergy stent superior to BMS in elderly patients

Elderly patients undergoing PCI often receive bare-metal stents (BMS) instead of drug-eluting stents (DES) to shorten the duration of dual antiplatelet therapy (DAPT) and reduce bleeding risk. However, results from the SENIOR trial found that compared with BMS, shorter DAPT combined with the Synergy bioabsorbable polymer DES leads to less adverse events without increasing bleeding risk.

2 Nov 2017

Discovery of genetic markers could guide individualized treatments for advanced prostate cancer

Researchers at Mayo Clinic Center for Individualized Medicine have uncovered genetic clues to why tumors resist a specific therapy used for treating advanced prostate cancer.

2 Nov 2017

Pioneering heart device found to be safe and effective

A new study has found that a pioneering device to repair heart valves is safe and effective, and can reduce the invasiveness and side effects of conventional mitral valve surgery.

1 Nov 2017

Trial shows cost-effectiveness of TAVR compared to SAVR in intermediate risk patients with aortic stenosis

Analysis of the PARTNER 2A trial and the SAPIEN-3 Intermediate Risk registry found transcatheter aortic valve replacement (TAVR) to be highly cost-effective compared with surgical aortic valve replacement (SAVR) in intermediate surgical risk patients with aortic stenosis.

1 Nov 2017

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways.

1 Nov 2017

Repositive introduces first Global PDX Directory at AACR conference

The first Global PDX Directory for proprietary and open source PDX models is being introduced by Cambridge (UK) based benefit corporation, Repositive, at the American Association for Cancer Research’sInternational Conference, on Molecular Targets and Cancer Therapeutics, hosted in conjunction with the European Organisation for Research and Treatment of Cancer and the National Cancer Institute, in Philadelphia, USA, 26-30 October 2017.

1 Nov 2017

Vedantra and Neon Therapeutics extend research alliance to develop impactful cancer therapies

Vedantra Pharmaceuticals, Inc., an immunotherapy company focused on developing products to treat cancer and infectious disease, and Neon Therapeutics, an immuno-oncology company developing neoantigen-based therapeutic vaccines and T-cell therapies to treat cancer, announced today that the companies have extended their non-exclusive research alliance.

31 Oct 2017

Gene therapy prevents age-related learning and memory problems in mice

Researchers from the Institute of Neurosciences at the Universitat Autònoma de Barcelona and the Vall d'Hebron Research Institute are the first to demonstrate that regulation of the brain's Klotho gene using gene therapy protects against age-related learning and memory problems in mice.

31 Oct 2017

SU2C and its collaborators announce four teams to intercept cancer at earliest stages

Stand Up To Cancer, joined by the Lustgarten Foundation for Pancreatic Cancer Research, LUNGevity, and the American Lung Association, announced today four teams of top researchers who will carry out an attack on cancers of the lung and pancreas using a radical new approach of “interception” of cancers at very early stages, when they can be more successfully treated.

31 Oct 2017

New device holds potential for early detection of cavities

Imagine if dentists could find clear signs of tooth decay long before dental lesions turn into cavities and without using X-rays. A new device cleared for commercialization this month by the Food and Drug Administration (FDA) is a potential tool for dentists to do just that.

30 Oct 2017

Biogen and Ionis awarded 2017 Prix Galien USA Award for SPINRAZA

Biogen and Ionis have been awarded the prestigious 2017 Prix Galien USA Award for Best Biotechnology Product for SPINRAZA (nusinersen). The Prix Galien USA Award recognizes extraordinary achievement in scientific innovation that improves the state of human health. The award was presented at a ceremony in New York City on October 26, 2017.

30 Oct 2017

Montmorency tart cherry juice found to help extend sleep time among adults 50 years and older

Montmorency tart cherry juice was found to help extend sleep time by 84 minutes among eight study participants, ages 50 and older who suffer from insomnia, according to a new pilot study published in American Journal of Therapeutics.

28 Oct 2017

ACIST Medical Systems announces debut of next generation FFR solution

ACIST Medical Systems, Inc., a Bracco Group Company, today announced the global launch of its ACIST RXi Mini System, the next generation system of its RXi Rapid Exchange FFR System. The RXi Mini System will debut at the 29th Transcatheter Cardiovascular Therapeutics scientific symposium in Denver, Colorado.

28 Oct 2017

UC San Diego Health scientists help create ‘dream team’ to prevent pancreatic cancer

Scientists and physicians at Moores Cancer Center at UC San Diego Health, in partnership with colleagues at MD Anderson Cancer Center in Texas, Johns Hopkins University in Maryland and elsewhere, have been awarded a $7 million grant over four years by Stand Up to Cancer to create a "dream team" to develop new ways to prevent pancreatic cancer -- one of the nation's deadliest malignancies.

28 Oct 2017

New findings offer promising druggable target to root out metastatic pancreatic cancer

Cancer of the pancreas is a deadly disease, with a median survival time of less than six months. Only one in 20 people with pancreatic cancer survives five years past the diagnosis. The reason is the cancer's insidiousness; tumor cells hide deep inside the body, betraying no symptoms until late in the disease, when the cancer has almost invariably spread to other organs.

28 Oct 2017

Clinical trial shows promising results for treatment of patients with recurrent high-grade glioma

New data from a Phase I clinical trial led by Clark Chen, M.D., Ph.D., Lyle French Chair in Neurosurgery and Head of the University of Minnesota Medical School Department of Neurosurgery shows more than a quarter of patients with recurrent high-grade glioma, a form of brain cancer, were alive more than three years after treatment.

28 Oct 2017

Novel consortium aims to create new paradigm of cancer drug discovery

Scientists from two U.S. national laboratories, industry and academia today launched an unprecedented effort to transform the way cancer drugs are discovered by creating an open and sharable platform that integrates high-performance computing, shared biological data from public and industry sources and emerging biotechnologies to dramatically accelerate the discovery of effective cancer therapies.

27 Oct 2017

New concise guide to pharmacology offers key information on major drug targets

The Concise Guide to PHARMACOLOGY 2017/18 is now available in the British Journal of Pharmacology. Published by Wiley on behalf of the British Pharmacological Society, the 440 page guide includes overviews of key properties for close to 1,700 human drug targets, identifies 3,500 ligands including more than 2,400 synthetic organic molecules and over 50 antibodies.

27 Oct 2017

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Several patients with recurring glioblastoma, a deadly brain cancer, survived for more than a year in a clinical trial believed to be the first to use comprehensive DNA and RNA sequencing of a patient's tumor to inform treatment for these patients in real-time.

27 Oct 2017

Therapeutics News and Research

Targeting blood-clotting protein may help treat multiple sclerosis and other diseases

SENIOR trial: Shorter DAPT combined with Synergy stent superior to BMS in elderly patients

Discovery of genetic markers could guide individualized treatments for advanced prostate cancer

Pioneering heart device found to be safe and effective

Trial shows cost-effectiveness of TAVR compared to SAVR in intermediate risk patients with aortic stenosis

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

Repositive introduces first Global PDX Directory at AACR conference

Vedantra and Neon Therapeutics extend research alliance to develop impactful cancer therapies

Gene therapy prevents age-related learning and memory problems in mice

SU2C and its collaborators announce four teams to intercept cancer at earliest stages

New device holds potential for early detection of cavities

Biogen and Ionis awarded 2017 Prix Galien USA Award for SPINRAZA

Montmorency tart cherry juice found to help extend sleep time among adults 50 years and older

ACIST Medical Systems announces debut of next generation FFR solution

UC San Diego Health scientists help create ‘dream team’ to prevent pancreatic cancer

New findings offer promising druggable target to root out metastatic pancreatic cancer

Clinical trial shows promising results for treatment of patients with recurrent high-grade glioma

Novel consortium aims to create new paradigm of cancer drug discovery

New concise guide to pharmacology offers key information on major drug targets

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Advancing therapeutic biopolymer development eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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