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Research discovery advances efforts to replace damaged heart muscle

In a study that began in a pair of infant siblings with a rare heart defect, Johns Hopkins researchers say they have identified a key molecular switch that regulates heart cell division and normally turns the process off around the time of birth. Their research, they report, could advance efforts to turn the process back on and regenerate heart tissue damaged by heart attacks or disease.

4 Mar 2014

Novel scaffold protein regulates mu opioid receptor induced signaling activation

Researchers found initial confirmation that a novel scaffold protein previously unassociated with the mu opioid receptor (MOR) regulates MOR-induced signaling activation.

4 Mar 2014

Blocking Netrin-1 in immune system stops chronic inflammation and insulin resistance tied to obesity

Researchers at NYU Langone Medical Center have found that blocking the action of a key signaling molecule in the immune system known as Netrin-1 stalls chronic inflammation and insulin resistance tied to obesity and often derived from fatty diets.

4 Mar 2014

Research provides insight into biologic mechanisms that individual cancer cells use to metastasize to brain

New research from Memorial Sloan Kettering provides fresh insight into the biologic mechanisms that individual cancer cells use to metastasize to the brain.

4 Mar 2014

Scientists report major step forward in determining specific behavior of PP1 enzyme

In the Proceedings of the National Academy of Sciences, a team of scientists at Brown University reports a major step forward in determining the specific behavior of the ubiquitous enzyme PP1 implicated in a wide range of diseases including cancer.

4 Mar 2014

New research uncovers abnormal molecular signaling pathways for kidney failure

Prevention and reversal of chronic kidney disease is an urgent public health need. The disease affects 1 in 10 Americans, is debilitating and deadly, and existing drugs, at best, offer only mild delay in progression to end-stage kidney failure.

4 Mar 2014

3-D imaging of two different mouse models helps understand Apert Syndrome development

Three dimensional imaging of two different mouse models of Apert Syndrome shows that cranial deformation begins before birth and continues, worsening with time, according to a team of researchers who studied mice to better understand and treat the disorder in humans.

4 Mar 2014

Neuroscientists unlock a piece of puzzle in fight against Lou Gehrig's disease

Keck School of Medicine of USC neuroscientists have unlocked a piece of the puzzle in the fight against Lou Gehrig's disease, a debilitating neurological disorder that robs people of their motor skills.

4 Mar 2014

OPKO Health consolidated revenues increase about 30% to $20.7 million in Q4 2013

OPKO Health, Inc., a multi-national biopharmaceutical and diagnostics company, today reported operating and financial results for its 2013 fourth quarter and full year ended December 31, 2013.

4 Mar 2014

Research explores milk proteins for healthy aging and sports performance

The University of Limerick will take the lead in Phase 2 of Food for Health Ireland’s research programme to explore the role of milk proteins in healthy aging and performance nutrition.

4 Mar 2014

Atopix presents positive results of Phase IIb asthma study at AAAAI meeting

Atopix Therapeutics Ltd ("Atopix"), a biopharmaceutical company developing innovative CRTH2 antagonists for allergic disease, announced the results of a Phase IIb asthma study with their lead compound OC459 at the American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting , San Diego, California, USA on March 1st.

3 Mar 2014

Photoreactive compounds open new routes to treatment of neurological diseases

Photoreactive compounds developed by scientists of Ludwig-Maximilians-Universitaet (LMU) in Munich directly modulate nerve-cell function, and open new routes to the treatment of neurological diseases, including chronic pain and certain types of visual impairment.

3 Mar 2014

Scientists uncover key mechanism of gene regulation

In the cells of humans and other organisms, only a subset of genes are active at any given time, depending largely on the stage of life and the particular duties of the cell. Cells use different molecular mechanisms to orchestrate the activation and deactivation of genes as needed.

3 Mar 2014

3D structure of enzyme helps defend against bacteria

An essential weapon in the body's fight against infection has come into sharper view. Researchers at Princeton University have discovered the 3D structure of an enzyme that cuts to ribbons the genetic material of viruses and helps defend against bacteria.

3 Mar 2014

Researchers find unusual mutation strongly linked to rare liver cancer that affects teens

In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center (NYGC), an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults.

3 Mar 2014

Max Planck scientists identify new mechanisms in cellular stress response

When an organism is exposed to life-threatening conditions, it sounds the alarm and a cellular emergency program, the heat shock response, is initiated.

3 Mar 2014

Teen diagnosed with liver cancer explores genetic link to rare cancers

A father-daughter scientific collaboration that began after the daughter was diagnosed with a rare liver cancer has led to an important finding and could have broader implications for many other rare cancers. Their story is being published this week in a top tier journal, Science.

3 Mar 2014

PerkinElmer launches Lamina slide scanner for clearer visualization of protein biomarker in tissue

PerkinElmer, Inc., a global leader focused on the health and safety of people and the environment, today announced the launch of the Lamina multilabel slide scanner at the USCAP 2014 Annual Meeting.

3 Mar 2014

Researchers identify mutations in gene that can reduce risk of developing type 2 diabetes

An international team led by researchers at the Broad Institute and Massachusetts General Hospital (MGH) has identified mutations in a gene that can reduce the risk of developing type 2 diabetes, even in people who have risk factors such as obesity and old age.

3 Mar 2014

Heat shock protein may be involved in folding processes of tau protein

Proteins like the so-called heat shock protein Hsp90 play an important role in almost all processes within human cells. They help other proteins fold into their three-dimensional structure or return damaged proteins back into their proper shape.

3 Mar 2014

G Protein News and Research

Research discovery advances efforts to replace damaged heart muscle

Novel scaffold protein regulates mu opioid receptor induced signaling activation

Blocking Netrin-1 in immune system stops chronic inflammation and insulin resistance tied to obesity

Research provides insight into biologic mechanisms that individual cancer cells use to metastasize to brain

Scientists report major step forward in determining specific behavior of PP1 enzyme

New research uncovers abnormal molecular signaling pathways for kidney failure

3-D imaging of two different mouse models helps understand Apert Syndrome development

Neuroscientists unlock a piece of puzzle in fight against Lou Gehrig's disease

OPKO Health consolidated revenues increase about 30% to $20.7 million in Q4 2013

Research explores milk proteins for healthy aging and sports performance

Atopix presents positive results of Phase IIb asthma study at AAAAI meeting

Photoreactive compounds open new routes to treatment of neurological diseases

Scientists uncover key mechanism of gene regulation

3D structure of enzyme helps defend against bacteria

Researchers find unusual mutation strongly linked to rare liver cancer that affects teens

Max Planck scientists identify new mechanisms in cellular stress response

Teen diagnosed with liver cancer explores genetic link to rare cancers

PerkinElmer launches Lamina slide scanner for clearer visualization of protein biomarker in tissue

Researchers identify mutations in gene that can reduce risk of developing type 2 diabetes

Heat shock protein may be involved in folding processes of tau protein

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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