Antigen News and Research

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DN-101 may protect against major side effects of chemotherapy

Men with advanced prostate cancer who take an experimental, high-dose vitamin D pill with chemotherapy live about eight months longer than those receiving chemotherapy and placebo, according to a new study.

3 Nov 2005

New insight into the eradication of HIV in infected individuals receiving antiviral therapy

Antiviral therapy has been used to suppress HIV replication and has dramatically improved the clinical course of disease in affected patients. But the existence of viral reservoirs precludes the complete elimination of HIV from treated patients.

3 Nov 2005

Targeted drug delivery now possible using nanoparticle-apatamer conjugates

Ground-breaking results from researchers at Harvard Medical School and Massachusetts Institute of Technology (MIT), USA, disclosed at the 13th European Cancer Conference (ECCO) have shown for the first time that targeted drug delivery is possible using nanoparticle-apatamer conjugates.

3 Nov 2005

Cancer Vaccine - Synthetically generated glycopeptides from tumor cells can stimulate the formation of specific antibodies

Tumor cells and healthy somatic cells differ in the structures on their surfaces. In principle, it should thus be possible to develop a vaccine that causes a patient’s immune system to form antibodies that attack and destroy tumor cells while sparing healthy cells.

3 Nov 2005

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

Ground-breaking results from researchers at Harvard Medical School and Massachusetts Institute of Technology (MIT), USA, disclosed at the 13th European Cancer Conference (ECCO) in Paris have shown for the first time that targeted drug delivery is possible using nanoparticle-apatamer conjugates.

1 Nov 2005

Dendritic cells tricked into action against cancer

A new type of immunotherapy in which dendritic cells are tricked into action against cancer when they are exposed to harmless pieces of viruses and bacteria is described in the November issue of Cancer Research.

1 Nov 2005

Role of alpha tocopherol associated protein in prostate cancer

Researchers have identified a protein that disrupts an important signaling pathway in prostate cancer cells and suppresses growth of the cancer.

1 Nov 2005

Benefit of combining radiation and hormone therapy in the treatment of prostate cancer

Doctors in Canada have discovered that treating high-risk prostate cancer patients with radiation therapy and adding hormone therapy for more than one year allows patients to live longer, have better control of their prostate specific antigen levels and lowers the rate of death specifically from prostate cancer

1 Nov 2005

Better understanding of T cell response

Swedish and U.K. researchers report that an apparently "acute" human viral infection can cause a persistent, activated CD8+ T cell response a long time after patients have recovered.

1 Nov 2005

Yearly PSA test saves lives

Men who have a yearly blood test to examine their prostate specific antigen levels are nearly three times less likely to die from prostate cancer than those who don't have annual screenings, according to a study presented October 19, 2005, at the American Society for Therapeutic Radiology and Oncology's 47th Annual Meeting in Denver.

19 Oct 2005

New prostate cancer test far more accurate

At present in order to predict prostate cancer outcomes, doctors rely on measures that suggest how far the tumour has spread and how abnormal the cancer cells appear under the microscope.

18 Oct 2005

Researchers shed light on a key molecular switch in T helper cells

Defects in immune system cells called T helper cells may lead to diseases characterized by a faulty inflammatory response such as autoimmunity and asthma. Understanding the molecular steps involved in how T helper cells mature may help researchers develop treatments for these diseases.

17 Oct 2005

1G8 antibody signals prostate cancer cells to stop growing and die

Researchers at UCLA's Jonsson Cancer Center have uncovered the mechanism by which an antibody blocks the growth of prostate cancer in animal models, a discovery that could pave the way for development of a new molecularly targeted therapy.

17 Oct 2005

Discovery could help make cellular immunotherapy safer

Researchers at the University of Michigan's Comprehensive Cancer Center have discovered the secret weapon behind the most powerful form of cancer immunotherapy known to medicine.

16 Oct 2005

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via toll-like receptor -viral RNA interactions

Progressive disease after HIV infection is inversely correlated with the presence of plasmacytoid dendritic cells (pDCs), a subset of the dendritic cell family and the major producers of type 1 interferon in the body. High numbers of pDCs is related to successful control of HIV.

13 Oct 2005

New discoveries help explore the function of regulatory T cells in autoimmune disease and in cancer

More than 150 years after the discovery of Hassall's corpuscles in 1849, the function of these round blobs of cells in the human thymus gland has now been explained. The answer, in turn, ends an intense hunt for the origin of regulatory T cells that has been under way for years.

11 Oct 2005

Nabi Biopharmaceuticals granted Staphylococcus Antigen and Vaccine patent

Nabi Biopharmaceuticals has announced that it has been granted U.S. Patent No. 6,936,258 entitled "Staphylococcus Antigen and Vaccine" by the U.S. Patent and Trademark Office for the composition of a strategically important glycoprotein-based antigen (GP-1) associated with three Staphylococcal strains: S. epidermidis, S. haemolyticus and S. hominis.

11 Oct 2005

Colorectal cancer screening rates are too low

An intervention program designed to promote screening for colorectal cancer – and thereby decrease the number of cancers diagnosed - failed to increase screening rates in the managed care setting, a University of California - Los Angeles study has found.

10 Oct 2005

Tonsils reveal information that helps understand lupus

By snipping out and analyzing tiny samples of patients' tonsils, scientists have identified a key cellular checkpoint that is somehow bypassed in lupus patients, where harmful immune cells that normally are squelched by the body are mistakenly granted access.

9 Oct 2005

Kidney paired donation transplantation has graft survival rates equivalent to compatible live donor transplants

A preliminary study suggests that kidney paired donation transplantation, in which incompatible donor/recipient pairs exchange kidneys so that each recipient receives a compatible kidney, had graft survival rates equivalent to compatible live donor transplants, according to a study in the October 5 issue of JAMA: The Journal of the American Medical Association.

4 Oct 2005