Clinical Trial News and Research

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Georgetown University Medical Center announces launch of clinical trial for Lewy body dementia

Georgetown University Medical Center announces the launch of the only known therapeutic (disease modifying) clinical trial for Lewy body dementia, a neurological disorder that affects a million people in the United States for which there are no approved medications that modify the disease.

3 Jun 2019

People living with HIV have increased risk for heart diseases and face health challenges

Effective antiretroviral therapy has changed the human immunodeficiency virus (HIV) from a progressive, fatal disease to a chronic, manageable condition that is associated with higher rates of heart attacks, strokes, heart failure, sudden cardiac deaths, and other diseases compared to people without HIV, according to a new scientific statement from the American Heart Association published in the Association journal Circulation.

3 Jun 2019

Immunotherapy increases five-year survival rate of patients with advanced non-small cell lung cancer

In a study led by UCLA investigators, treatment with the immunotherapy drug pembrolizumab helped more than 15% of people with advanced non-small cell lung cancer live for at least five years - and 25% of patients whose tumor cells had a specific protein lived at least that long.

3 Jun 2019

Targeted therapy plus hormone therapy improves survival in premenopausal patients with advanced HR+ breast cancer

Adding the targeted therapy ribociclib to hormone therapy significantly improved overall survival (OS) in premenopausal patients with advanced hormone receptor-positive (HR+) breast cancer, according to results of the MONALEESA-7 Phase III clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

3 Jun 2019

Only few prostate cancer patients choosing active surveillance follow monitoring guidelines

Preliminary results from a University of North Carolina Lineberger Comprehensive Cancer Center study found that just 15 percent of a group of men in North Carolina with early-stage prostate cancer who choose active surveillance instead of treatment followed the recommended monitoring guidelines.

3 Jun 2019

Body's endocannabinoid system appears to be new target for drug development against OCD

The body's endocannabinoid system, due to the critical role it plays in regulating neurotransmitter signaling, is an enticing target for drug development against disorders associated with anxiety, stress, and repetitive behaviors, such as obsessive-compulsive disorder.

3 Jun 2019

A new approach to predict complications after surgery for patients with larynx cancer

A technique that illuminates blood flow during surgery predicted which head and neck cancer patients were likely to have issues with wound healing. It could enable surgeons to make adjustments during surgery or recovery to improve outcomes.

31 May 2019

Pre-surgical neoadjuvant treatment shows promise in trial for patients with operable NSCLC

For patients with operable non-small cell lung cancer, pre-surgical "neoadjuvant" treatment with an immune checkpoint inhibitor was well tolerated and, in many cases, caused significant tumor cell death in a large, multicenter clinical trial involving investigators at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and nine other research centers

31 May 2019

Researchers mobilize globally to improve smoking cessation tools as World No Tobacco Day approaches

More than 30 years after World No Tobacco Day was launched to raise awareness of the devastating health effects of tobacco use, there are still more than a billion smokers in the world.

31 May 2019

Study highlights the need to educate oncologists about molecular profiling

A questionnaire aimed at assessing how well community oncologists understand "molecular profiling" results from tumor specimens found that 69 percent of participants either said they don't know the answers, or they responded incorrectly.

31 May 2019

Randomized controlled trial introduces new psychotherapeutic approach to schizophrenia

A randomized controlled trial published in the current issue of Psychotherapy and Psychosomatics introduces a new psychotherapeutic approach to schizophrenia, based on psychological well-being.

31 May 2019

Research provides new options for treatment of multi-drug resistant infections

A new study, published in 'Antimicrobial Agents and Chemotherapy' conducted by a University of Liverpool led research consortium, has helped develop a new treatment option for some multi-drug resistant infections.

30 May 2019

Manuka honey could be useful in treating cystic fibrosis lung infection

Researchers at the Swansea University have shown that Manuka honey could be useful in treatment of deadly lung infections caused by antimicrobial resistant respiratory bacteria in cystic fibrosis (CF). The study titled, “Anti-pseudomonad Activity of Manuka Honey and Antibiotics in a Specialized ex vivo Model Simulating Cystic Fibrosis Lung Infection,” was published in the latest issue of the journal Frontiers of Microbiology.

30 May 2019

Researchers develop a standardized method for predicting transplant rejection

Researchers from The Westmead Institute for Medical Research have developed a standardized method of measuring the immune response in islet transplant recipients, helping predict patient outcomes.

29 May 2019

Energy drinks may increase blood pressure and risk of electrical disturbances in heart

Drinking 32 ounces of an energy drink in a short timespan may increase blood pressure and the risk of electrical disturbances in the heart, which affect heart rhythm, according to a small study published in Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association.

29 May 2019

Surgery can be beneficial for one type of primary central nervous system lymphoma

Through a systematic review of published studies going back 50 years, Johns Hopkins Medicine researchers say they have identified a distinct subtype of primary central nervous system lymphoma that should be considered for surgical removal, suggesting a major shift in how this type of tumor is evaluated and managed.

From Johns Hopkins Medicine 29 May 2019

PCRF awards £1.2M grants for new research projects tackling pancreatic cancer

Seven innovative research projects tackling pancreatic cancer have been awarded grants totalling £1.2M by the UK medical research charity, Pancreatic Cancer Research Fund.

28 May 2019

Study finds new evidence that it is unnecessary to fast before complete cholesterol test

A new study adds to the growing body of evidence that it is unnecessary for most patients to fast before having bloodwork done to measure lipid levels to determine risk of future cardiovascular events.

28 May 2019

Study demonstrates the concept of systemic gene therapy treatment for gamma-sarcoglycanopathy

Gamma-sarcoglycanopathy is one of the most common limb-girdle myopathies.

25 May 2019

Newly approved gene therapy for SMA is based on delivery vehicle discovered by Penn expert

James Wilson, MD, PhD, recalls being struck by the devastating toll of rare diseases as a young physician in the 1980s. He set out on a path to correct the genes that cause these conditions, including spinal muscle atrophy (SMA), the most common inherited fatal disease in infants.

25 May 2019

Clinical Trial News and Research

Georgetown University Medical Center announces launch of clinical trial for Lewy body dementia

People living with HIV have increased risk for heart diseases and face health challenges

Immunotherapy increases five-year survival rate of patients with advanced non-small cell lung cancer

Targeted therapy plus hormone therapy improves survival in premenopausal patients with advanced HR+ breast cancer

Only few prostate cancer patients choosing active surveillance follow monitoring guidelines

Body's endocannabinoid system appears to be new target for drug development against OCD

A new approach to predict complications after surgery for patients with larynx cancer

Pre-surgical neoadjuvant treatment shows promise in trial for patients with operable NSCLC

Researchers mobilize globally to improve smoking cessation tools as World No Tobacco Day approaches

Study highlights the need to educate oncologists about molecular profiling

Randomized controlled trial introduces new psychotherapeutic approach to schizophrenia

Research provides new options for treatment of multi-drug resistant infections

Manuka honey could be useful in treating cystic fibrosis lung infection

Researchers develop a standardized method for predicting transplant rejection

Energy drinks may increase blood pressure and risk of electrical disturbances in heart

Surgery can be beneficial for one type of primary central nervous system lymphoma

PCRF awards £1.2M grants for new research projects tackling pancreatic cancer

Study finds new evidence that it is unnecessary to fast before complete cholesterol test

Study demonstrates the concept of systemic gene therapy treatment for gamma-sarcoglycanopathy

Newly approved gene therapy for SMA is based on delivery vehicle discovered by Penn expert

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