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Humans have very individualized inflammatory responses to high-fat meal

People have very individualized inflammatory responses to eating a high-fat meal.

12 Sep 2019

New liquid biopsy test may be more predictive of patient's immunotherapy response

A new liquid biopsy test could detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating that it could help determine which patients are likely to respond to immune checkpoint inhibitors.

11 Sep 2019

A gene that acts as master regulator of schizophrenia identified

Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of schizophrenia during early human brain development.

11 Sep 2019

Gene coding error likely responsible for rare form of inherited 'short telomere' disease

By combing through the entire genetic sequences of a person with a lung scarring disease and 13 of the person’s relatives, Johns Hopkins Medicine researchers say they have found a coding error in a single gene that is likely responsible for a rare form of the disease and the abnormally short protective DNA caps on chromosomes long associated with it.

From Johns Hopkins Medicine 11 Sep 2019

Scientists discover new strain of group A streptococcus bacteria in England and Wales

A team of scientists led by Imperial College London have discovered a new strain of group A streptococcus bacteria.

11 Sep 2019

Genetic engineering could open possibilities for patients with Parkinson’s disease

People with Parkinson’s disease experience loss of dopamine-producing brain cells, leading to tremors, rigidity, bradykinesia, and postural instability, the primary symptoms of the disease.

11 Sep 2019

Long-term antibiotic use in preemies promotes drug-resistant gut bacteria

Very preterm infants are often sick and require antibiotic treatment to save their lives. However, when this form of therapy lasts for 20 months or more, it may affect the gut microbiome over the long-term in addition to its acute effects.

10 Sep 2019

Nanocapsules packed with gene-editing tools could be promising platform for many gene therapies

New tools for editing genetic code offer hope for new treatments for inherited diseases, some cancers, and even stubborn viral infections. But the typical method for delivering gene therapies to specific tissues in the body can be complicated and may cause troubling side effects.

10 Sep 2019

Liquid biopsies provide complete picture of genetic alterations linked to cancer drug resistance

Many patients see their tumors shrink in response to a drug, only to have them come back with a vengeance as they evolve to fend off the treatment. Oncologists want to be able to quickly detect cancer drug resistance as it emerges in their patients and identify another drug the tumors will still respond to.

10 Sep 2019

Salk researchers develop method to reveal epigenetic features of brain cells

The brain's prefrontal cortex, which gives us our ability to solve problems and plan ahead, contains billions of cells. But understanding the large diversity of cell types in this critical region, each with unique genetic and molecular properties, has been challenging.

10 Sep 2019

Lefthandedness genes change the way the brain develops

A new study has discovered four genes related to left-handedness, and the associated differences in the way the brain is organized. About a tenth of people are left-handed, making this a not uncommon trait. However, the new findings point to greater verbal fluency with this alternate version of the brain, compared to right-handedness.

6 Sep 2019

How tuberculosis progresses: genetic factors play a major role

There are almost 1.8 billion people with tuberculosis bacilli in their body, but only about 5% to 15% develop overt infection, usually within 18 months of initial exposure. The reason behind this selective progression has been sought for decades by scientists from a variety of fields.

5 Sep 2019

Researchers discover a molecule that regulates tumor development in different types of cancers

Researchers from the Josep Carreras Leukemia Research Institute, discover that a non-coding region of the genome originates a key molecule for the proliferation of tumors in breast cancer and some types of sarcoma.

5 Sep 2019

Genetic variants associated with adult obesity start playing a role during early childhood

Body mass index in infants, children and adults is influenced by different genetic factors that change as we age, according to a major new study.

5 Sep 2019

Large-scale study maps the genetic underpinnings of early TB progression

While the vast majority of the 1.8 billion people infected with the TB bacterium never experience active disease, an estimated 5 to 15 percent do develop full-blown infections--roughly half of them within 18 months of exposure.

4 Sep 2019

Researchers map uncharted area of genome using advanced imaging

Using advanced imaging techniques, researchers at the University of Colorado Anschutz Medical Campus have mapped a previously uncharted region of the human genome that gives rise to a variety of disease, setting the stage to potentially test for the conditions in the future.

4 Sep 2019

A factor that predicts prolonged survival in brain tumor uncovered

The discoveries in the cellular and molecular biology of cancer, the development of drugs against specific genetic mutations, and the emergence of immunotherapy are allowing the cure or improvement of the quality of life and life expectancy of patients with tumors.

3 Sep 2019

CRISPR-Cas9 successfully reverses type 2 diabetes in mice

Researchers have used CRISPR-Cas9 to treat obesity and type 2 diabetes in mice, a development that could eventually benefit humans.

3 Sep 2019

SATI gene editing could replace CRISPR

Scientists have developed a new gene editing tool called SATI that is safer than CRISPR.

2 Sep 2019

DNA methylation closely linked to telomere length

Aging is associated with multiple disease conditions. Recently it has been found that many of these illnesses are linked to the length of the telomeres at the ends of every chromosome. Telomere length (TL) is affected by both genetic and epigenetic contributions.

2 Sep 2019

Genome News and Research

Humans have very individualized inflammatory responses to high-fat meal

New liquid biopsy test may be more predictive of patient's immunotherapy response

A gene that acts as master regulator of schizophrenia identified

Gene coding error likely responsible for rare form of inherited 'short telomere' disease

Scientists discover new strain of group A streptococcus bacteria in England and Wales

Genetic engineering could open possibilities for patients with Parkinson’s disease

Long-term antibiotic use in preemies promotes drug-resistant gut bacteria

Nanocapsules packed with gene-editing tools could be promising platform for many gene therapies

Liquid biopsies provide complete picture of genetic alterations linked to cancer drug resistance

Salk researchers develop method to reveal epigenetic features of brain cells

Lefthandedness genes change the way the brain develops

How tuberculosis progresses: genetic factors play a major role

Researchers discover a molecule that regulates tumor development in different types of cancers

Genetic variants associated with adult obesity start playing a role during early childhood

Large-scale study maps the genetic underpinnings of early TB progression

Researchers map uncharted area of genome using advanced imaging

A factor that predicts prolonged survival in brain tumor uncovered

CRISPR-Cas9 successfully reverses type 2 diabetes in mice

SATI gene editing could replace CRISPR

DNA methylation closely linked to telomere length

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