Antigen News and Research

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Emergent Biosolutions' typhoid vaccine achieves positive results in Phase II clinical study

Emergent BioSolutions today announced positive results from a Phase II clinical study evaluating a new simplified dosing regimen for the company's next generation single dose oral typhoid vaccine. The results of the study were published in the August edition of the Journal of Infectious Diseases.

30 Aug 2005

Three-dimensional molecular structure of a promising malaria-vaccine component

An international team of scientists that includes a researcher from the U.S. Department of Energy's Brookhaven National Laboratory has determined the three-dimensional molecular structure of a promising malaria-vaccine component.

29 Aug 2005

New laboratory method for quickly detecting active anthrax proteins

A new laboratory method for quickly detecting active anthrax proteins within an infected blood sample at extremely low levels has been developed by researchers at the National Institute of Standards and Technology (NIST), the U.S. Army Medical Research Institute of Infectious Diseases and the National Cancer Institute.

29 Aug 2005

Carbohydrate-based vaccine against cancer?

Couldn't we be immunized against cancer? This sounds like a dream, but is in fact a thoroughly realistic research goal. American researchers have now taken an important step forward in the development of a cancer vaccine.

29 Aug 2005

New vaccine protects more effectively against tuberculosis

Max Planck researchers have uncovered the mechanism by which the new genetically engineered tuberculosis vaccine functions.

28 Aug 2005

New strategy to turn off the function of a special group of T cells to suppress immune response to tumors

A special stretch of genetic material may turn off the immune suppression that stymies attempts to fight cancer with a vaccine, said researchers at Baylor College of Medicine (BCM) at Houston.

26 Aug 2005

The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma

Research led by Dr. Anne Mueller at Stanford University School of Medicine demonstrates that successful eradication of Helicobacter may not prevent future aggressive gastric lymphoma since resting B cells are left behind.

25 Aug 2005

Experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma

Researchers at The University of Texas M. D. Anderson Cancer Center and the National Cancer Institute have found that an experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma, even though prior therapy had eliminated virtually all of the B cells thought necessary to mount such a defense.

22 Aug 2005

New hope for those deaf from immune system attack

A new study may one day help those deafened by immune system attack, and possibly also lead to a test that could show which patients may be helped by immediate steroid treatment.

16 Aug 2005

Body's own defense mechanism causes some of the most serious asthma symptoms

McGill University Health Centre (MUHC) scientists have discovered that our body's own defense mechanism causes some of the most serious asthma symptoms.

13 Aug 2005

Giving prostate cancer patients radiotherapy after surgery could help prevent the progression of their disease

When cancer is confined to the prostate, removal of the organ can successfully control the disease. However, for patients with cancer extending beyond the prostate the risk of recurrence after surgery can be 10–50%.

11 Aug 2005

No link between multiple vaccinations and infections

Over the years many concerns have been raised about chilhood vacinations, and one concern has been that multiple vaccinations 'use up' the immune system, so children are unable to fight off other illnesses.

10 Aug 2005

New prostate cancer test could save thousands from unnecessary surgery

Doctors at present lack a test that can distinguish fast-developing tumours that need urgent attention from slow-growing ones that are not a threat and need only watching, and as a result many men have operations that can leave them impotent and incontinent for prostate tumours that would never have killed them.

10 Aug 2005

Findings do not support the hypothesis of increased risk of nontargeted infectious disease hospitalization after childhood vaccination

New research does not support a belief that children receiving multiple vaccines increase their risk of hospitalization for a nontargeted infectious disease, according to a study in the August 10 issue of JAMA: The Journal of the American Medical Association.

9 Aug 2005

Lowering the current PSA threshold for recommending a prostate biopsy may subject millions of men to unnecessary, potentially harmful medical procedures

Lowering the current prostate-specific antigen (PSA) threshold for recommending a prostate biopsy may subject millions of men to unnecessary, potentially harmful medical procedures with no evidence that it will improve prostate cancer mortality rates, according to a new study in the August 3 issue of the Journal of the National Cancer Institute.

2 Aug 2005

Successful visceral leishmaniasis vaccine trial in dog

Visceral leishmaniasis, which is the most severe form of that group of diseases, affects 500 000 people in the world each year. It is caused by a protozoan, Leishmania infantum, transmitted by sand fly bites.

2 Aug 2005

Discovery that oxidative stress from pollen is as important as antigen exposure could lead to new therapies

For a person with allergies or asthma, breathing in pollen can be a very bad thing. Within minutes of inhalation by someone sensitive to their effects, these tiny particles can trigger severe inflammation of the respiratory passages, producing uncontrollable sneezing, coughing, or extreme shortness of breath -- symptoms agonizingly familiar to those who suffer from allergy and asthma attacks.

1 Aug 2005

Inhibitors of cellular enzymes could be developed for SARS treatment

Researchers from the University of Pennsylvania School of Medicine have found that inhibitors of an enzyme called cathepsin L prevent the SARS (severe acute respiratory syndrome) virus from entering target cells. SARS is caused by an emergent coronavirus. There is no effective treatment at this time.

1 Aug 2005

Key step in the entry of anthrax toxin into human cells

The work, which grew out of an ongoing effort to produce a better anthrax therapeutic, shows that the protective antigen component of the bacterial toxin plays an active role in transferring the other two components of the toxin through the cell membrane.

28 Jul 2005

Clinical factors can help predict the risk of prostate cancer death for patients following a radical prostatectomy

Clinical factors including the time to biochemical recurrence following surgery can help predict the risk of prostate cancer death for patients following a radical prostatectomy, according to a study in the July 27 issue of JAMA: The Journal of the American Medical Association.

27 Jul 2005

Antigen News and Research

Emergent Biosolutions' typhoid vaccine achieves positive results in Phase II clinical study

Three-dimensional molecular structure of a promising malaria-vaccine component

New laboratory method for quickly detecting active anthrax proteins

Carbohydrate-based vaccine against cancer?

New vaccine protects more effectively against tuberculosis

New strategy to turn off the function of a special group of T cells to suppress immune response to tumors

The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma

Experimental vaccine can prime the immune system to help fight an aggressive form of lymphoma

New hope for those deaf from immune system attack

Body's own defense mechanism causes some of the most serious asthma symptoms

Giving prostate cancer patients radiotherapy after surgery could help prevent the progression of their disease

No link between multiple vaccinations and infections

New prostate cancer test could save thousands from unnecessary surgery

Findings do not support the hypothesis of increased risk of nontargeted infectious disease hospitalization after childhood vaccination

Lowering the current PSA threshold for recommending a prostate biopsy may subject millions of men to unnecessary, potentially harmful medical procedures

Successful visceral leishmaniasis vaccine trial in dog

Discovery that oxidative stress from pollen is as important as antigen exposure could lead to new therapies

Inhibitors of cellular enzymes could be developed for SARS treatment

Key step in the entry of anthrax toxin into human cells

Clinical factors can help predict the risk of prostate cancer death for patients following a radical prostatectomy

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