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Gene therapy for rare diseases: A decade of progress and remaining challenges

A new review article in the peer-reviewed journal Human Gene Therapy summarizes the significant milestones in the development of gene therapy medicinal products that have facilitated the treatment of a significant number of rare diseases.

14 Nov 2023

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Researchers in Purdue University's College of Pharmacy are leveraging the dual roles played by an enzyme found in both cancer cells and T cells to create a novel cancer immunotherapy compound.

14 Nov 2023

Bioengineered human heart muscle cells and micro-tissues take flight to space

Mount Sinai's Cardiovascular Research Institute is sending bioengineered human heart muscle cells and micro-tissues into space for the first time on NASA's 29th SpaceX commercial resupply services mission, which launched Thursday, November 9.

14 Nov 2023

New app aims to ease burden on caregivers of dementia patients

With the number of Americans living with dementia expected to more than double to 13.8 million by 2060, two Regenstrief Institute research scientists and Indiana University professors have created an app to ease the burden on caregivers.

14 Nov 2023

COVID-19 triggers epigenetic alterations that drive lung damage and fatalities

The COVID-19 disease, due to infection with the SARS-CoV2 virus, became an international pandemic in 2020. To date, more than 770 million people have suffered from the disease and nearly 7 million of them have lost their life.

14 Nov 2023

Traffic emissions disrupt gene expression in human olfactory cells

Exposure to ultrafine particles from traffic alters the expression of many genes in human olfactory mucosa cells, a new study shows.

14 Nov 2023

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

14 Nov 2023

Introducing Luminescence 96: A Groundbreaking Advancement in Luminescence-Based Assays

With a vision to reenvision the lab and a passion for simplifying laboratory workflows with highly intuitive and functional designs, Byonoy launches Luminescence 96, further expanding its range of high-quality plate readers.

From Byonoy 14 Nov 2023

Placental inflammation's role in adult depression and heart disease

An expression signature related to inflammation expressed in Hofbauer cells in the placenta, calculating polygenic risk scores to predict its expression.

14 Nov 2023

Novel assay may improve detection and treatment of acute myeloid leukemia

A novel assay that detects a unique molecular marker in patients with acute myeloid leukemia (AML) may revolutionize the way this disease is detected and treated according to a new report in The Journal of Molecular Diagnostics published by Elsevier.

13 Nov 2023

Study reveals coadministered COVID-19 and flu vaccines effective, especially in seniors

The study in JAMA Network Open evaluates the effectiveness of simultaneously administering the Pfizer-BioNTech BNT162b2 BA.4/5 COVID-19 vaccine and seasonal influenza vaccines versus separate administration. Results suggest similar or slightly increased COVID-19 outcomes and lower influenza-related outcomes with coadministration, particularly in those aged 65 and above.

13 Nov 2023

AI-powered method could revolutionize cancer treatment by interpreting tumor tissue data

Researchers at Karolinska Institutet and SciLifeLab in Sweden have combined artificial intelligence (AI) techniques used in satellite imaging and community ecology to interpret large amounts of data from tumor tissue.

13 Nov 2023

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

In a JAMA Network Open study, researchers found no evidence of neuroinflammation or blood-brain barrier dysfunction in cerebrospinal fluid markers of individuals with post-COVID-19 condition and neuropsychiatric symptoms compared to controls. The study, which assessed cytokines, chemokines, and neuroinflammation markers, suggests that persistent central nervous system immune activation may not be the primary driver of neurological long COVID symptoms.

13 Nov 2023

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

13 Nov 2023

Unlocking the cure for hepatitis B virus: Challenges and opportunities

Hepatitis B virus (HBV) is a significant public health problem, with over 296 million people chronically infected worldwide.

13 Nov 2023

Initial high-risk antibody profile for antiphospholipid syndrome tends to remain high in pediatric patients, study finds

A new study by Hospital for Special Surgery (HSS) investigators has found that an initial high-risk antibody profile for antiphospholipid syndrome (APS) tended to remain high in pediatric patients.

13 Nov 2023

Researchers encourage flexible approach to blood transfusion decisions for heart attack patients with anemia

A National Institutes of Health-supported study found that the type of transfusion approach used to support adults who developed anemia after a heart attack did not make a significant difference in their likelihood of having another heart attack or dying within 30 days.

13 Nov 2023

B Cell News and Research

Gene therapy for rare diseases: A decade of progress and remaining challenges

Novel cancer immunotherapy compound degrades an enzyme found in cancer cells and T cells

Bioengineered human heart muscle cells and micro-tissues take flight to space

New app aims to ease burden on caregivers of dementia patients

COVID-19 triggers epigenetic alterations that drive lung damage and fatalities

Traffic emissions disrupt gene expression in human olfactory cells

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Introducing Luminescence 96: A Groundbreaking Advancement in Luminescence-Based Assays

Placental inflammation's role in adult depression and heart disease

Novel assay may improve detection and treatment of acute myeloid leukemia

Study reveals coadministered COVID-19 and flu vaccines effective, especially in seniors

AI-powered method could revolutionize cancer treatment by interpreting tumor tissue data

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Unlocking the cure for hepatitis B virus: Challenges and opportunities

Initial high-risk antibody profile for antiphospholipid syndrome tends to remain high in pediatric patients, study finds

Researchers encourage flexible approach to blood transfusion decisions for heart attack patients with anemia

Pioneering study finds predictive biomarker in lung adenocarcinoma

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

Willow bark may be the source of a new antiviral drug

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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