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Novel method to deliver drugs into inner ear restores hearing in deaf mice

An international team of researchers has developed a new method to deliver drugs into the inner ear. The discovery was possible by harnessing the natural flow of fluids in the brain and employing a little understood backdoor into the cochlea.

28 Jun 2023

Pyroptosis: A potential therapeutic target for lung cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

28 Jun 2023

Novel drug combination shows promise in treating pancreatic cancer

Mutations in the KRAS gene are the major driver of pancreatic cancer. The resulting protein controls multiple signaling pathways involved in cell growth and survival. In cancer, the gene is mutated to be permanently "on," driving cells to excessively multiply and form tumors.

28 Jun 2023

New radionuclide-based agent offers hope for treating a variety of cancers

A newly discovered radionuclide-based agent (CB-2PA-NT) has been shown to have high tumor uptake, sustained tumor retention, and high contrast in preclinical models, making it a prime candidate for a novel theranostics approach.

27 Jun 2023

New technique shows potential to generically treat several kinds of cancer

Researchers led by Katsunori Tanaka at the RIKEN Cluster for Pioneering Research (CPR) in Japan and Hiromitsu Haba at the RIKEN Nishina Center for Accelerator-Based Science (RNC) have developed a new technique that has the potential to generically treat several kinds of cancer, with fewer negative side effects than currently available methods.

27 Jun 2023

GREB1 gene key to liver cancer development, study finds

The development of hepatocellular carcinoma, liver cancer, is known to involve abnormal activation of a signaling pathway called Wnt; however, the underlying mechanisms have not been fully understood, until now.

27 Jun 2023

Illuminating how children inherit parents’ stressful experiences

Most of us learned in high school that people get half their genes from their father and half from their mother. That's true, but it turns out the way parents contribute to their offspring's genetics is more complicated—and more intriguing.

27 Jun 2023

AI model can help doctors determine the extent of cancer within the prostate

A new study shows that an artificial intelligence (AI) model co-developed by researchers in the UCLA Jonsson Comprehensive Cancer Center and department of Urology at UCLA can help doctors determine the extent of cancer within the prostate.

27 Jun 2023

UTHSC team poised to make a real-world impact on vulnerable cancer patients

A University of Tennessee Health Science Center research team is poised to make a real-world impact on vulnerable cancer patients, thanks to new support from the State of Tennessee.

27 Jun 2023

New digital assay can directly measure the presence of HIV in single drop of blood

A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies.

27 Jun 2023

Diabetes remission possible even without significant weight loss after gastric bypass surgery

More than half of patients with diabetes and a history of metabolic surgery (51%) experienced remission of their diabetes even if they did not achieve significant weight loss after surgery, according to a new study presented here today at the American Society for Metabolic and Bariatric Surgery 2023 Annual Scientific Meeting.

27 Jun 2023

New nanocarriers could revolutionize tuberculosis treatment

Therapy of the dangerous infectious disease of tuberculosis faces the challenge of pathogens frequently being resistant to several common antibiotics.

27 Jun 2023

Bariatric surgery reduces risk of MACE and death in patients with obstructive sleep apnea

Bariatric surgery, also called weight-loss or metabolic surgery, was associated with a 42% lower risk of major adverse cardiovascular events, including heart failure, heart attack, stroke, and atrial fibrillation in patients with moderate to severe obstructive sleep apnea (OSA), according to a new study from Cleveland Clinic and presented here today at the American Society for Metabolic and Bariatric Surgery 2023 Annual Scientific Meeting. Researchers also report metabolic surgery patients cut their risk of death by nearly 40%.

27 Jun 2023

Beyond expectations: study finds treatment success gap in drug-resistant Tuberculosis

Researchers performed a review of global treatment outcomes of drug-resistant Tuberculosis.

27 Jun 2023

ACEI therapy decreases the incidence of cardiac rupture after acute myocardial infarction

Announcing a new article publication for Cardiovascular Innovations and Applications journal. ACEI therapy decreases mortality in patients with acute MI.

26 Jun 2023

New kidney cancer model highlights molecular targets and genomic events that drive metastasis

Researchers at The University of Texas MD Anderson Cancer have engineered a new model of aggressive renal cell carcinoma (RCC), highlighting molecular targets and genomic events that trigger chromosomal instability and drive metastatic progression.

26 Jun 2023

Personalized dosing improves outcomes for men with metastatic castration-resistant prostate cancer

By monitoring early-response biomarkers in men undergoing 177Lu-PSMA prostate cancer treatment, physicians can personalize dosing intervals, significantly improving patient outcomes.

26 Jun 2023

World-renowned researcher receives top award for contributions to clinical psychopharmacology

Dennis Charney, MD, the Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai and President for Academic Affairs of the Mount Sinai Health System, has received the prestigious Donald Klein Lifetime Achievement Award from the American Society for Clinical Psychopharmacology (ASCP).

26 Jun 2023

Scientists identify potential biomarkers associated with positive immunotherapy response

Scientists at the UCLA Jonsson Comprehensive Cancer Center have identified potential new biomarkers that could indicate how someone diagnosed with metastatic melanoma will respond to immunotherapy treatment.

26 Jun 2023

New effort minimizes surgeon-specific standardized infection ratio

When excess surgical site infections (SSIs) were detected among neurosurgery patients at University of Pittsburgh Medical Center (UPMC) Mercy in 2019, infection preventionist Katie Palladino, MPH, CPH, CIC, partnered with a hospital neurosurgeon on a multidisciplinary quality and process improvement initiative that led to a steep drop in infection rates over a two-year period. Their successful initiative is being presented at the Association for Professionals in Infection Control and Epidemiology's (APIC's) Annual Conference in Orlando Florida, June 26-28.

26 Jun 2023

Therapy News and Research

Novel method to deliver drugs into inner ear restores hearing in deaf mice

Pyroptosis: A potential therapeutic target for lung cancer

Novel drug combination shows promise in treating pancreatic cancer

New radionuclide-based agent offers hope for treating a variety of cancers

New technique shows potential to generically treat several kinds of cancer

GREB1 gene key to liver cancer development, study finds

Illuminating how children inherit parents’ stressful experiences

AI model can help doctors determine the extent of cancer within the prostate

UTHSC team poised to make a real-world impact on vulnerable cancer patients

New digital assay can directly measure the presence of HIV in single drop of blood

Diabetes remission possible even without significant weight loss after gastric bypass surgery

New nanocarriers could revolutionize tuberculosis treatment

Bariatric surgery reduces risk of MACE and death in patients with obstructive sleep apnea

Beyond expectations: study finds treatment success gap in drug-resistant Tuberculosis

ACEI therapy decreases the incidence of cardiac rupture after acute myocardial infarction

New kidney cancer model highlights molecular targets and genomic events that drive metastasis

Personalized dosing improves outcomes for men with metastatic castration-resistant prostate cancer

World-renowned researcher receives top award for contributions to clinical psychopharmacology

Scientists identify potential biomarkers associated with positive immunotherapy response

New effort minimizes surgeon-specific standardized infection ratio

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