Clinical Trial News and Research

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Etomidate proves safer than ketamine for emergency intubations

Doctors treating seriously ill patients in an emergency setting may want to give the sedative etomidate, rather than ketamine, while placing a breathing tube, according to a randomized trial published Dec. 9 in the New England Journal of Medicine.

12 Dec 2025

Combining inhibitors and chemotherapy enhances treatment for aggressive leukemia subtypes

While patients with acute myeloid leukemia (AML) are routinely treated with chemotherapy and other cell-killing therapies, existing options do not lead to favorable clinical outcomes in all patients.

12 Dec 2025

Varenicline helps young people quit nicotine vaping regardless of cannabis use

Adolescent and young adult nicotine vaping has become an urgent public health concern, as 2024 marked the first year that nicotine vaping was the most initiated drug.

12 Dec 2025

Metabolic imaging enables early response prediction in bone-dominant metastatic breast cancer

A prospective, multicenter cancer clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) has validated an improved method for predicting treatment benefits in patients with hormone receptor-positive (HR+) metastatic breast cancer that has spread primarily or exclusively to the bones.

12 Dec 2025

Mass General Brigham launches AI company to enhance clinical trial matching

Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient's eligibility and enrolling them in a clinical trial.

12 Dec 2025

Acupuncture improves breast cancer survivors' perceived cognitive impairment

Real and sham acupuncture were more effective at improving breast cancer survivors' perceived cognitive impairment compared with usual care, while real acupuncture was superior to sham acupuncture in improving objective cognitive function, according to results from the randomized ENHANCE phase II clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

12 Dec 2025

Menopausal hormone therapy shows no added breast cancer risk for BRCA carriers

Using menopausal hormone therapy (MHT) was not associated with an increased risk of breast cancer in women with inherited mutations in the BRCA1 or BRCA2 genes, according to the results of a matched prospective analysis presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

12 Dec 2025

Mobile health intervention improves quality of life for adolescent and young adult breast cancer survivors

A mobile health (mHealth) intervention for adolescent and young adult breast cancer survivors that offered tailored support by monitoring electronic patient-reported outcomes (ePROs) significantly improved quality of life and symptoms related to vaginal and arm problems, according to results from a randomized clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

12 Dec 2025

Most clinical trials fail to reflect America’s racial and ethnic diversity

A new study finds just 6% of clinical trials used to approve new drugs in the U.S. reflect the country's racial and ethnic makeup, with an increasing trend of trials underrepresenting Black and Hispanic individuals.

12 Dec 2025

Advance care planning improves with automated patient outreach strategies

A strategy for advance care planning (ACP) that included automated outreach from staff who contacted patients to offer assistance significantly boosted the number of patients who completed documentation outlining their wishes in times of serious illness, new research finds.

11 Dec 2025

Preoperative MRI offers no survival benefit for early-stage breast cancer patients

Patients with stage 1 or 2, hormone receptor (HR)-negative breast cancer had similar five-year rates of locoregional recurrence whether or not they underwent preoperative breast magnetic resonance imaging (MRI) in addition to diagnostic mammography to determine the extent of their cancer, according to results from the phase III Alliance A011104/ACRIN 6694 clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

11 Dec 2025

Single-dose pill shows promise against antibiotic-resistant gonorrhoea

A single-dose oral medication called zoliflodacin shows promise as a new treatment for antibiotic-resistant gonorrhoea, according to a phase 3 clinical trial published in The Lancet.

11 Dec 2025

Proton therapy improves survival in oropharyngeal cancer patients

A new study published today in The Lancet showed a significant survival benefit for patients with oropharyngeal cancers who were treated with proton therapy (IMPT) compared to those treated with traditional radiation therapy (IMRT).

11 Dec 2025

Cleveland Clinic reports promising results for breast cancer vaccine from final Phase 1 data

Cleveland Clinic researchers are presenting final Phase 1 data from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

11 Dec 2025

Preoperative radiation may enhance treatment response in patients with HR-positive, HER2-negative breast cancer

Preoperative radiation improved T-cell infiltration (TCI) in patients with hormone receptor (HR)-positive, HER2-negative breast cancer when administered in combination with pembrolizumab (Keytruda) and chemotherapy and led to improved treatment responses prior to surgery, according to the results of the phase II P-RAD clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

11 Dec 2025

Skipping sentinel lymph node biopsy may be safe for some early-stage breast cancer patients

Skipping sentinel lymph node biopsy (SLNB) in patients with clinically node-negative, hormonal receptor (HR)-positive, HER2-negative early-stage breast cancer did not compromise regional control or survival after a median five years of follow-up, according to results from the BOOG 2013-08 phase III clinical trial, presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

11 Dec 2025

Antibody therapy clears residual multiple myeloma in early trial

Treatment with an immune and cancer cell-targeting antibody therapy eradicates residual traces of the blood cell cancer multiple myeloma, according to interim results from a clinical trial conducted by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.

10 Dec 2025

Van Andel Institute and Cure Parkinson's extend major Parkinson's drug trial initiative

Van Andel Institute and Cure Parkinson's have renewed a funding agreement to support the International Linked Clinical Trials Program, the world's largest drug repurposing clinical trial initiative for Parkinson's disease.

10 Dec 2025

Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) delayed disease progression in patients with HER2-positive metastatic breast cancer, potentially extending time off chemotherapy, according to results from the phase III clinical trial HER2CLIMB-05 presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

10 Dec 2025

Next-generation oral SERD therapy lowers the risk of breast cancer recurrence

In an international study led by UCLA, researchers have shown that giredestrant, a next-generation oral selective estrogen receptor antagonist and degrader (SERD), when given as an adjuvant therapy for early-stage (1-3) hormone receptor (HR)-positive, HER2-negative breast cancer, significantly lowered the risk of the disease returning when compared with standard hormone therapies long considered the backbone of treatment.

10 Dec 2025

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Clinical Trial News and Research

Etomidate proves safer than ketamine for emergency intubations

Combining inhibitors and chemotherapy enhances treatment for aggressive leukemia subtypes

Varenicline helps young people quit nicotine vaping regardless of cannabis use

Metabolic imaging enables early response prediction in bone-dominant metastatic breast cancer

Mass General Brigham launches AI company to enhance clinical trial matching

Acupuncture improves breast cancer survivors' perceived cognitive impairment

Menopausal hormone therapy shows no added breast cancer risk for BRCA carriers

Mobile health intervention improves quality of life for adolescent and young adult breast cancer survivors

Most clinical trials fail to reflect America’s racial and ethnic diversity

Advance care planning improves with automated patient outreach strategies

Preoperative MRI offers no survival benefit for early-stage breast cancer patients

Single-dose pill shows promise against antibiotic-resistant gonorrhoea

Proton therapy improves survival in oropharyngeal cancer patients

Cleveland Clinic reports promising results for breast cancer vaccine from final Phase 1 data

Preoperative radiation may enhance treatment response in patients with HR-positive, HER2-negative breast cancer

Skipping sentinel lymph node biopsy may be safe for some early-stage breast cancer patients

Antibody therapy clears residual multiple myeloma in early trial

Van Andel Institute and Cure Parkinson's extend major Parkinson's drug trial initiative

Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Next-generation oral SERD therapy lowers the risk of breast cancer recurrence

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