DNA Damage News and Research

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Genetic screening could be effective at detecting undiagnosed cases of prostate cancer

Genetic screening for prostate cancer in GP surgeries could be effective at picking up otherwise undiagnosed cases of the disease, a new pilot study shows.

31 May 2020

Rejuvenated fibroblasts could be used in regenerative medicine, stem cell engineering

Fibroblasts are the most common connective tissue cells. They produce the structural framework for animal tissues, synthesize the extracellular matrix and collagen, and play a critical role in wound healing.

26 May 2020

Researchers identify genetic mechanisms that produce radioresistance in cancer cells

Cancer stem cells are a cell type that was previously little known. They are resistant to irradiation and prevent the effective treatment of many types of cancer. A research group from Innsbruck has now identified two genetic mechanisms that produce this radioresistance.

26 May 2020

New genomic method helps obtain high-resolution maps of DNA in the cell nucleus

Researchers at Karolinska Institutet in Sweden have developed a new sequencing method that makes it possible to map how DNA is spatially organised in the cell nucleus - revealing which genomic regions are at higher risk of mutation and DNA damage.

26 May 2020

Novel LED irradiation system aims to kill microorganisms with UVC light

A novel LED irradiation system developed by the Ferdinand-Braun-Institut aims to kill microorganisms with ultra-short wave UV light - without side effects. Prototype handed over to the Charité for initial testing.

25 May 2020

Study uncovers the role of DNA repair in preserving egg quality

A Monash University study has uncovered the role DNA repair plays in preserving egg quality, offering hope for women whose eggs may be damaged through treatments such as radiation and chemotherapy.

22 May 2020

Scientists create a detailed map of how carcinogens trigger breast cancer development

In the most comprehensive review to date of how breast cancer develops, scientists have created a detailed map that describes the many ways in which environmental chemicals can trigger the disease.

21 May 2020

New technique reveals potentially treatable mutations in subset of prostate cancer patients

Prostate cancer patients who do not respond well to PSMA-targeted therapy often have potentially treatable mutations in their DNA damage-repair genes, according to research published in the May issue of The Journal of Nuclear Medicine.

20 May 2020

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions.

18 May 2020

New study sheds light on the cause of stem cell mutations

Research from the University of Sheffield has given new insight into the cause of mutations in pluripotent stem cells and potential ways of stopping these mutations from occurring.

15 May 2020

Molecular imaging can help identify treatment response in neuroendocrine tumor patients

A new proof-of-concept study published in the May issue of The Journal of Nuclear Medicine has demonstrated that molecular imaging can be used for identifying early response to 177Lu-DOTATATE treatment in neuroendocrine tumor patients.

14 May 2020

Scientists uncover important functions of a special protein during cell division

In a new study, researchers from the University of Copenhagen have discovered two important functions of a protein called RTEL1 during cell division.

12 May 2020

Researchers identify transcription factor that preserves the genomic integrity of germline

The germline is the cell lineage of an organism that passes on its genetic material to its progeny. Genetic damage to the germline can cause developmental defects and even death of that same progeny.

7 May 2020

OXGENE™ reports third consecutive year of 100% year on year revenue growth

OXGENE™ has more than doubled its annual revenue in the financial year just closed, in the third consecutive year of 100% year on year revenue growth.

From OXGENE 6 May 2020

Wyss Institute and Cytosurge collaborate to improve CRISPR multiplexing

Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG, a company manufacturing unique high-precision nanotechnology instruments, announced that they will collaboratively investigate CRISPR-based approaches to more effectively introduce multiple edits into the genome of single cells, while minimizing CRISPR-related toxicity.

4 May 2020

Real-time monitoring of biochemical processes on DNA using infrared spectroscopy

DNA damage in general and DNA strand breaks in particular occur every day in all cells of the human body.

3 May 2020

DNA damage and inaccurate repair mechanisms jointly cause mutational signatures

Researchers at EMBL's European Bioinformatics Institute, the University of Dundee and the Wellcome Sanger Institute analysed over 2700 genomes from C. elegans worms in order to better understand the causes of mutations.

2 May 2020

Cell division and its role in cancer development

To replace aging and worn cells, the body primarily uses a process called mitosis, in which one cell divides into two. When a cell is ready to divide, it duplicates its DNA so a complete copy is available for each of the daughter cells.

30 Apr 2020

Researchers recreate how toxins from smoking cause DNA damage

Researchers from the University of York have recreated how toxins from smoking cause unique patterns of DNA damage.

28 Apr 2020

Immunotherapy before surgery may help eradicate high-risk breast cancer

A new study led by Yale Cancer Center researchers shows women with high-risk HER2-negative breast cancer treated before surgery with immunotherapy, plus a PARP inhibitor with chemotherapy, have a higher rate of complete eradication of cancer from the breast and lymph nodes compared to chemotherapy alone.

28 Apr 2020

DNA Damage News and Research

Genetic screening could be effective at detecting undiagnosed cases of prostate cancer

Rejuvenated fibroblasts could be used in regenerative medicine, stem cell engineering

Researchers identify genetic mechanisms that produce radioresistance in cancer cells

New genomic method helps obtain high-resolution maps of DNA in the cell nucleus

Novel LED irradiation system aims to kill microorganisms with UVC light

Study uncovers the role of DNA repair in preserving egg quality

Scientists create a detailed map of how carcinogens trigger breast cancer development

New technique reveals potentially treatable mutations in subset of prostate cancer patients

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

New study sheds light on the cause of stem cell mutations

Molecular imaging can help identify treatment response in neuroendocrine tumor patients

Scientists uncover important functions of a special protein during cell division

Researchers identify transcription factor that preserves the genomic integrity of germline

OXGENE™ reports third consecutive year of 100% year on year revenue growth

Wyss Institute and Cytosurge collaborate to improve CRISPR multiplexing

Real-time monitoring of biochemical processes on DNA using infrared spectroscopy

DNA damage and inaccurate repair mechanisms jointly cause mutational signatures

Cell division and its role in cancer development

Researchers recreate how toxins from smoking cause DNA damage

Immunotherapy before surgery may help eradicate high-risk breast cancer

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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