Endoplasmic reticulum (ER) News and Research

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Researchers discover how tamoxifen-resistant breast-cancer cells grow and proliferate

A study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has discovered how tamoxifen-resistant breast-cancer cells grow and proliferate.

31 Aug 2012

Stowers investigators define factors that regulate size of cellular fat pools

As the national waistline expands, so do pools of intra-cellular fat known as lipid droplets. Although most of us wish our lipid droplets would vanish, they represent a cellular paradox: on the one hand droplets play beneficial roles by corralling fat into non-toxic organelles. On the other, oversized lipid droplets are associated with obesity and its associated health hazards.

30 Aug 2012

Janssen licenses rights to Depomed's Acuform gastric retentive drug delivery technology

Depomed, Inc. today announced that Janssen Pharmaceuticals, Inc., has licensed rights to Depomed's Acuform gastric retentive drug delivery technology.

28 Aug 2012

Tris Pharma joins Perrigo to launch first ever store brand ER liquid cough/cold product

Perrigo Company and Tris Pharma, Inc. today announced the commercial launch of a major new store brand product. The new product is equivalent to Delsym extended–release oral liquid suspension containing dextromethorphan polistirex and will be marketed under major U.S. retailer and wholesalers' store brands or own label brands.

27 Aug 2012

Update on Merck's development programs for vorapaxar, ER niacin/laropirprant and anacetrapib

Merck today provided an update on the development programs for vorapaxar, extended release niacin/laropirprant (MK524A, Tredaptive) and anacetrapib in association with the European Society of Cardiology (ESC) meeting in Munich.

27 Aug 2012

Food insecure HIV-infected poor people more likely to visit ERs

UCSF researchers found that poor HIV-infected individuals living in San Francisco are significantly more likely to visit emergency rooms and to have hospital stays if they lack access to food of sufficient quality and quantity for a healthy life.

23 Aug 2012

Viewpoints: Medicare as a 401(K) plan; Health doublespeak

Older adults are understandably anxious about the political sniping over the future financing of Medicare. That is precisely the intention of the presidential campaigns. Yet the cross-fire over who will cut Medicare by how much sidesteps a critical issue about the future of our medical care: If we must ration our care to hold down costs in the future, how can we do it in a fair, efficient and transparent way?

23 Aug 2012

Research explores impact of radiotherapy in older women with low risk of breast cancer recurrence

A Rhode Island Hospital radiation oncologist says in a new editorial that research exploring the impact of radiotherapy in older women with low risk of breast cancer recurrence has little effect on actual clinical decisions.

22 Aug 2012

Wockhardt receives final FDA approval for Felodipine ANDA to treat hypertension

Pharmaceutical and biotechnology major Wockhardt has received final approval from the United States Food & Drug Administration (US FDA) for marketing extended-release tablets containing 2.5mg, 5mg and 10mg Felodipine, which are used in treating hypertension.

22 Aug 2012

Late heart rejection is in decline in children, mortality the same

The rate of heart transplant rejection after 1 year has decreased in pediatric patients in recent years compared with the early 1990s, report researchers who add that, despite this, mortality rates in these patients have stayed the same.

16 Aug 2012

HCA's profit trail: Billing, staffing and ER care changes

HCA's robust profit growth has raised the value of the firms' holdings to nearly three and a half times their initial investment in the $33 billion deal. The financial performance has been so impressive that HCA has become a model for the industry.

16 Aug 2012

Novel method identifies new oncogene that contributes to development of cancer

A team of researchers at Case Western Reserve University School of Medicine, led by Dr. Mark W. Jackson, have developed a novel method to identify genes that, when overexpressed, make normal cells behave like cancer cells.

14 Aug 2012

Positive results from Acorda post-marketing commitment study of dalfampridine-ER for MS

Acorda Therapeutics, Inc. today announced top line results from a post-marketing commitment study evaluating a 5mg dose of dalfampridine-ER to improve walking in people with multiple sclerosis. The study failed to confirm efficacy of the 5mg dose.

13 Aug 2012

Highlights: New reports of problems at Parkland Hospital in Dallas; Mammogram rates did not rise under expanded Mass. coverage

Federal safety monitors produced a harsher critique of Parkland Memorial Hospital's reform efforts than recently portrayed by the hospital, finding ongoing dangers to patients from a botched surgery, medication errors and emergency care failures. Those problems, cited in a June compliance report obtained by The Dallas Morning News, were not disclosed in a Parkland summary released to The News two weeks ago.

12 Aug 2012

Researchers uncover new key player in amplifying stress in early stages of diabetes

At its most fundamental level, diabetes is a disease characterized by stress—microscopic stress that causes inflammation and the loss of insulin production in the pancreas, and system-wide stress due to the loss of that blood-sugar-regulating hormone.

9 Aug 2012

Study: ER overcrowding a problem for care at Calif. hospitals serving many minorities

A new study says California hospitals in areas with large minority populations are disproportionately affected by overcrowding at ERs -- often leading to ambulance diversion, delayed care and poorer health outcomes for patients.

8 Aug 2012

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes.

8 Aug 2012

Minorities more at risk of being impacted by ER crowding

Hospitals in areas with large minority populations are more likely to be overcrowded and to divert ambulances, delaying timely emergency care, according to a multi-institutional study focused on California.

7 Aug 2012

Roundup: Most high-ranking Iowa gov't employees to pay more for health care; Federal judge strikes Fla. law on docs asking about guns

The New Jersey state Legislature endorsed a constitutional amendment Monday requiring judges to contribute more to their government benefits, sending to voters an issue that some consider a linchpin of judicial independence. In a rare midsummer voting session, lawmakers responded quickly and almost unanimously to a state Supreme Court decision last week that said judges can't be forced to pay more for pension and health benefits, as other government workers were in a historic 2011 law.

31 Jul 2012

Array BioPharma announces positive results from ARRY-797 Phase 2 trial on osteoarthritis

Array BioPharma today announced that ARRY-797 met its primary endpoint in a randomized, placebo-controlled and active-controlled (oxycodone ER) Phase 2 clinical trial in 157 osteoarthritis patients suffering from moderate to severe knee pain despite the use of non-steroidal anti-inflammatory drugs (NSAIDs).