Mouse Model News and Research

RSS

Breakthrough antibiotic targets gum disease without harming microbiome

The ADA Forsyth Institute, a leading oral health research organization, and Flightpath Biosciences Inc. are excited to announce a groundbreaking discovery in the fight against severe gum disease and related systemic conditions.

4 Sep 2024

Study uncovers key enzyme link between obesity and atrial fibrillation

A cellular link between obesity and atrial fibrillation - a heart condition that afflicts over 33 million people worldwide - presents a promising target for new therapies, researchers from the University of Illinois Chicago report.

4 Sep 2024

Study shows how troriluzole can target early-stage alterations associated with Alzheimer's

In a recent development in Alzheimer's disease research, Auburn University scientists have studied a new drug, troriluzole, that can prevent brain changes leading to memory loss and cognitive decline in a mouse model of the disease.

3 Sep 2024

Delayed antiviral treatment still beneficial for immunocompromised COVID-19 patients

Starting antiviral treatment as late as 14 days after infection with SARS-CoV-2 may still be beneficial in hosts with compromised immune systems, who are at greatest risk of developing severe COVID-19, according to researchers in the Center for Translational Antiviral Research at Georgia State University's Institute for Biomedical Sciences.

3 Sep 2024

Penn research uncovers key biomarker for diagnosing sarcoidosis

Sarcoidosis is a rare systemic disease that afflicts an estimated 200,000 people in the US, more often people who are Black and more women than men, particularly when it causes chronic skin disease.

3 Sep 2024

NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

In a new study, clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) have demonstrated the use of exosomes to successfully target squamous cell cancer tumours that are usually resistant to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Their research is the first where exosomes have been applied to target TKI-resistant cancers in Singapore. The findings were published in the journal Developmental Cell last month.

2 Sep 2024

New consensus on assessing carcinogenic risks of gene therapies

A new article in the peer-reviewed journal Human Gene Therapy describes the consensus reached by invited experts who participated in a meeting to evaluate the potential carcinogenicity of gene therapies.

30 Aug 2024

16 promising postdoctoral scientists awarded Damon Runyon Fellowships for cancer research

The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows, exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

28 Aug 2024

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

The study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries.

27 Aug 2024

How diet shapes gut microbiota and affects brain function

Researchers discuss the diet-microbiota-gut-brain axis, which describes the role of both diet and gut microbiota composition on cognitive and emotional health.

26 Aug 2024

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

A Ludwig Cancer Research study has identified a metabolic switch in the immune system's T cells that is essential to the generation of memory T cells - which confer lasting immunity to previously encountered pathogens - and a T cell subtype found in tumors that drives anti-tumor responses during immunotherapy.

23 Aug 2024

T cells influence memory of innate immune cells, research shows

Research from Radboud University Medical Center reveals that T cells from the adaptive immune system can manipulate the memory of innate immune cells.

22 Aug 2024

mRNA therapy shows promise for maple syrup urine disease

Researchers from the University of Pennsylvania, Perelman School of Medicine, Gene Therapy Program, and Moderna, have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease (MSUD).

22 Aug 2024

Breakthrough compound targets appetite and tau protein in obesity and Alzheimer's

Scientists on the team of Dr Lenka Maletínská have developed a promising new compound derived from one of the peptides naturally occurring in the brain.

21 Aug 2024

The role of the gut microbiota in multiple sclerosis: A scientometric analysis reveals key research trends

Researchers examine the relationship between gut microbiota and multiple sclerosis.

21 Aug 2024

UC Davis researchers unveil pathway for Salmonella's gut invasion

How do bad bacteria find entry points in the body to cause infection? This question is fundamental for infectious disease experts and people who study bacteria.

20 Aug 2024

Study reveals time-of-day impact on cerebral malaria severity

A discovery by McGill-affiliated researchers could lead to more effective treatment of malaria and other parasitic diseases.

19 Aug 2024

Two studies uncover how immunotherapies work together to activate immune responses in melanoma

Two studies published in the latest issue of the journal Cell by University of Pittsburgh researchers uncover how immunotherapies targeting the immune checkpoints PD1 and LAG3 work together to activate immune responses.

13 Aug 2024

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Most people wouldn't think twice after seeing sugar spilled on a counter. But for someone with a history of cocaine use, this visual cue could trigger powerful associations with their past drug use and a compulsive urge to seek the drug.

9 Aug 2024

Alcohol use disorders in parents linked to accelerated aging in children

Researchers at the Texas A&M School of Veterinary Medicine and Biomedical Sciences (VMBS) have discovered that parents who struggle with alcohol use disorders can pass along symptoms of early aging to their children, affecting them well into adulthood.

8 Aug 2024

Mouse Model News and Research

Breakthrough antibiotic targets gum disease without harming microbiome

Study uncovers key enzyme link between obesity and atrial fibrillation

Study shows how troriluzole can target early-stage alterations associated with Alzheimer's

Delayed antiviral treatment still beneficial for immunocompromised COVID-19 patients

Penn research uncovers key biomarker for diagnosing sarcoidosis

NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

New consensus on assessing carcinogenic risks of gene therapies

16 promising postdoctoral scientists awarded Damon Runyon Fellowships for cancer research

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

How diet shapes gut microbiota and affects brain function

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

T cells influence memory of innate immune cells, research shows

mRNA therapy shows promise for maple syrup urine disease

Breakthrough compound targets appetite and tau protein in obesity and Alzheimer's

The role of the gut microbiota in multiple sclerosis: A scientometric analysis reveals key research trends

UC Davis researchers unveil pathway for Salmonella's gut invasion

Study reveals time-of-day impact on cerebral malaria severity

Two studies uncover how immunotherapies work together to activate immune responses in melanoma

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Alcohol use disorders in parents linked to accelerated aging in children

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News