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Adoptive T-cell therapy targeting MAGE-A4 achieves responses in patients with multiple solid tumors

The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

29 May 2020

Using functional MRI to demonstrate neural suppression in autism

According to the National Autism Association, people with autism spectrum disorder (ASD) may experience sensory hypersensitivity.

29 May 2020

UMSOM scientists develop experimental rapid diagnostic test for COVID-19

Scientists from the University of Maryland School of Medicine (UMSOM) developed an experimental diagnostic test for COVID-19 that can visually detect the presence of the virus in 10 minutes.

29 May 2020

Targeted therapy tepotinib shows durable response in NSCLC patients with METex14 skipping mutation

Patients with advanced non-small cell lung cancer (NSCLC) and the MET exon 14 (METex14) skipping mutation had a 46.5% objective response rate to the targeted therapy drug tepotinib, as shown in a study published today in the New England Journal of Medicine and presented at the 2020 American Society of Clinical Oncology Annual Meeting ASCO20 Virtual Meeting (Abstract 9556 - Poster 322) by researchers from The University of Texas MD Anderson Cancer Center.

29 May 2020

Targeted therapy pralsetinib shows high response rates in patients with RET fusion-positive cancers

The targeted therapy pralsetinib appears to have high response rates and durable activity in patients with a broad variety of tumors harboring RET gene fusions, according to results from the international Phase I/II ARROW trial, led by researchers at The University of Texas MD Anderson Cancer Center.

29 May 2020

Addition of monoclonal antibody to trimodality therapy offers no benefit in HER2 over expressing esophageal cancer

Results of the NRG Oncology clinical trial RTOG 1010 indicated that the addition of the monoclonal antibody trastuzumab to neoadjuvant trimodality treatment did not improve disease-free survival outcomes for patient with HER2 overexpressing local and locally advanced esophageal adenocarcinoma.

29 May 2020

UTHSC researcher awarded NIH grant to study age-related multimorbidity

A UTHSC researcher has been awarded an R15 grant from the National Institutes of Health for her work to identify and understand trends in age-related multimorbidity.

29 May 2020

Study finds nitrous oxide use during labor to be safe with rare side effects

Researchers at the University of Colorado College of Nursing and the School of Medicine Department of Anesthesiology at the Anschutz Medical Campus found that the use of nitrous oxide as a pain relief option for individuals in labor is safe for newborn children and laboring individual, and converting to a different form of pain relief such as an epidural or opioid is influenced by a woman's prior birth history and other factors.

29 May 2020

New technology developed to map cholesterol metabolism in the brain

A team of researchers led by Swansea University have developed new technology to monitor cholesterol in brain tissue which could uncover its relation to neurodegenerative disease and pave the way for the development of new treatments.

29 May 2020

Study analyzes cancer diagnosis in children with birth defects

Scientific studies suggest that children with birth defects are at increased risk of cancer. However, it has not been assessed whether the type of cancer, the age at which they are diagnosed or the extent of cancer spread at the time of diagnosis, is different for children with birth defects compared to children without birth defects.

29 May 2020

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer's disease finds that it is safe and well-tolerated, and researchers say the drug should be tested in a larger study to further determine its safety and efficacy as a potential disease-modifying strategy.

29 May 2020

Using gene therapy to help the body to make its own cancer drugs

Imagine that we could instruct our bodies to make the drugs they need themselves. The gene technology that makes this possible is called mRNA therapy, which may become a major tool in the treatment of multiple diseases.

29 May 2020

NIH funding supports research on first therapeutic drug to regenerate heart tissue

With funding from the National Institutes of Health, University of Arkansas researchers hope to develop the first therapeutic drug that can regenerate heart tissue.

29 May 2020

A Senator from Arizona emerges as a pharma favorite

Sen. Kyrsten Sinema formed a congressional caucus to raise "awareness of the benefits of personalized medicine" in February. Soon after that, employees of pharmaceutical companies donated $35,000 to her campaign committee.

29 May 2020

As COVID cuts deadly path through Indiana prisons, inmates say symptoms ignored

Scottie Edwards died of COVID-19 just weeks before he would have gotten out of the Westville Correctional Facility in Indiana.

29 May 2020

Changes in gut mucus are linked to brain disorders

Mucus is the first line of defense against bad bacteria in our gut. But could it also be part of our defense against diseases of the brain?

29 May 2020

Hate unmasked in America

"You are the most selfish f—ing people on the planet." I jerked my head to the left, where I saw a neighbor glaring at us from his driveway while unloading groceries from his trunk.

29 May 2020

Researchers review all clinical and research findings related to COVID-19

Due to the devastating worldwide impact of COVID-19, the illness caused by the SARS-CoV-2 virus, there has been unprecedented efforts by clinicians and researchers from around the world to quickly develop safe and effective treatments and vaccines.

29 May 2020

Study shows how toxic protein leads to neuronal death and dementia

Toxic versions of the protein tau are believed to cause the death of neurons of the brain in Alzheimer's disease.

29 May 2020

Study: Glucocorticoids are harmful for patients suffering from viral respiratory infections

Glucocorticoids are widely used in treating acute respiratory distress syndrome (ARDS) despite there being no indisputable scientific evidence of their effectiveness.

29 May 2020

Research News and Research

Adoptive T-cell therapy targeting MAGE-A4 achieves responses in patients with multiple solid tumors

Using functional MRI to demonstrate neural suppression in autism

UMSOM scientists develop experimental rapid diagnostic test for COVID-19

Targeted therapy tepotinib shows durable response in NSCLC patients with METex14 skipping mutation

Targeted therapy pralsetinib shows high response rates in patients with RET fusion-positive cancers

Addition of monoclonal antibody to trimodality therapy offers no benefit in HER2 over expressing esophageal cancer

UTHSC researcher awarded NIH grant to study age-related multimorbidity

Study finds nitrous oxide use during labor to be safe with rare side effects

New technology developed to map cholesterol metabolism in the brain

Study analyzes cancer diagnosis in children with birth defects

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

Using gene therapy to help the body to make its own cancer drugs

NIH funding supports research on first therapeutic drug to regenerate heart tissue

A Senator from Arizona emerges as a pharma favorite

As COVID cuts deadly path through Indiana prisons, inmates say symptoms ignored

Changes in gut mucus are linked to brain disorders

Hate unmasked in America

Researchers review all clinical and research findings related to COVID-19

Study shows how toxic protein leads to neuronal death and dementia

Study: Glucocorticoids are harmful for patients suffering from viral respiratory infections

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