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New research points to potential target for treating triple negative breast cancer

New research from the University of Michigan Comprehensive Cancer Center and Georgia Regents University finds that a protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells. This provides a potential target for treating triple negative breast cancer, the most aggressive form of the disease.

17 Feb 2014

Vitamin C may reduce risk of most common type of hemorrhagic stroke, says study

Eating foods that contain vitamin C may reduce your risk of the most common type of hemorrhagic stroke, according to a study released today that will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.

17 Feb 2014

Water samples from the Upper Ganges River shed light on the spread of superbugs

The spread of antibiotic-resistance to one of the most pristine locations in Asia is linked to the annual human pilgrimages to the region, new research has shown.

17 Feb 2014

Research findings may help combat MRSA

A research team from Vanderbilt University Medical Center in Nashville, Tenn., is the first to decipher the 3-D structure of a protein that confers antibiotic resistance from one of the most worrisome disease agents: a strain of bacteria called methicillin-resistant Staphylococcus aureus (MRSA), which can cause skin and other infections. The Vanderbilt team's findings may be an important step in combatting the MRSA public health threat over the next 5 to 10 years.

17 Feb 2014

Researcher reveals the secrets of Francisella tularensis bacterium that causes tularemia

Tularemia, aka "rabbit fever," is endemic in the northeastern United States, and is considered to be a significant risk to biosecurity -- much like anthrax or smallpox -- because it has already been weaponized in various regions of the world.

17 Feb 2014

Resolution of inflammation is altered in Alzheimer's disease

New research from Karolinska Institutet in Sweden shows that the final stage of the normal inflammatory process may be disrupted in patients with Alzheimer's disease.

17 Feb 2014

Research provides new insight into the effect of misfolded proteins in neurodegenerative disorders

Research by the University of Southampton has provided new insight into the consequence of accumulated 'misfolded proteins' in neurodegenerative disorders, such as Prion and Alzheimer's disease.

16 Feb 2014

Final stage of normal inflammatory process may be disrupted in patients with Alzheimer's disease

New research from Karolinska Institutet in Sweden shows that the final stage of the normal inflammatory process may be disrupted in patients with Alzheimer's disease. A study published in the journal Alzheimer's & Dementia shows that levels in the brain and cerebrospinal fluid of the molecules necessary for tissue recovery through the clearance of harmful inflammatory substances are lower than normal in patients with Alzheimer's disease. The study also showed association between the lower levels of these molecules with impaired memory function.

14 Feb 2014

University of Liège joins IMI programme to develop new antibiotics against Gram-negative pathogens

More than 30 European universities and companies, led by GlaxoSmithKline, are joining forces in a six-year programme funded by the Innovative Medicines Initiative (IMI) for the sum of EUR 85 millions with the aim of developing new antibiotics against Gram-negative pathogens.

14 Feb 2014

Elusive progenitor cells that give rise to ILCs identified in fetal liver and bone marrow of mice

The elusive progenitor cells that give rise to innate lymphoid cells-a recently discovered group of infection-fighting white blood cells-have been identified in fetal liver and adult bone marrow of mice, researchers from the University of Chicago report early online in the journal Nature.

14 Feb 2014

Novel method for determining diffusion coefficients of analytes in fluids and equilibrium constants of reactions

How strongly do two dissolved analytes react with each other? Such information is of paramount importance not only in chemistry and molecular biology, but also in medicine or pharmacy, where it is used, i.a., to determine optimal drug doses. A method developed in the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw will allow for determining diffusion coefficients of analytes in fluids and equilibrium constants of reactions - quickly, at low cost, and most importantly: universally.

14 Feb 2014

Study shows how Bcl-2 cancer-related protein signals cancer cells to live longer

A team of researchers from Case Western Reserve School of Medicine has discovered how the cancer-related protein Bcl-2 signals cancer cells to live longer.

14 Feb 2014

TSRI receives $2.3M to study long-term memory deficits that contribute to brain diseases

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $2.3 million from the National Institute of Mental Health to study the processes involved in long-term memory and how deficits in those processes contribute to brain diseases.

14 Feb 2014

Researchers find unique role for p66Shc adaptor protein in regulating glucose and cell growth

A protein that has been known until recently as part of a complex communications network within the cell also plays a direct role in regulating sugar metabolism, according to a new study published on-line in the journal Science Signaling (February 18, 2014).

14 Feb 2014

Two new mechanisms open alternative approaches to antibiotics development

The first mechanism disrupts the arrangement of amino acids required for the cohesion of the protease subunits. As a result the protease breaks into two parts. The second acts directly on the core of the active center.

14 Feb 2014

Researchers discover how beneficial bacteria in guts communicate with own cells

Communication is vital to any successful relationship. Researchers from the Institute of Food Research and the University of East Anglia have discovered how the beneficial bacteria in our guts communicate with our own cells.

14 Feb 2014

Fluidigm acquires DVS Sciences

Fluidigm Corp. today announced it has completed its acquisition of DVS Sciences, Inc. With the closing of the acquisition, Fluidigm adds a high-parameter single-cell protein analysis platform to its industry-leading single-cell genomics platforms to create a comprehensive portfolio of advanced technologies serving the rapidly growing single-cell genomics and proteomics markets.

13 Feb 2014

Prothelia, University of Nevada, Reno and Alexion partner to develop Laminin-111 for MDC1A

Prothelia Incorporated and University of Nevada, Reno announce that they have entered into strategic agreements with Alexion for the development of Laminin-111, a patented experimental protein replacement therapy for merosin-deficient congenital muscular dystrophy (MDC1A), a life-threatening, ultra-rare disease caused by a genetic deficiency of the Laminin-211 protein.

13 Feb 2014

Researchers reveal how genome-editing tool works as 'guided missile' to correct errors in genetic code

Researchers from the Broad Institute and MIT have teamed up with colleagues from the University of Tokyo to form the first high definition picture of the Cas9 complex - a key part of the CRISPR-Cas system used by scientists as a genome-editing tool to silence genes and probe the biology of cells. Their findings, which are reported this week in Cell, are expected to help researchers refine and further engineer the tool to accelerate genomic research and bring the technology closer to use in the treatment of human genetic disease.

13 Feb 2014

Aerpio Therapeutics doses first patient in AKB-9778 Phase 2 trial for diabetic macular edema treatment

Aerpio Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on advancing innovative therapies for vascular diseases, today announced that it has dosed the first patient in a Phase 2 trial evaluating AKB-9778, a Tie2 activator, alone and in combination with ranibizumab (Lucentis) for the treatment of diabetic macular edema (DME). AKB-9778 is a first-in-class inhibitor of human protein tyrosine phosphatase beta (HPTPβ) that activates the Tie2 pathway to promote vascular stability, preventing abnormal blood vessel growth and vascular leak.

13 Feb 2014

G Protein News and Research

New research points to potential target for treating triple negative breast cancer

Vitamin C may reduce risk of most common type of hemorrhagic stroke, says study

Water samples from the Upper Ganges River shed light on the spread of superbugs

Research findings may help combat MRSA

Researcher reveals the secrets of Francisella tularensis bacterium that causes tularemia

Resolution of inflammation is altered in Alzheimer's disease

Research provides new insight into the effect of misfolded proteins in neurodegenerative disorders

Final stage of normal inflammatory process may be disrupted in patients with Alzheimer's disease

University of Liège joins IMI programme to develop new antibiotics against Gram-negative pathogens

Elusive progenitor cells that give rise to ILCs identified in fetal liver and bone marrow of mice

Novel method for determining diffusion coefficients of analytes in fluids and equilibrium constants of reactions

Study shows how Bcl-2 cancer-related protein signals cancer cells to live longer

TSRI receives $2.3M to study long-term memory deficits that contribute to brain diseases

Researchers find unique role for p66Shc adaptor protein in regulating glucose and cell growth

Two new mechanisms open alternative approaches to antibiotics development

Researchers discover how beneficial bacteria in guts communicate with own cells

Fluidigm acquires DVS Sciences

Prothelia, University of Nevada, Reno and Alexion partner to develop Laminin-111 for MDC1A

Researchers reveal how genome-editing tool works as 'guided missile' to correct errors in genetic code

Aerpio Therapeutics doses first patient in AKB-9778 Phase 2 trial for diabetic macular edema treatment

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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