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In super-vaxxed Vermont, covid strikes — but packs far less punch

Even Eden, a snow-covered paradise in northern Vermont, is poisoned by omicron.

28 Jan 2022

Impact of the Omicron variant on disease severity and healthcare utilization

Researchers compare trends in disease and hospital utilization during Omicron circulation to the previous SARS-CoV-2 variants in the U.S.

28 Jan 2022

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

In a new study, researchers conducted activity-based proteomic profiling of patients who had severe SARS-CoV-2 infections to understand the impact of DNA clearance on mortality.

28 Jan 2022

Potential therapy candidates for patients infected with the SARS-CoV-2 Omicron variant

Researcher discusses several promising therapeutic candidates that have been proposed for the treatment of patients infected with the Omicron variant.

28 Jan 2022

Study demonstrates minimally invasive, aerosolized vaccine candidate to combat SARS-CoV-2

This study showed inhalable Covid-19 mimetic particle carriers as potential, versatile, aerosolizable COVID-19 vaccine candidates if worked on with continued optimization and refinement.

28 Jan 2022

Magnetic nanoparticles for SARS-CoV-2 and other virus detection systems

Researchers discuss the contributions that have been provided by magnetic nanoparticles for the molecular diagnosis of human viruses.

28 Jan 2022

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

In a new study, researchers hypothesized and developed broad-spectrum SARS-CoV-2 inhibitors, ReconnAbs, by modifying the existing non-neutralizing antibodies targeted towards the highly conserved epitopes of the SARS-CoV-2 spike (S) protein combined with a receptor-blocking component.

28 Jan 2022

E406W mutation on SARS-CoV-2 RBD escapes monoclonal antibody cocktail-mediated neutralization

Researchers look to better understand the molecular basis of E406W-mediated escape from the REGEN-COV cocktail and cilgavimab.

28 Jan 2022

Intranasal interferon-λ treatment protects mice against SARS-CoV-2 Beta and Omicron variants

Researchers investigate the possible efficacy of IFN-λ in the context of SARS-CoV-2 infection in mice.

28 Jan 2022

Airborne SARS-CoV-2 transmission beyond home isolation rooms may pose infection risk to others

A Rutgers study has detected tiny airborne particles containing RNA from the SARS-CoV-2 that causes COVID-19, both inside and outside of the rooms in which infected people were self-isolating at home. This finding suggests that airborne transmission beyond the isolation rooms in homes may pose a risk of infection to other home occupants.

28 Jan 2022

Pulse oximeters give false readings in a group of patients with COVID-19

The severity of COVID-19 pneumonia can be difficult to assess in people from different ethnic groups, due to inaccurate readings from a device that measures the level of oxygen in the blood of patients.

28 Jan 2022

Exposure to unconventional oil and gas development linked to higher risk of early mortality

Elderly people living near or downwind of unconventional oil and gas development (UOGD)—which involves extraction methods including directional (non-vertical) drilling and hydraulic fracturing, or fracking—are at higher risk of early death compared with elderly individuals who don't live near such operations, according to a large new study from Harvard T.H. Chan School of Public Health.

27 Jan 2022

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

A new study analyzed whether alveolar epithelial cell necrosis at an early stage SARS-CoV-2 infection and subsequent releases of damage-associated molecular patterns could aggravate COVID-19-associated acute respiratory distress syndrome.

27 Jan 2022

Scientists identify immunogens that can elicit antibody responses against multiple SARS-CoV-2 variants

In a new study, researchers identified conserved sites in the SARS-CoV-2 spike protein using structural and sequence data, and then combined the results with existing deep mutational scanning data to design six antigens that can offer protection against significant immune escape mutations in the SARS-CoV-2 receptor-binding domain.

27 Jan 2022

SARS-CoV-2 mutations and their impact on spike protein-specific T lymphocytes

New research assesses the impact of mutations in SARS-CoV-2 variants of concern (VOCs) on the T lymphocytes, specifically to the spike (S) protein of SARS-CoV-2.

27 Jan 2022

Effects of multi-nutrient supplementation on COVID-19 severity in elderly patients

In a new study, researchers analyzed the effects of multi-nutrient supplementation on SARS-CoV-2 vaccine efficacy and the overall improvement of respiratory and muscle function in elderly COVID-19 patients.

27 Jan 2022

Targeting CHI3L1 inhibits SARS-CoV-2 variants, including Delta and Omicron

Researchers show that the CHI3L1 inhibitors reduce epithelial cell infection by SARS-CoV-2 VOC pseudovirus moieties.

27 Jan 2022

Significance of metabolic parameters in COVID-19 prognosis

In a new study, researchers evaluated the significance of metabolic parameters in determining COVID-19 prognosis.

27 Jan 2022

Cedars-Sinai experts conduct a national analysis on COVID-19 lung transplants

The analysis of more than 3,000 lung transplants in the U.S. between Aug. 1, 2020, and Sept. 30, 2021, showed that during the pandemic, 7% of the nation's lung transplants were performed to treat severe, irreversible lung damage caused by COVID-19. More than half of these patients needed ventilators or extracorporeal membrane oxygenation, or ECMO, before their transplant.

27 Jan 2022

Impact of SARS-CoV-2 testing behavior on observational studies of vaccine efficiency

A new study investigated the differences in SARS-CoV-2 testing behavior exhibited by vaccinated and unvaccinated individuals.

27 Jan 2022

Respiratory News and Research

In super-vaxxed Vermont, covid strikes — but packs far less punch

Impact of the Omicron variant on disease severity and healthcare utilization

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

Potential therapy candidates for patients infected with the SARS-CoV-2 Omicron variant

Study demonstrates minimally invasive, aerosolized vaccine candidate to combat SARS-CoV-2

Magnetic nanoparticles for SARS-CoV-2 and other virus detection systems

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

E406W mutation on SARS-CoV-2 RBD escapes monoclonal antibody cocktail-mediated neutralization

Intranasal interferon-λ treatment protects mice against SARS-CoV-2 Beta and Omicron variants

Airborne SARS-CoV-2 transmission beyond home isolation rooms may pose infection risk to others

Pulse oximeters give false readings in a group of patients with COVID-19

Exposure to unconventional oil and gas development linked to higher risk of early mortality

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

Scientists identify immunogens that can elicit antibody responses against multiple SARS-CoV-2 variants

SARS-CoV-2 mutations and their impact on spike protein-specific T lymphocytes

Effects of multi-nutrient supplementation on COVID-19 severity in elderly patients

Targeting CHI3L1 inhibits SARS-CoV-2 variants, including Delta and Omicron

Significance of metabolic parameters in COVID-19 prognosis

Cedars-Sinai experts conduct a national analysis on COVID-19 lung transplants

Impact of SARS-CoV-2 testing behavior on observational studies of vaccine efficiency

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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