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Entasis and GARDP partner to develop oral antibiotic for treatment of drug-resistant gonorrhea

Zoliflodacin, a novel first-in-class oral antibiotic and one of the only treatments in development to address the rapidly-growing threat of drug-resistant gonorrhea will enter pivotal trials, thanks to a new partnership between the not-for-profit Global Antibiotic Research and Development Partnership and Entasis Therapeutics.

7 Jul 2017

New single probe method provides PCR-free detection of microRNA linked to liver toxicity

Quanterix Corporation, a company digitizing biomarker analysis with the goal of advancing the science of precision health, and DestiNA Genomics Ltd, a manufacturer of patented reagents for nucleic acid detection, today announced that PLOS ONE has published a proof-of-concept single probe method for detecting microRNA biomarkers associated with liver toxicity.

6 Jul 2017

Study: Personalized neoantigen vaccine stimulates strong anti-tumor response in melanoma patients

A personal cancer treatment vaccine that targets distinctive "neoantigens" on tumor cells has been shown to stimulate a potent, safe, and highly specific immune anti-tumor response in melanoma patients, report scientists from Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard.

5 Jul 2017

High-throughput screening technique reveals new brain cancer drug targets

Researchers from Case Western Reserve University School of Medicine and The Cleveland Clinic designed a way to screen brain tumor cells and identify potential drug targets missed by other methods.

5 Jul 2017

Wayne State researchers receive NIH grant to mimic benefits of exercise in sedentary patients

A team of researchers led by Robert Wessells, Ph.D., assistant professor of physiology in the School of Medicine at Wayne State University, has received a two-year, $423,500 grant from the National Institute on Aging of the National Institutes of Health for the project, "Octopamine mediates benefits of endurance exercise in Drosophila."

30 Jun 2017

Researchers discover biological link between gut bacteria metabolism and obesity

Cleveland Clinic researchers have uncovered a biological link between gut bacteria metabolism and obesity.

30 Jun 2017

Measuring set of proteins may enable earlier diagnosis of autism spectrum disorder

Measuring a set of proteins in the blood may enable earlier diagnosis of autism spectrum disorder (ASD), according to a study from the Peter O'Donnell Jr. Brain Institute at UT Southwestern Medical Center.

30 Jun 2017

FDA to expedite orphan drug processing queues

In a press release the U.S. Food and Drug Administration (FDA) released a plan for eliminating the backlog regarding orphan drug application status and also released plans for deadlines to clear the queues.

29 Jun 2017

CWRU researcher receives major NIH grants to develop microscopic drug-delivery systems

Nicole F. Steinmetz, PhD, George J. Picha Professor in Biomaterials, member of the Case Comprehensive Cancer Center, and Director of the Center for Bio-Nanotechnology at Case Western Reserve School of Medicine, has received two major grants from the National Institutes of Health to develop microscopic drug-delivery systems for patients living with breast cancer, and patients at risk for serious blood clots.

29 Jun 2017

Simple treatment leads to sustained virological response in patients with thalassaemia and HCV

Many individuals with the blood disorder thalassaemia also carry the hepatitis C virus (HCV) due to contaminated transfusions before 1990.

29 Jun 2017

Adding new antibody to chemotherapy could bolster effects of cancer treatment

Adding an investigational antibody to the chemotherapy rituximab appears to restore its cancer-killing properties in certain leukemia patients with a natural resistance to the drug, according to a small, proof-of-concept study by Duke Cancer Institute researchers.

29 Jun 2017

Injecting plant-based nanoparticles and chemotherapy drug helps halt tumor progression in mice

Researchers from Case Western Reserve University School of Medicine in collaboration with researchers from Dartmouth Geisel School of Medicine and RWTH Aachen University have adapted virus particles- that normally infect potatoes- to serve as cancer drug delivery devices for mice.

28 Jun 2017

Research team receives NIH grant to develop new way to examine cancer cell metastasis

A University of Delaware researcher is part of a team that recently received a grant from the National Institutes of Health to develop a new way to examine how cancer cells metastasize.

28 Jun 2017

Pharmaceutical giant Roche funds concept study aiming to find cure for Angelman syndrome

A collaborative group of parent-driven organizations seeking a cure for Angelman syndrome has teamed up with F. Hoffmann-La Roche Ltd, one of the world’s largest pharmaceutical and diagnostics companies, in the first phase of a study that will support the design of human clinical trials and treatment development for the disorder.

28 Jun 2017

Mouse study uncovers key molecular player in heart enlargement

The heart is a dynamic muscle that grows and shrinks in response to stressors such as exercise and disease. The secret to its malleability lies in individual cells, which get bigger or smaller depending on the heart's needs.

27 Jun 2017

New nanoallergen technology could help provide clear, accurate assessment of peanut allergies

Researchers have developed a novel platform to more accurately detect and identify the presence and severity of peanut allergies, without directly exposing patients to the allergen, according to a new study published in the journal Scientific Reports.

27 Jun 2017

Researchers identify new way to effectively kill cancer stem cells using existing drugs

A team of researchers at McMaster University has identified a unique feature of cancer stem cells that can be exploited to kill the deadly cells thought to be the reason that cancer comes back after therapy.

23 Jun 2017

New biomarker assay improves detection, assessment of neuroblastoma

Investigators at The Saban Research Institute of Children's Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease.

23 Jun 2017

Scientists reveal detailed snapshot of bacterial microcompartment shells

For the first time, scientists have visualized the fine details of bacterial microcompartment shells - the organisms' submicroscopic nanoreactors, which are comprised completely of protein.

22 Jun 2017

Gut bacteria play key role in regulating abdominal pain, mice study finds

Scientists at the Science Foundation Ireland-funded APC Microbiome Institute at University College Cork, Ireland, have shown that, at least in mice, gut bacteria play a key role in regulating abdominal pain and its associated changes in the brain and spinal cord.

21 Jun 2017

Therapeutics News and Research

Entasis and GARDP partner to develop oral antibiotic for treatment of drug-resistant gonorrhea

New single probe method provides PCR-free detection of microRNA linked to liver toxicity

Study: Personalized neoantigen vaccine stimulates strong anti-tumor response in melanoma patients

High-throughput screening technique reveals new brain cancer drug targets

Wayne State researchers receive NIH grant to mimic benefits of exercise in sedentary patients

Researchers discover biological link between gut bacteria metabolism and obesity

Measuring set of proteins may enable earlier diagnosis of autism spectrum disorder

FDA to expedite orphan drug processing queues

CWRU researcher receives major NIH grants to develop microscopic drug-delivery systems

Simple treatment leads to sustained virological response in patients with thalassaemia and HCV

Adding new antibody to chemotherapy could bolster effects of cancer treatment

Injecting plant-based nanoparticles and chemotherapy drug helps halt tumor progression in mice

Research team receives NIH grant to develop new way to examine cancer cell metastasis

Pharmaceutical giant Roche funds concept study aiming to find cure for Angelman syndrome

Mouse study uncovers key molecular player in heart enlargement

New nanoallergen technology could help provide clear, accurate assessment of peanut allergies

Researchers identify new way to effectively kill cancer stem cells using existing drugs

New biomarker assay improves detection, assessment of neuroblastoma

Scientists reveal detailed snapshot of bacterial microcompartment shells

Gut bacteria play key role in regulating abdominal pain, mice study finds

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