Therapeutics News and Research

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Study suggests sons of older fathers have characteristics of ‘geeks’

Sons of older fathers are more intelligent, more focused on their interests, and less concerned about fitting in, all characteristics typically seen in "geeks," according to research conducted at The Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai and published on June 20 in the journal Translational Psychiatry.

21 Jun 2017

Vast numbers of peripheral genes can influence diseases, Stanford researchers suggest

A core assumption in the study of disease-causing genes has been that they are clustered in molecular pathways directly connected to the disease. But work by a group of researchers at the Stanford University School of Medicine suggests otherwise.

20 Jun 2017

Genetic mutation could be cause of severe eczema, research finds

A genetic mutation could be the cause of severe eczema, according to new research published June 19 in Nature Genetics by researchers at the Uniformed Services University of the Health Sciences.

20 Jun 2017

New review finds massive problem of self-medication misuse in the Middle East

A new review indicates that there is a massive problem of self-medication misuse in the Middle East. The findings, which are published in Pharmacology Research & Perspectives, indicate the need for better patient and physician education, as well as improved policies that restrict sales of prescription medications without a prescription.

19 Jun 2017

TSRI scientist and partners receive $7.2 million grant to create new RNA-based treatments for ALS

Professor Matthew Disney of the Department of Chemistry on the Florida campus of The Scripps Research Institute, together with scientists from Mayo Clinic's Florida campus and Johns Hopkins School of Medicine, has been awarded $7.2 million from the National Institute of Neurological Disorders and Stroke of The National Institutes of Health to create new RNA-based treatments for the most common form of amyotrophic lateral sclerosis (ALS), as well as a type of frontotemporal dementia (FTD).

15 Jun 2017

Study finds that molecular decoy can target and reduce UTI-causing bacteria in the gut

Urinary tract infections (UTIs) are among the most common infections, and they tend to come back again and again, even when treated. Most UTIs are caused by E. coli that live in the gut and spread to the urinary tract.

15 Jun 2017

Experimental drug suppresses new defective PTEN cancer pathway, study finds

A collaboration between Saïd M. Sebti, Ph.D., chair of Moffitt Cancer Center's Drug Discovery Department, and Michele Pagano, M.D., chair of the Department of Biochemistry and Molecular Pharmacology at New York University's Langone Medical Center, led to the publication of an important study in the latest issue of Nature.

14 Jun 2017

USC scientists illuminate impact of early brain-clogging plaques on Alzheimer's disease

Older adults with elevated levels of brain-clogging plaques -- but otherwise normal cognition -- experience faster mental decline suggestive of Alzheimer's disease, according to a new study led by the Keck School of Medicine of USC that looked at 10 years of data.

13 Jun 2017

Impairment of specific gene increases susceptibility to opioid addiction and binge eating, study shows

Impairment of a particular gene raises increases susceptibility to opioid addiction liability as well as vulnerability to binge eating according to a new study.

13 Jun 2017

Antibody-based theranostic agent shows promise for identifying and treating pancreatic tumors

Pancreatic cancer is associated with bleak five-year survival rates and limited treatment options, but new research is offering hope.

13 Jun 2017

Melbourne study offers hope for better lung cancer treatment

A Melbourne study is set to improve treatment options for patients with the second most common type of lung cancer, lung squamous cell carcinoma, a disease for which new anti-cancer drugs are urgently needed.

13 Jun 2017

UNC researchers evaluate investigational medication for treatment of postpartum depression

Researchers at the University of North Carolina School of Medicine announced the publication of results from a multi-site phase 2 clinical trial with brexanolone, an investigational medication, in the treatment of severe postpartum depression.

13 Jun 2017

Review suggests need for improved treatment outcome measures in clinical trials for FXS

A group of researchers from several institutions in the USA, including Johns Hopkins Medicine, reports that its review of 22 clinical trials of fragile X syndrome (FXS) suggests the need for a wider use of newer and improved treatment outcome measurement tools for this and other several neurodevelopmental disorders.

13 Jun 2017

Moffitt researchers develop novel drug that may help combat castration-resistant prostate cancer

Prostate cancer is the third most common cause of cancer-related death in men in the United States. It is estimated that 161,360 men will be diagnosed and more than 26,700 men will die from the disease in this year.

12 Jun 2017

Type 2 diabetes incidence among youth increases in direct proportion with severity of obesity

The risk of developing type 2 diabetes (T2D) by age 20 was 12 times as high in severely obese American Indian children 5 to 9 years of age as in normal-weight youth in that age range, according to a study titled "Long-term Risk of Type 2 Diabetes in Youth with Increasing Severity of Obesity," presented today at the American Diabetes Association's 77th Scientific Sessions at the San Diego Convention Center.

12 Jun 2017

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

In an expanded, three-year clinical trial of 86 patients with colorectal and 11 other kinds of cancer that have so-called 'mismatch repair' genetic defects, scientists at Johns Hopkins Medicine and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have found that half of the patients respond to an immunotherapy drug called pembrolizumab.

9 Jun 2017

Joslin Diabetes Center researchers establish CCTD to develop and translate cell-based interventions

Researchers and clinicians at Joslin Diabetes Center have established a Center for Cell-Based Therapy for Diabetes, the goal of which is to lead the development and translation of cell-based interventions to treat and cure diabetes and its complications.

9 Jun 2017

Removal of senescent cells could delay onset of age-related pathologies

A recent study, led by an international team of researchers confirms that targeted removal of senescent cells (SnCs), accumulated in many vertebrate tissues as we age, contribute significantly in delaying the onset of age-related pathologies.

9 Jun 2017

Activating bitter taste receptors can stop unwanted contractions that occur during preterm labor

This could be good news for those trying to prevent preterm labor: New research published online in The FASEB Journal suggests that exposing bitter taste receptors in the uterus to certain substances can stop many unwanted contractions that occur during premature labor.

8 Jun 2017

People who exercise excessively may be prone to gut issues

A review of published studies has found that people who exercise excessively may be prone to acute or chronic gut issues.

7 Jun 2017

Therapeutics News and Research

Study suggests sons of older fathers have characteristics of ‘geeks’

Vast numbers of peripheral genes can influence diseases, Stanford researchers suggest

Genetic mutation could be cause of severe eczema, research finds

New review finds massive problem of self-medication misuse in the Middle East

TSRI scientist and partners receive $7.2 million grant to create new RNA-based treatments for ALS

Study finds that molecular decoy can target and reduce UTI-causing bacteria in the gut

Experimental drug suppresses new defective PTEN cancer pathway, study finds

USC scientists illuminate impact of early brain-clogging plaques on Alzheimer's disease

Impairment of specific gene increases susceptibility to opioid addiction and binge eating, study shows

Antibody-based theranostic agent shows promise for identifying and treating pancreatic tumors

Melbourne study offers hope for better lung cancer treatment

UNC researchers evaluate investigational medication for treatment of postpartum depression

Review suggests need for improved treatment outcome measures in clinical trials for FXS

Moffitt researchers develop novel drug that may help combat castration-resistant prostate cancer

Type 2 diabetes incidence among youth increases in direct proportion with severity of obesity

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

Joslin Diabetes Center researchers establish CCTD to develop and translate cell-based interventions

Removal of senescent cells could delay onset of age-related pathologies

Activating bitter taste receptors can stop unwanted contractions that occur during preterm labor

People who exercise excessively may be prone to gut issues

Advancing therapeutic biopolymer development eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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