Clinical Trial News and Research

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Shorter treatment for Chagas disease found to be effective and safer than standard treatment

A two-week treatment course for adult patients with chronic Chagas disease showed, when compared to placebo, similar efficacy and significantly fewer side effects than the standard treatment duration of eight weeks, according to the results of a clinical trial in Bolivia led by the Drugs for Neglected Diseases initiative.

14 Mar 2019

Statins protect against brain hemorrhages

The drugs statins, which are used to prevent cardiovascular diseases, also guard against brain hemorrhages. This is the conclusion of most extensive study ever carried out, which thus also rebuffs suspicions of the opposite being true.

14 Mar 2019

Molecular patterns could help predict relapse risk in breast cancer patients

The genetic and molecular make-up of individual breast tumors holds clues to how a woman’s disease could progress, including the likelihood of it coming back after treatment, and in what time frame, according to a Cancer Research UK-funded study published in Nature today (Wednesday).

14 Mar 2019

Preclinical data shows combination immunotherapy could suppress tumor growth in the liver

Even as overall cancer incidence and mortality decrease in the United States, the number of people diagnosed with liver cancer is on the rise.

14 Mar 2019

Drug that prevents respiratory ailments in preemies reduces healthcare costs

A new study from researchers at Columbia University Vagelos College of Physicians and Surgeons shows that a drug given to some pregnant women to prevent severe respiratory ailments in preterm newborns reduces healthcare costs.

14 Mar 2019

PNAS publishes results of pilot study for early detection of liver cancer

Today, Proceedings of the National Academy of Sciences published the results of a pilot study for early detection of liver cancer in a cohort of HBV carriers, who are at risk for developing this disease.

13 Mar 2019

“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery

Richard Eglen discusses the use of organoids in drug discovery, including the screening of candidate compounds for efficacy, toxicity, and pharmacokinetics.

From Corning Life Sciences 13 Mar 2019

Proteins linked with diabetic complications and heart disease in diabetic patients identified

Protein pathways that are closely linked to changes in both triglyceride and hemoglobin A1c levels in diabetic patients have been identified in new research by the Intermountain Medical Center Heart Institute in Salt Lake City.

13 Mar 2019

Access to real-time genotype data influences prescriber behavior after PCI

Today, in a late-breaking featured clinical research session at the American College of Cardiology Scientific Sessions 2018, researchers from Penn Medicine present first-of-its-kind data on the impact of real-time CYP2C19 genotype results when prescribing antiplatelet drugs in the clinic.

13 Mar 2019

Study unravels how cancer medication works in brains of Parkinson's patients

Laboratory analysis from the first arm of a phase II clinical trial testing the use of nilotinib in patients with Parkinson's disease demonstrates precisely how the agent increases levels of dopamine in the brains of study participants, says a research team at Georgetown University Medical Center. Symptoms of Parkinson's, such as motor dysfunction, are a result of a dopamine loss.

13 Mar 2019

New data describes way to reliably quantify a person's 'immune age'

New data, published in Nature Medicine, from scientists at the Technion, Stanford and CytoReason describes for the first time ever a way to reliably quantify a person's "immune age".

12 Mar 2019

Precision cancer drugs spark powerful immune response and boost effects of immunotherapy

Precision cancer drugs called PARP inhibitors have a previously unknown ability to boost the immune system, and could help many more patients benefit from immunotherapy, a new study reveals.

11 Mar 2019

Study finds high rate of viral suppression among people new to HIV care

Eighty-six percent of individuals who entered HIV care soon after diagnosis maintained viral suppression after 48 weeks during a clinical trial conducted at four National Institutes of Health-funded Centers for AIDS Research across the United States.

9 Mar 2019

Novel drug shows potential to prevent sepsis progression

Research into a new breakthrough therapy in the fight against sepsis has shown that the drug has potential to stop all sepsis-causing bacteria from triggering organ damage in the early stages of the condition.

8 Mar 2019

Northwestern Medicine and Eko join hands to improve heart disease screening with AI technology

Northwestern Medicine Bluhm Cardiovascular Institute is pioneering the use of artificial intelligence for cardiac screening in a new study of Eko's cardiac monitoring platform.

8 Mar 2019

Researchers develop new method to boost efficiency of CRISPR gene editing in DMD

Scientists have developed a method to boost the efficiency of CRISPR gene editing in Duchenne muscular dystrophy (DMD), according to a study that could have implications for optimizing gene therapies for other diseases.

7 Mar 2019

Fasting-mimicking diet changes gut microbiota to reduce IBD pathology in mice

Dietary modifications are frequently used to treat inflammatory bowel diseases.

6 Mar 2019

Patients experiment with prescription drugs to fight aging

Dr. Alan Green's patients travel from around the country to his tiny practice in Queens, N.Y., lured by the prospect of longer lives.

6 Mar 2019

Integrated therapy is effective in treating obesity and depression

An intervention combining behavioral weight loss treatment and problem-solving therapy with as-needed antidepressant medication for participants with co-occurring obesity and depression improved weight loss and depressive symptoms compared with routine physician care, according to an article published in the Journal of the American Medical Association.

6 Mar 2019

Researchers harness power of artificial intelligence to better match cancer patients with clinical trials

A team of researchers from the Department of Energy's Oak Ridge National Laboratory Health Data Sciences Institute have harnessed the power of artificial intelligence to better match cancer patients with clinical trials.

6 Mar 2019

Clinical Trial News and Research

Shorter treatment for Chagas disease found to be effective and safer than standard treatment

Statins protect against brain hemorrhages

Molecular patterns could help predict relapse risk in breast cancer patients

Preclinical data shows combination immunotherapy could suppress tumor growth in the liver

Drug that prevents respiratory ailments in preemies reduces healthcare costs

PNAS publishes results of pilot study for early detection of liver cancer

“Fail Fast, But More Confidently”: Developing Organoids for Drug Development and Discovery

Proteins linked with diabetic complications and heart disease in diabetic patients identified

Access to real-time genotype data influences prescriber behavior after PCI

Study unravels how cancer medication works in brains of Parkinson's patients

New data describes way to reliably quantify a person's 'immune age'

Precision cancer drugs spark powerful immune response and boost effects of immunotherapy

Study finds high rate of viral suppression among people new to HIV care

Novel drug shows potential to prevent sepsis progression

Northwestern Medicine and Eko join hands to improve heart disease screening with AI technology

Researchers develop new method to boost efficiency of CRISPR gene editing in DMD

Fasting-mimicking diet changes gut microbiota to reduce IBD pathology in mice

Patients experiment with prescription drugs to fight aging

Integrated therapy is effective in treating obesity and depression

Researchers harness power of artificial intelligence to better match cancer patients with clinical trials

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