Transplant News and Research

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Over 60's do well after liver transplantation

Patients who undergo liver transplantation at age 60 or above have 1-year and 5-year survival rates similar to those of younger patients and they experience fewer episodes of rejection.

3 Oct 2007

Fetal cell transplant could be a hidden link between childbirth and reduced risk of breast cancer

Some benefits of motherhood are intangible, but one has been validated through biostatistical research: women who bear children have a reduced risk of developing breast cancer.

3 Oct 2007

Fetal cell "transplant" could be a hidden link between childbirth and reduced risk of breast cancer

Some benefits of motherhood are intangible, but one has been validated through biostatistical research: women who bear children have a reduced risk of developing breast cancer.

2 Oct 2007

Better use of kidneys from deceased donors

Several new studies suggest how transplant surgeons can make more effective use of kidneys from deceased donors – even those that are at the outer limits of acceptance criteria – according to researchers from Wake Forest University Baptist Medical Center.

2 Oct 2007

Researchers uncover likely source of rejection for otherwise well-matched kidney transplants

UT Southwestern Medical Center researchers, collaborating with colleagues in Germany, have for the first time identified antibodies associated with transplant rejection of otherwise healthy kidneys.

27 Sep 2007

UCLA Medical Center performs its first living donor kidney swap

UCLA Medical Center on Sept. 20 performed its first living donor kidney “swap,” a procedure in which a loved one of a kidney transplant patient who is not compatible as a donor exchanges organs with another incompatible pair under an innovative new paired donation program.

27 Sep 2007

Study of bone marrow stem cells in multiple sclerosis

A new pilot clinical trial to test bone marrow stem cell therapy with a small group of patients with multiple sclerosis has started at Frenchay Hospital.

27 Sep 2007

Hydrogen sulfide based drug shows promise in reducing heart-attack damage

Producing a state of "hibernation on demand" in mice by administering an experimental drug from Ikaria (an injectable formulation of the biological gas hydrogen sulfide) showed promise in a study designed to reduce damage from heart attacks.

26 Sep 2007

Manipulating immune response provides new approach to liver failure

If the results of the animal study can be applied in human patients, the approach may be able to keep patients alive until donor organs become available or to support liver function until the organ can regenerate itself, eliminating the need for a transplant.

25 Sep 2007

Brugia malayi's secrets revealed

An international team of researchers has revealed the genetic secrets of one of the world's most debilitating human parasites, Brugia malayi (B. malayi), which the World Health Organization estimates has seriously incapacitated and disfigured more than 40 million people around the globe.

21 Sep 2007

Scientists solve genetic code of parasitic worm that causes elephantiasis

More than 150 million people worldwide are infected with filarial parasites -- long, thread-like worms that can live for years inside the human body and cause severe, debilitating diseases such as elephantiasis.

21 Sep 2007

Testes offer a promising new source of stem cells

After a decade of research, Howard Hughes Medical Institute scientists have succeeded in reprogramming adult stem cells from the testes of male mice into functional blood vessels and contractile cardiac tissue.

20 Sep 2007

Hydrogen sulfide limits severe heart attack damage

Administering hydrogen sulfide (H2S) directly into the heart during a simulated heart attack significantly reduces the tissue and cell damage often seen in oxygen-starved organs, according to a new study from researchers at the University of Alabama at Birmingham

20 Sep 2007

Re-engineered human T cells effectively target and kill cancerous B cells

Human white blood cells, engineered to recognize other malignant immune cells, could provide a novel therapy for patients with highly lethal B cell cancers such as acute lymphoblastic leukemia (ALL), according to researchers at Memorial Sloan-Kettering Cancer Center (MSKCC).

18 Sep 2007

Sexual function affected by stem cell transplant according to long-term study

A long-term study found that a type of stem cell transplant used for patients with life-threatening diseases, such as leukemia and lymphoma, results in decreased sexual function and activity for recipients.

18 Sep 2007

Gene profiling can single out the worst cases of multiple myeloma and guide therapy

Multiple myeloma patients vary widely in how they respond to treatment, but now researchers at the Myeloma Institute for Research and Therapy at the University of Arkansas for Medical Sciences have identified a small subset of genes whose activity could predict high-risk cases and potentially guide therapy in the future.

18 Sep 2007

Chronic infection persists by targeting stromal cell network in lymphoid organs

One of the biggest challenges to treating infectious diseases and developing preventive vaccines is the ability of many chronic infections to suppress the immune T-cell response over time.

18 Sep 2007

Organ transplantation for HIV-positive patients

Not long ago, organ transplantation was not considered an option for HIV infected patients.

17 Sep 2007

Dendritic cells turn T cells into T regs

Regulatory T cells (also known as T regs) suppress some of the immune system's more inappropriate responses, preventing it from attacking the body's own tissues and stifling its activity once invading microbes have been fought off.

17 Sep 2007

New devices and trials for the treatment and prevention of dialysis access stenosis

Having a healthy kidney is worth a billion dollars. But an unhealthy kidney costs more - about $16 billion more, according to Prabir Roy-Chaudhury, MD, PhD, associate professor in the division of nephrology and hypertension at the University of Cincinnati (UC).

13 Sep 2007