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SARS-CoV-2 antibody levels and types differ by disease severity, study finds

Researchers have measured the antibody levels and types in hospitalized coronavirus disease 2019 (COVID-19) patients with different disease severity. Their results suggest gut immune pathways could play a role in reducing virus-based inflammation and recovery.

22 Dec 2020

Trinity team uncovers mutations linked with early onset dementia

Scientists at Trinity College Dublin today announced a significant advance in our understanding of an early onset form of dementia that may also progress our understanding of conditions such as Alzheimer's disease.

22 Dec 2020

Scientists isolate anti-COVID-19 nanobodies produced by a llama

National Institutes of Health researchers have isolated a set of promising, tiny antibodies, or "nanobodies," against SARS-CoV-2 that were produced by a llama named Cormac.

22 Dec 2020

Study reveals how the immune system detects signs of disease, activates a protective response

Researchers at the Francis Crick Institute have uncovered an important process in how our immune system detects signs of disease and activates a protective response. This understanding could improve efforts to find new and effective immunotherapy treatments for diseases like cancer.

22 Dec 2020

Researchers detect novel IRAK4 mutations in infant with encephalitis and HHV6 reactivation

An infant's odd case of rare encephalitis not typically found in children led researchers to discover never before seen genetic mutations and a more accurate technique to examine the IRAK4 gene responsible for innate immunity.

22 Dec 2020

Researchers have a promising lead on COVID-19 treatment

By taking a lesson from prostate cancer, researchers now have a promising lead on treatment for COVID-19. Two proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, M.D., Ph.D. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers. They also knew that TMPRSS2 was regulated by the androgen receptor.

21 Dec 2020

Absence of anti-tumor protein may cause resistance to EGFR-targeting therapies

The absence of a protein that works to prevent tumor formation may explain why some patients are resistant to a common cancer therapy, according to Penn State College of Medicine researchers.

21 Dec 2020

Sex-specific difference could prevent Alzheimer's treatment from working in females

A University of Ottawa study has found a specific Alzheimer's treatment is effective in male and not female mice, providing a window into the biology of the disease and the effectiveness of targeted treatments.

21 Dec 2020

COVID-19: Meta-analysis unveils adversely affected biological processes in infected lung cells

The researchers Wasco Wruck and Prof. James Adjaye from the Institute of Stem Cell Research and Regenerative Medicine, Medical Faculty of Heinrich-Heine-University Duesseldorf, Germany, employed a bioinformatic approach on transcriptome data pertaining to human lung epithelial cells infected with SARS-CoV-2.

21 Dec 2020

Prior use of renin-angiotensin system inhibitors linked to reduced risk of death in older COVID-19 patients with hypertension

A new study, appearing as a preprint on the medRxiv* server, demonstrates the protective effect of drugs in older COVID-19 patients with hypertension.

21 Dec 2020

SARS-CoV-2 spike protein remains remarkably conserved among 37 variants from Hong Kong

As the coronavirus disease 2019 (COVID-19) pandemic continues to intensify in many parts of the world, vaccine development is proceeding apace.

21 Dec 2020

Cross-reactive coronavirus antibodies shape COVID-19 convalescent plasma functionality

The onset of the current COVID-19 pandemic revealed the seventh known pathogenic human coronavirus, SARS-CoV-2.

21 Dec 2020

Researchers identify novel mechanism by which CREB3L3 protein protects against atherosclerosis

Researchers from the University of Tsukuba identify a novel mechanism by which the protein CREB3L3 protects against atherosclerosis.

21 Dec 2020

Researchers discover more accurate technique to study gene responsible for innate immunity

20 Dec 2020

FDA approves first adjuvant treatment for patients with non-small cell lung cancer

Today, the U.S. Food and Drug Administration approved Tagrisso (osimertinib) as the first adjuvant treatment for patients with non-small cell lung cancer whose tumors have a specific type of genetic mutation.

18 Dec 2020

Study finds how macrophages may contribute to a therapeutic weak spot in breast cancer

Breast cancer, the second most common cancer in the United States, can result from a number of cellular misregulations, such as deficiencies in the DNA-repairing breast cancer gene, BRCA.

18 Dec 2020

Rapid point-of-care lateral flow assay to assess the neutralizing activity of plasma against SARS-CoV-2

A new paper describes the development and validation of a rapid test to measure the neutralizing activity of serum against COVID-19 using a drop of blood.

18 Dec 2020

A protein may be responsible for triggering lung scarring in scleroderma patients

Systemic sclerosis is an autoimmune disease associated with inflammation and fibrosis, or scarring, that affects organs including the skin, heart, kidney and lungs.

17 Dec 2020

Study highlights how the sex differences in COVID-19 are linked to ACE2 protein

Female COVID-19 patients face less severe disease complications and a lower risk of dying than male patients thanks to hormones and chromosomes that contribute to a stronger immune response, according to new research from a University of Alberta-led team.

17 Dec 2020

PVP at Boston Children's awarded $1 million to extend research into adjuvant-based vaccines

For a vaccine to be most effective, sometimes nature needs a little 'extra' something. That something is often an adjuvant -- small molecules added to a vaccine that boost the body's immune response.

17 Dec 2020

Receptor News and Research

SARS-CoV-2 antibody levels and types differ by disease severity, study finds

Trinity team uncovers mutations linked with early onset dementia

Scientists isolate anti-COVID-19 nanobodies produced by a llama

Study reveals how the immune system detects signs of disease, activates a protective response

Researchers detect novel IRAK4 mutations in infant with encephalitis and HHV6 reactivation

Researchers have a promising lead on COVID-19 treatment

Absence of anti-tumor protein may cause resistance to EGFR-targeting therapies

Sex-specific difference could prevent Alzheimer's treatment from working in females

COVID-19: Meta-analysis unveils adversely affected biological processes in infected lung cells

Prior use of renin-angiotensin system inhibitors linked to reduced risk of death in older COVID-19 patients with hypertension

SARS-CoV-2 spike protein remains remarkably conserved among 37 variants from Hong Kong

Cross-reactive coronavirus antibodies shape COVID-19 convalescent plasma functionality

Researchers identify novel mechanism by which CREB3L3 protein protects against atherosclerosis

Researchers discover more accurate technique to study gene responsible for innate immunity

FDA approves first adjuvant treatment for patients with non-small cell lung cancer

Study finds how macrophages may contribute to a therapeutic weak spot in breast cancer

Rapid point-of-care lateral flow assay to assess the neutralizing activity of plasma against SARS-CoV-2

A protein may be responsible for triggering lung scarring in scleroderma patients

Study highlights how the sex differences in COVID-19 are linked to ACE2 protein

PVP at Boston Children's awarded $1 million to extend research into adjuvant-based vaccines

Industry Focus eBook - Cell biology (5th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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