Therapeutics News and Research

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Study provides evidence for antidepressant effects of ketamine

Better known as an anesthetic or as an illicit hallucinogenic drug, ketamine has also long been noted for alleviating depression. But ketamine has not been tested in a large clinical trial, and all evidence of its antidepressant effects has come from anecdotes and small studies of fewer than 100 patients.

3 May 2017

Shire and Parion Sciences to collaborate on P-321 for ophthalmic indications

Shire plc and Parion Sciences, Inc. have announced they have entered into an agreement granting Shire exclusive worldwide rights to develop and commercialize P-321. Shire will lead development of P-321, an investigational epithelial sodium channel (ENaC) inhibitor for the potential treatment of dry eye disease in adults, with the opportunity for Parion to co-fund.

3 May 2017

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Surgery and radiation remove, kill, or damage cancer cells in a certain area. But chemotherapy -- which uses medicines or drugs to treat cancer -- can work throughout the whole body, killing cancer cells that have spread far from the original tumor.

2 May 2017

Penn study sheds new light on mysterious powers of spider silk genes

They can be stronger than steel at a mere fraction of weight, and also can be tougher and more flexible. Spider silks also tend not to provoke the human immune system. Some even inhibit bacteria and fungi, making them potentially ideal for surgery and medical device applications.

2 May 2017

Paternal age at conception may affect social skills of children, study suggests

The age of the father at the time his children are born may influence their social development, suggests a study published in the May 2017 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.

1 May 2017

Noninvasive PET imaging may predict cancer patients’ immunotherapy response early

A noninvasive PET imaging method that measures granzyme B, a protein released by immune cells to kill cancer cells, was able to distinguish mouse and human tumors that responded to immune checkpoint inhibitors from those that did not respond early in the course of treatment.

1 May 2017

Study: Artificial pancreas helps young children better control their diabetes

A pilot study among young children with Type 1 diabetes found that a University of Virginia-developed artificial pancreas helped study participants better control their condition.

28 Apr 2017

Scientists rewire mouse stem cells to fight inflammation caused by arthritis

Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic conditions.

28 Apr 2017

Glycated CD59 identified as novel biomarker for screening and diagnosis of gestational diabetes

Mellitus, LLC today reported the publication of results from a prospective, investigator-initiated study conducted at Brigham and Women's Hospital demonstrating the potential clinical utility of glycated CD59 (GCD59) as a novel biomarker for the screening and diagnosis of gestational diabetes mellitus.

28 Apr 2017

Scientists use rooster testes to shed light on how germ cells fight viruses

Our bodies are constantly under siege by foreign invaders; viruses, bacteria and parasites that want to infiltrate our cells.

27 Apr 2017

Antidepressant improves drug delivery across the blood-brain barrier, rat study shows

NIH rat study suggests amitriptyline temporarily inhibits the blood-brain barrier, allowing drugs to enter the brain.

27 Apr 2017

Unstable chromosomes in lung tumors increase risk of cancer relapse, study reveals

The New England Journal of Medicine and Nature has published the first findings from the Cancer Research UK-funded Tracking Cancer Evolution through Treatment (Rx), TRACERx, lung cancer study, which reveals the increase in the risk of cancer relapse when lung tumors have unstable chromosomes.

27 Apr 2017

Removing senescent cells from joints could reverse progression of osteoarthritis

In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.

26 Apr 2017

Person's brain age could help identify risk of functional decline and mortality

Some elderly people's brains appear older than the age on their birth certificates. These people have a higher risk of developing deteriorating age-associated conditions and impairments, and even of experiencing an earlier death than expected.

25 Apr 2017

Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Imagine this scenario on a highway: A driver starts to make a sudden lane change but realizes his mistake and quickly veers back, too late. Other motorists have already reacted and, in some cases, collide. Meanwhile, the original motorist - the one who caused the problem - drives on.

25 Apr 2017

MedCision and TrakCel to present clinical cell thawing technologies at ISCT

MedCision, LLC, world leader in the automation of pre-clinical and clinical cell thawing, today announced the company’s participation in the 2017 International Society for Cellular Therapy (ISCT) Annual Meeting.

25 Apr 2017

Scientists create new technique for studying how chlamydia interacts with immune system

Scientists at the Wellcome Trust Sanger Institute and their collaborators at the University of British Columbia have created an innovative technique for studying how chlamydia interacts with the human immune system.

25 Apr 2017

Genetic factors may increase person's risk for adverse effects of synthetic cannabinoids

Synthetic cannabinoid abuse is a growing problem in the United States, with new versions of the drugs coming on the market every year. New research is examining how the body processes these man-made drugs and the role that genetics might play in their metabolism.

25 Apr 2017

Engineered nanosponges can reduce severity of infections caused by group A Streptococcus

In a new study, researchers show that engineered nanosponges that are encapsulated in the membranes of red blood cells can reduce the severity of infections caused by group A Streptococcus, the bacteria responsible for strep throat and life-threatening infections such as necrotizing fasciitis, or flesh-eating disease.

25 Apr 2017

Scientists use stem cells to identify underlying cellular defects that cause Angelman syndrome

Researchers at UConn Health used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder, an important step in the ongoing search for potential treatments for Angelman and a possible cure.

25 Apr 2017

Therapeutics News and Research

Study provides evidence for antidepressant effects of ketamine

Shire and Parion Sciences to collaborate on P-321 for ophthalmic indications

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Penn study sheds new light on mysterious powers of spider silk genes

Paternal age at conception may affect social skills of children, study suggests

Noninvasive PET imaging may predict cancer patients’ immunotherapy response early

Study: Artificial pancreas helps young children better control their diabetes

Scientists rewire mouse stem cells to fight inflammation caused by arthritis

Glycated CD59 identified as novel biomarker for screening and diagnosis of gestational diabetes

Scientists use rooster testes to shed light on how germ cells fight viruses

Antidepressant improves drug delivery across the blood-brain barrier, rat study shows

Unstable chromosomes in lung tumors increase risk of cancer relapse, study reveals

Removing senescent cells from joints could reverse progression of osteoarthritis

Person's brain age could help identify risk of functional decline and mortality

Research shows how TET2 protein loss can open door for mutations that drive blood cancers

MedCision and TrakCel to present clinical cell thawing technologies at ISCT

Scientists create new technique for studying how chlamydia interacts with immune system

Genetic factors may increase person's risk for adverse effects of synthetic cannabinoids

Engineered nanosponges can reduce severity of infections caused by group A Streptococcus

Scientists use stem cells to identify underlying cellular defects that cause Angelman syndrome

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Bringing real-time analytics to downstream bioprocess monitoring

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Evaluating new approaches for rare disease genomics

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