Protein C News and Research

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Research provides a comprehensive structural framework to design safer pain-relieving drugs

In the continuing effort to improve upon opioid pain relievers, American and Chinese scientists used cryoEM technology to solve the detailed structures of the entire family of opioid receptors bound to their naturally occurring peptides.

18 Jan 2023

Immunological interactions between asthma, obesity, and the microbiota

This study summarizes the mechanisms associated with obesity-aggravated asthma.

18 Jan 2023

Genotyping technology may help increase the number of kidney transplantations and reduce wait times

ABO blood-type compatibility between organ donors and recipients is crucial for safe transplantations. Across the different ABO blood groups, longer wait-times for a kidney transplant are often experienced by patients who have type B blood because it is a less common ABO blood type, resulting in fewer donors.

18 Jan 2023

Epitope mapping reveals the humoral responses against the main SARS-CoV-2 structural proteins in infected patients from Africa

Researchers performed immunoglobulin (Ig)M and IgG epitope mapping against 487 SARS-CoV-2 peptides.

18 Jan 2023

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board (DSMB) has determined.

18 Jan 2023

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Researchers explored ways galectins can impact immunity and discussed the opportunities and challenges in the field.

18 Jan 2023

Combination of multiple maps uncovers new genetic risk factor for AMD

Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17th in the open access journal PLOS Biology by Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues.

18 Jan 2023

What factors are associated with successful dietary weight loss interventions?

A new study explored the factors governing the success of long- and short-term weight loss interventions.

18 Jan 2023

Researchers explore the mechanism involved in the living world’s fastest cell movements

Raphidocystis contractilis belongs to Heliozoa, a group of eukaryotes commonly found in fresh, brackish, and sea water.

18 Jan 2023

Upregulation of Robo4 expression reduces mortality from severe infection

The researchers screened a library of drugs using a mouse endothelial cell line to identify pathways that are involved in the regulation of Robo4 and found that two competitive SMAD signaling pathways appear to regulate Robo4 expression.

18 Jan 2023

The "Great Escape" by SARS-CoV-2 XBB.1

In a recent article published in the Lancet Microbe, researchers in the Netherlands and the United Kingdom quantified the antigenic diversity of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subvariants, BQ.1.1, BM.1.1.1, and XBB.1, all derivatives of the variant of concern (VOC) Omicron, which emerged in late 2022.

17 Jan 2023

Researchers develop long lasting surface spray with potential to kill viruses and bacteria

University of Queensland researchers have developed a long lasting surface spray that has the potential to kill viruses such as COVID-19 and potentially deadly bacteria.

17 Jan 2023

Future COVID-19 control will require vaccines that induce better mucosal immunity

In a recent study posted to the medRxiv* preprint server, researchers in France explored the relationship between long-term immunoglobulin (Ig)-A response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and taste and smell disorders.

17 Jan 2023

On four flights out of China in December, 22% of passengers were SARS-CoV-2 positive

Researchers document COVID-19 screening results in Italy of 556 flight passengers from two Chinese provinces in late December 2022.

17 Jan 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

Exploring bioinformatics approach for evaluating binding affinities of probable COVID-19 therapeutic decoys

Researchers developed a computational workflow based on molecular dynamic (MD) simulations and artificial neural network (ANN) to assess the SARS-CoV-2 spike (S) protein receptor-binding domain (RBD)-human angiotensin-converting enzyme 2 (hACE2) binding affinities of SARS-CoV-2 variants.

17 Jan 2023

New Pyk2-derived peptide inhibits breast cancer metastasis

An estimated ninety percent of deaths from breast cancer are due to complications resulting from metastasis, a process in which cancer cells break away from where they first formed, travel through the blood or lymph circulatory system, and form new, metastatic tumors in other parts of the body.

17 Jan 2023

Study shows the modulatory effect of resistance training on the endoplasmic reticulum in older adults

Aging involves a balance between oxidants and antioxidants, low-grade inflammation and a protein response that occurs at the cellular level, which is responsible for many health disorders.

17 Jan 2023

S. aureus enhances replication of SARS-CoV-2 in vitro through the bacterial iron-regulated surface determinant protein A

Researchers assessed the impact of Staphylococcus aureus (S. aureus) on SARS-CoV-2 replication.

17 Jan 2023

Could drinking tea help manage COVID-19?

Researchers summarized the content of active ingredients in different types of tea, the second most consumed beverage in the world. They also explored the possibility of using tea extracts for coronavirus disease 2019 (COVID-19) prevention and treatment.

17 Jan 2023

Protein C News and Research

Research provides a comprehensive structural framework to design safer pain-relieving drugs

Immunological interactions between asthma, obesity, and the microbiota

Genotyping technology may help increase the number of kidney transplantations and reduce wait times

Epitope mapping reveals the humoral responses against the main SARS-CoV-2 structural proteins in infected patients from Africa

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Combination of multiple maps uncovers new genetic risk factor for AMD

What factors are associated with successful dietary weight loss interventions?

Researchers explore the mechanism involved in the living world’s fastest cell movements

Upregulation of Robo4 expression reduces mortality from severe infection

The "Great Escape" by SARS-CoV-2 XBB.1

Researchers develop long lasting surface spray with potential to kill viruses and bacteria

Future COVID-19 control will require vaccines that induce better mucosal immunity

On four flights out of China in December, 22% of passengers were SARS-CoV-2 positive

What are the major findings of long COVID research?

Exploring bioinformatics approach for evaluating binding affinities of probable COVID-19 therapeutic decoys

New Pyk2-derived peptide inhibits breast cancer metastasis

Study shows the modulatory effect of resistance training on the endoplasmic reticulum in older adults

S. aureus enhances replication of SARS-CoV-2 in vitro through the bacterial iron-regulated surface determinant protein A

Could drinking tea help manage COVID-19?

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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