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Study shows limitations of AAV gene therapy in treating hereditary adrenal disorders

A new study has definitively shown that a single treatment with gene therapy using adeno-associated viral (AAV) vector gene delivery to replace the defective gene responsible for congenital adrenal hyperplasia (CAH) will only temporarily alleviate the hereditary disorder.

29 Mar 2018

Topical solution may be less cytotoxic than cryosurgery for patients with seborrheic keratosis

Seborrheic keratosis is the most common noncancerous skin growth in adults seen by doctors in everyday practice.

29 Mar 2018

International researchers discover link between congenital heart defects and adrenal gland cancer

An international team led by Dr. Patricia Dahia, M.D., Ph.D., of UT Health San Antonio, discovered a genetic mutation that explains why adults with severe congenital heart defects--who live with low oxygen in their blood--are at dramatically high risk for adrenal gland cancer.

29 Mar 2018

Research pinpoints potential weak link in bacterial wall-building protein

The wall that surrounds bacteria to shield them from external assaults has long been a tantalizing target for drug therapies. Indeed, some of modern medicine's most reliable antibiotics disarm harmful bacteria by disrupting the proteins that build their protective armor.

28 Mar 2018

Phase I clinical trial of HIV vaccines to begin in the U.S.

A Phase I clinical trial testing the safety of vaccines that might have the potential to prevent HIV infection will begin this month at four sites in the United States, marking the latest step in a three-decade quest at UMass Medical School to harness the power of DNA vaccines in addressing a major global health threat.

28 Mar 2018

Researchers highlight the need to reconsider mitochondrial replacement moratorium

Mothers with mitochondrial DNA mutations often give birth to children who face incurable and fatal illnesses. But a much-studied form of mitochondrial replacement could prevent the transmission of such diseases from mothers to children, researchers say.

28 Mar 2018

Simple bedside test may help doctors diagnose certain degenerative brain diseases

A simple bedside test that matches a change in heart rate with a drop in blood pressure after a patient stands may help doctors diagnose certain degenerative brain diseases.

28 Mar 2018

Researchers discover important features of tumor cells that may help fight cancer

A research team led by Mónica Bettencourt Dias, from Instituto Gulbenkian de Ciência, discovered important features of cancer cells that may help clinicians fighting cancer.

28 Mar 2018

Students propose innovative concept to diagnose infectious diseases

Imagine a small paper device that can rapidly reveal from a drop of blood whether an infection is bacterial or viral. The device could help reduce the overuse of antibiotics – which kill bacteria, not viruses. Misuse of antibiotics has led to antimicrobial resistance, a growing global public health issue.

28 Mar 2018

Scientists demonstrate successful implementation of prosthetic memory system

Scientists at Wake Forest Baptist Medical Center and the University of Southern California (USC) have demonstrated the successful implementation of a prosthetic system that uses a person's own memory patterns to facilitate the brain's ability to encode and recall memory.

28 Mar 2018

Discovery holds potential to pave way for new synergistic drug combinations

New data from a study led by researchers from the University of Minnesota Medical School could change how future antimicrobial drug combinations are discovered and developed.

27 Mar 2018

Researchers measure whether transcranial direct current stimulation generates EFs in deep brain areas

A defining characteristic of stroke is the loss of motor control due to structural damage in specific brain areas. In fact, motor impairments (or deficits) are the number one complication after stroke.

27 Mar 2018

Study identifies genetic factors linked to severity of acute viral bronchiolitis

A scientific study conducted at the State University of Campinas (UNICAMP) in São Paulo State, Brazil, has identified genetic factors associated with the severity of acute viral bronchiolitis. The study was supported by the Sao Paulo Research Foundation - FAPESP. Its results were published in the journal Gene.

27 Mar 2018

New study reveals why some visual cues remain subliminal

Understanding conscious perception is a major challenge for neuroscience. A new study published on March 22nd in Science now shows why weak visual stimuli of the same strength are sometimes detected and other times remain subliminal: As the signals travel from visual areas to the prefrontal cortex, fluctuating brain dynamics can make the difference, elevating some signals above the threshold of conscious experience and stopping others in their tracks.

27 Mar 2018

Measurement of tumor's metabolic activity could help determine prostate cancer prognosis

A new approach to analyzing prostate gland tissue may help address a major challenge in treating prostate cancer - determining which tumors are unlikely to progress and which could be life threatening and require treatment.

27 Mar 2018

Medicare metrics may not completely reflect hospital quality for readmissions

Over the past several years, the Centers for Medicare & Medicaid Services have reported hospital quality measures on the Hospital Compare website, providing the public with a way to compare hospital performance.

27 Mar 2018

New device achieves 92% accuracy in detecting patients with severe stroke

A new device worn like a visor can detect emergent large-vessel occlusion in patients with suspected stroke with 92 percent accuracy, report clinical investigators at the Medical University of South Carolina, Mount Sinai, the University of Tennessee Health Sciences Center and elsewhere in an article published online on March 6, 2018, in the Journal of Neurointerventional Surgery.

26 Mar 2018

Researchers examine blood lead concentrations of Flint children before and after water crisis

Flint children's blood lead levels were nearly three times higher almost a decade before the year of the Flint water crisis, new research shows.

26 Mar 2018

Using machine learning to predict C. difficile infection risk

Researchers have developed a series of machine learning models that can predict a patient’s risk of infection by C. difficile, a gastrointestinal pathogen.

26 Mar 2018

The dream among ‘dreamers’ to become a doctor now ‘at the mercy’ of courts

Among the young people known as "Dreamers," Ever Arias belongs to a select group. Of the roughly 700,000 unauthorized immigrants who have temporary but tenuous protection from deportation, only 99 are in medical school. Fewer still have made it to their final year.

23 Mar 2018

Medical School News and Research

Study shows limitations of AAV gene therapy in treating hereditary adrenal disorders

Topical solution may be less cytotoxic than cryosurgery for patients with seborrheic keratosis

International researchers discover link between congenital heart defects and adrenal gland cancer

Research pinpoints potential weak link in bacterial wall-building protein

Phase I clinical trial of HIV vaccines to begin in the U.S.

Researchers highlight the need to reconsider mitochondrial replacement moratorium

Simple bedside test may help doctors diagnose certain degenerative brain diseases

Researchers discover important features of tumor cells that may help fight cancer

Students propose innovative concept to diagnose infectious diseases

Scientists demonstrate successful implementation of prosthetic memory system

Discovery holds potential to pave way for new synergistic drug combinations

Researchers measure whether transcranial direct current stimulation generates EFs in deep brain areas

Study identifies genetic factors linked to severity of acute viral bronchiolitis

New study reveals why some visual cues remain subliminal

Measurement of tumor's metabolic activity could help determine prostate cancer prognosis

Medicare metrics may not completely reflect hospital quality for readmissions

New device achieves 92% accuracy in detecting patients with severe stroke

Researchers examine blood lead concentrations of Flint children before and after water crisis

Using machine learning to predict C. difficile infection risk

The dream among ‘dreamers’ to become a doctor now ‘at the mercy’ of courts

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