Antiretroviral News and Research

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HIV trial points to semaglutide as a new anti-aging contender

Once-weekly semaglutide significantly slowed epigenetic aging in adults with HIV-associated lipohypertrophy, as measured by multiple DNA methylation clocks in a randomized controlled trial. These exploratory findings suggest GLP-1 receptor agonists could impact biological aging but require further validation in broader populations.

4 Aug 2025

Single injection of gene therapy at birth may offer lasting protection against HIV

A new study in Nature shows that delivering a single injection of gene therapy at birth may offer years-long protection against HIV, tapping into a critical window in early life that could reshape the fight against pediatric infections in high-risk regions.

30 Jul 2025

Australian study uncovers first potential prophylactic treatment against HTLV-1

Around 10 million people globally live with the life-threatening virus HTLV-1. Yet it remains a poorly understood disease that currently has no preventative treatments and no cure.

21 Jul 2025

Many HIV-exposed newborns miss preventive treatment after birth

Newborns exposed to HIV during pregnancy or birth should receive preventive antiretroviral medication immediately after delivery to reduce the risk of transmission from mother to child.

16 Jul 2025

New WHO guidelines recommend injectable lenacapavir for HIV prevention

The World Health Organization (WHO) released today new guidelines recommending the use of injectable lenacapavir (LEN) twice a year as an additional pre-exposure prophylaxis (PrEP) option for HIV prevention, in a landmark policy action that could help reshape the global HIV response.

14 Jul 2025

Research highlights an increase in informal use of doxyPEP/PrEP among key populations in the Netherlands

New research analyzing an online survey of 1,633 respondents found 15% recent use of doxycycline post- and pre-exposure prophylaxis (doxyPEP/PrEP) among men who have sex with men (MSM), transgender and gender diverse people in the Netherlands according to a recent study published by Eurosurveillance.

4 Jul 2025

HIV treatment linked to risk of early knee osteoarthritis

Acquired immune deficiency syndrome, or AIDS, caused by the human immunodeficiency virus (HIV), weakens the body's immune system and can be life-threatening if left untreated.

1 Jul 2025

UVA researchers discover key to HIV latency and reactivation

University of Virginia School of Medicine scientists have uncovered a key reason why HIV remains so difficult to cure: Their research shows that small changes in the virus affect how quickly or slowly it replicates, and how easily or stubbornly it can reawaken from hiding.

29 May 2025

Older adults in sub-Saharan Africa face growing HIV epidemic

Prevention and treatment campaigns are not adequately targeting the particular needs of the 50+ years age group.

15 May 2025

Loss of drug subsidies linked to higher mortality among low-income Medicare beneficiaries

While it may seem intuitive that people would die without life-saving medications, Penn and Harvard researchers have connected losing a federally funded prescription drug assistance program and an increase in mortality.

14 May 2025

HIV uses circular RNAs to evade immunity and boost replication

In a groundbreaking discovery, researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine have identified a never-before-seen mechanism that enables the human immunodeficiency type 1 virus (HIV-1) to evade the body's natural defenses and use it to support its survival and replication.

13 May 2025

WHO Results Report 2024 shows progress on global health goals amid financial uncertainties

The World Health Organization (WHO) Results Report 2024, shows progress on global health goals, even in times of growing financial uncertainties.

12 May 2025

Long-acting HIV drug emerges from decades of research and advocacy

In the hunt for a remedy, when the baton is passed from dedicated academic scientists to an innovative company to trusted community advocates, outcomes for society can be especially powerful.

8 May 2025

Home injections for HIV treatment show equal safety and satisfaction

Long-acting injectable antiretroviral therapy (ART) can be administered at home to persons living with HIV as safely and effectively by a health care professional as in the clinic, with equally high patient satisfaction rates, according to a new study conducted by MUSC Health Infectious Diseases clinician Eric Meissner, M.D., Ph.D., an associate professor in the College of Medicine.

30 Apr 2025

Experts warn of rising HIV deaths with planned aid cuts

Global deaths from HIV/AIDS and new infections could soar to levels unseen since the start of the century if planned funding cuts to foreign aid are sustained, undermining years of progress, experts warn.

8 Apr 2025

NIH funds research to develop a game-changing HIV diagnostic tool

As of the end of 2023, nearly 40 million people worldwide were living with HIV, including approximately 1.2 million in the United States.

1 Apr 2025

Six promising biomarkers could improve early and accurate detection of kidney injury

Critical Path Institute® (C-Path) and Boston Medical Center (BMC) published results for six biomarkers that could improve the early and accurate detection of kidney injury, leading to both the development of safer medications and better health outcomes for all patients.

28 Mar 2025