Arginine is considered a semi-essential amino acid because even though the body normally makes enough of it, supplementation is sometimes needed. For example, people with protein malnutrition, excessive ammonia production, excessive lysine intake, burns, infections, peritoneal dialysis, rapid growth, urea synthesis disorders, or sepsis may not have enough arginine. Symptoms of arginine deficiency include poor wound healing, hair loss, skin rash, constipation, and fatty liver.
Arginine changes into nitric oxide, which causes blood vessel relaxation (vasodilation). Early evidence suggests that arginine may help treat medical conditions that improve with vasodilation, such as chest pain, clogged arteries (called atherosclerosis), coronary artery disease, erectile dysfunction, heart failure, intermittent claudication/peripheral vascular disease, and blood vessel swelling that causes headaches (vascular headaches). Arginine also triggers the body to make protein and has been studied for wound healing, bodybuilding, enhancement of sperm production (spermatogenesis), and prevention of wasting in people with critical illnesses.
Arginine hydrochloride has a high chloride content and has been used to treat metabolic alkalosis. This use should be under the supervision of a qualified healthcare professional.
The review introduces the molecular subtypes of breast cancer and outlines how altered amino acid metabolism supports tumor growth.
A narrative review in The Journal of Nutrition suggests that whole-food plant diets may help prevent or improve erectile dysfunction (ED) by supporting vascular health and reducing risk factors such as LDL cholesterol and inflammation. However, most evidence is observational, and more clinical trials are needed.
An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to produce heat through a process known as thermogenesis, thereby promoting weight loss.
Researchers develop a self-regulating mRNA medicine that adjusts protein production based on disease-related signals.
Researchers from the Institute for Molecular Science (IMS)/SOKENDAI and Kyushu University have uncovered the molecular mechanism that drives the "ticking" of the circadian clock in cyanobacteria.
Recent advances in cancer research have underscored the critical role of myeloid cells in shaping tumor microenvironments (TME), influencing tumor progression, immune evasion, and therapeutic resistance.
A recent study involving 684 Chinese adults has uncovered a significant connection between gut microbiota, aging, and bone health, particularly in relation to osteoporosis, a condition that weakens bones and increases the risk of fractures.
A study of 634 allergy patients in Tenerife found that 22% were sensitized to edible insects—often without ever consuming them, due to cross-reactivity with house dust mites. Tropomyosin and arginine kinase were key shared allergens, but a subset reacted to unknown insect proteins, raising new concerns about emerging food allergies.
Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.
In this interview Prof. Dr. Kristina Kusche-Vihrog speaks about the nanomechanics of living cells and their implications for cardiovascular disease.
Researchers explored L-arginine-loaded lipid nanoparticles from fenugreek seed oil, finding they enhance drug stability and bioavailability, showing promise for diabetes treatment.
The root causes of most forms of Alzheimer's disease largely remain a mystery. Now, researchers have revealed a new piece of the puzzle.
Researchers develop targeted polymersomes loaded with methotrexate for the treatment of gestational choriocarcinoma,
A new research paper was published in Volume 16 of Genes & Cancer on January 20, 2025, entitled, "Analysis of pathogenic variants in retinoblastoma reveals a potential gain of function mutation."
Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the nomination of ISM1745, a potentially best-in-class MTA cooperative PRMT5 inhibitor with AI-powered novel scaffold, as preclinical candidate (PCC) for the treatment of MTAP-deleted cancers.
Hepatitis B virus (HBV) infection is a leading cause of chronic liver diseases, that spreads among individuals through blood or body fluids.
A team led by Specially Appointed Associate Professor Tomohiko Ishihara and Professor Osamu Onodera at Niigata University, along with Professor Yoshitaka Nagai at Kindai University, conducted a randomized, double-blind trial on the efficacy and safety of L-arginine in treating Spinocerebellar ataxia type 6 (SCA6).
CBT and combined rehabilitation offer moderate benefits for long COVID, enhancing quality of life and reducing fatigue, but evidence quality is variable.
The FCM protein snack bar, rich in amino acids and antioxidants, improves brain function and memory accuracy in just six weeks, according to recent research.
A new Scientific Statement released today by the Endocrine Society highlights research gaps associated with the negative effects of opioid use on the endocrine system.
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