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Spatial patterns of cortical microstructural change can be early indicators of Alzheimer's disease risk

Findings from a novel study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, published by Elsevier, suggest that using a specialized diffusion weighted MRI scan to monitor the spatial pattern of individual cortical microstructural change in the brain may be a promising approach to characterize individuals who may be vulnerable to developing Alzheimer's disease (AD) prior to significant cognitive decline and irreversible neuronal damage.

30 Jul 2024

Associations between gut microbes and Alzheimer’s disease

Researchers reviewed existing data on the role of the gut microbiome in Alzheimer’s disease (AD) pathogenesis.

24 Jul 2024

Concussions in retired rugby players linked to higher neurodegenerative disease biomarkers

A study in the International Journal of Molecular Sciences reveals that retired rugby players with a history of concussions exhibit significant differences in biomarkers associated with neurodegenerative diseases compared to non-contact sports participants.

21 Jul 2024

Concussion history in rugby players linked to higher levels of neurodegenerative disease biomarkers

Retired rugby players who have suffered multiple concussions have higher levels of certain proteins in their blood, which may make them more prone to developing diseases such as motor neurone disease (MND), according to a new study.

17 Jul 2024

Hormone modulating therapy may lower dementia risk in breast cancer survivors

Hormone modulating therapy (HMT) used for the treatment of breast cancer was associated with a 7% lower risk of developing Alzheimer's disease and related dementias later in life, according to a new study published today in JAMA Network Open.

16 Jul 2024

Few UK Alzheimer's patients suitable for new disease-modifying drugs, study finds

Few people in the UK with early stage Alzheimer's disease are likely to be suitable for the latest drugs which aim to halt progress of the condition, yet many are nevertheless likely to be referred for these treatments, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

11 Jun 2024

Can lifestyles changes reduce Alzheimer’s risk?

Intensive lifestyle changes significantly improve cognition and function in patients with mild cognitive impairment or early dementia due to Alzheimer’s disease over a 20-week period, showing promising results for non-pharmacological interventions.

10 Jun 2024

Western diet linked to chronic diseases by gut microbiota disruption

The Western diet disrupts gut microbiota and gut barrier function, increasing the risk of non-communicable chronic diseases through chronic low-grade inflammation.

13 May 2024

New sleep-enhancing nutraceutical blend falls short in clinical trial

Study investigates the impact of a unique nutraceutical blend, combining L-theanine with valerian, saffron, and lemon balm extracts, on improving sleep quality, finding no significant difference compared to a placebo in individuals experiencing poor sleep.

10 Apr 2024

Study adds new evidence on the link between Type 2 diabetes and Alzheimer's disease

New research conducted in mice offers insights into what's going on at the molecular level that could cause people with diabetes to develop Alzheimer's disease.

25 Mar 2024

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases.

21 Mar 2024

Study uncovers mutation impacting Alzheimer's progression

The scientist of the Faculty of Medicine of the University of Malaga José Luis Royo has coordinated a study that summarizes eight years of research and brings together 100 multidisciplinary specialists, identifying a mutation that alters Alzheimer's disease progression.

15 Mar 2024

Study links blast-related brain injuries in veterans to early Alzheimer's markers

U.S. veterans of the wars in Afghanistan and Iraq who suffered mild traumatic brain injury from exposure to explosive blasts were found to have changes in cerebrospinal fluid proteins that are typically seen in people who develop Alzheimer's disease, according to researchers at the University of Washington School of Medicine and VA Puget Sound Health Care System.

13 Mar 2024

Neuropsychiatric symptoms can be potential predictors of Alzheimer's development

As the years add up, it's common to notice slight changes in our ability to remember and think. Older people who have more marked changes than their peers can be diagnosed with mild cognitive impairment (MCI).

26 Feb 2024

Researchers discover mechanism to reverse amyloid plaque assembly in Alzheimer's disease

University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures.

22 Feb 2024

Researchers introduce a pioneering approach to combat neurodegenerative diseases

Researchers led by Northwestern University and the University of Wisconsin-Madison have introduced a pioneering approach aimed at combating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis (ALS).

16 Feb 2024

Experts join forces to define recommendations for biomarker-based diagnosis of Alzheimer’s disease

A multidisciplinary working group of 22 experts from eleven European scientific associations have joined forces to define recommendations for the effective and individualized use of biomarkers for the diagnosis of Alzheimer’s disease in memory clinics.

15 Feb 2024

UH Brain Health & Memory Center now treating patients with FDA-approved drug for Alzheimer's disease

University Hospitals (UH) Brain Health & Memory Center is now treating patients with LEQEMBI (lecanemab), a Food and Drug Administration-approved medication for the treatment of Alzheimer's disease.

9 Feb 2024

Interdisciplinary dream team receives $3 million grant to revolutionize Alzheimer's diagnosis

What do a synthetic chemist, a medical imaging expert, and a neurologist have in common? They're coming together in the Biomedical Imaging Center at the Beckman Institute for Advanced Science and Technology to develop better diagnostic tools and imaging agents to detect early-stage Alzheimer's disease and other neurodegenerative diseases.

6 Feb 2024

UNC scientists develop "smart" patch for precision drug delivery

University of North Carolina at Chapel Hill scientists created a new drug delivery system, called the Spatiotemporal On-Demand Patch (SOP), which can receive commands wirelessly from a smartphone or computer to schedule and trigger the release of drugs from individual microneedles.

18 Jan 2024