Researchers discover mechanism to reverse amyloid plaque assembly in Alzheimer's disease

NewsGuard 100/100 Score

University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures.

A new research paper published on Jan. 26 in Nature Communications reveals groundbreaking structural details into how diseases form much like Alzheimer's disease. With this knowledge, the group may have uncovered a unique mechanism to reverse both the deposits and their impact on those suffering from these conditions.

UNC-Chapel Hill researcher Ronit Freeman is leading a research group with investigators from the Lynn lab at Emory University looked at the core beta amyloid-42 peptide, the key portion driving amyloid plaque assembly and deposits in the brains of patients with Alzheimer's disease. By creating synthetic variations of the peptide in the lab, they were able to discover how to control the way that these molecules assemble and twist. 

The ability of these amyloid materials to be untwisted and degraded highlights potential for treatments modifying and subsequently reversing plaques found in Alzheimer's, and other neurodegenerative diseases. We know that the direction of the amyloid fibril twists is associated with different disease progression states. Imagine that by a simple treatment, we could modify amyloids to change their shape and disappear – this is what our discovery might enable us to do in the future."

Ronit Freeman, Researcher, UNC-Chapel Hill

Using advanced spectroscopic techniques, the researchers probed how individual peptides interact, revealing information about assembly rates, distances between peptides, peptide alignment, and importantly the direction of twist. High-resolution electron and fluorescent microscopy were used to characterize the morphology of the materials at different temperatures.

The investigators identified that the N-terminal domain of the peptide is important for programming the shape of the assembly such as tubes, ribbons, or fibers, while C-terminal modifications direct either a left- or right-handed twist within the material. Using these design rules, a series of peptides were tuned to switch on-demand between left-handed and right-handed twisted ribbons in response to changing temperatures. This twist inversion then renders the material susceptible to degradation by natural proteins, a desirable feature for materials used as delivery vehicles.

Source:
Journal reference:

Klawa, S. J., et al. (2024). Uncovering supramolecular chirality codes for the design of tunable biomaterials. Nature Communications. doi.org/10.1038/s41467-024-45019-2.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Research from NY highlights pollution as a key factor in rising cancer rates among youth