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Why measles remains one of the most contagious viral diseases worldwide

This review synthesizes current evidence on measles virus biology, immune responses, complications, treatments, and prevention strategies. It highlights how measles can suppress immune memory, increasing susceptibility to other infections, and underscores vaccination as the most effective control measure.

4 Mar 2026

Researchers uncover vulnerabilities in elusive HIV reservoir clones

A new study has overcome a long-standing challenge-how to isolate and study elusive HIV-infected cells called authentic reservoir clones (ARCs) that evade the immune system, making the disease difficult to cure.

24 Feb 2026

Single-cell RNA sequencing reveals accelerated T cell aging in viral infections

A new research paper was published in Volume 18 of Aging-US on February 8, 2026, titled "Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV."

19 Feb 2026

Precision mRNA vaccine strategy shows early promise for improving TNBC relapse risk

An individualized neoantigen mRNA vaccine was tested in patients with early-stage triple-negative breast cancer and showed feasibility, safety, and strong T cell immune responses. Long-term follow-up suggested durable immune memory with encouraging relapse-free outcomes, though controlled trials are needed to confirm clinical benefit.

19 Feb 2026

Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

Researchers engineered CD4+ chimeric antigen receptor T cells targeting fibrillar amyloid beta and tested them in a mouse Alzheimer model. The preclinical study showed reduced amyloid pathology and altered neuroimmune responses, supporting CAR-T immunotherapy as a potential future Alzheimer strategy.

11 Feb 2026

Engineered CAR-T cells reduce Alzheimer’s plaques in mice

Chimeric antigen receptor (CAR) T cell therapy, a type of immunotherapy that leverages the immune system to combat diseases, is a powerful treatment option for certain cancers.

9 Feb 2026

EBV-linked killer T cells implicated in multiple sclerosis

Researchers at UC San Francisco have uncovered a new clue to how Epstein-Barr virus (EBV) could contribute to multiple sclerosis (MS), a chronic autoimmune disease that affects nearly one million Americans.

5 Feb 2026

Immune system dysfunction may fuel progressive heart failure after heart attacks

When the heart's muscle is weakened or injured due to a heart attack, it can make it hard for the heart to pump enough blood to meet the body's needs.

27 Jan 2026

Brain organoids reveal glioblastoma's secrets and therapy resistance

UCLA scientists have developed advanced miniature 3D tumor organoid models that make it possible to study glioblastoma tumors in a setting that closely mirrors the human brain, shedding light on how the aggressive cancer interacts with surrounding brain cells and the immune system to become more invasive and resistant to therapy.

27 Jan 2026

Chemotherapy-induced gut changes trigger anti-metastatic immune response

Chemotherapy commonly damages the intestinal lining, a well-known side effect. But this injury does not remain confined to the gut.

22 Jan 2026

Immune dysfunction persists after combined TB and HIV therapy

The immune system remains seriously out-of-whack – in an inflammatory state of overactivation and impaired functionality – following the international gold standard for treating people with latent tuberculosis (TB) and HIV, a team at Texas Biomedical Research Institute reports in Nature Communications.

14 Jan 2026

Aston Sci. Inc. implements CDD Vault to support AI-driven cancer vaccine development

Aston Sci. Inc., a clinical-stage biopharmaceutical company pioneering next-generation therapeutic cancer vaccines, announced today that it has implemented CDD Vault®, the secure, cloud-based research informatics platform from Collaborative Drug Discovery (CDD).

From Collaborative Drug Discovery, Inc. 10 Jan 2026

UBC researchers crack code to grow helper t cells from stem cells

For the first time, researchers at the University of British Columbia have demonstrated how to reliably produce an important type of human immune cell-known as helper T cells-from stem cells in a controlled laboratory setting.

8 Jan 2026

Soft wireless bioelectronic implant targets the splenic nerve to reduce inflammation

For millions suffering from chronic inflammatory diseases like inflammatory bowel disease (IBD), managing flare-ups often involves powerful drugs with significant side effects.

1 Jan 2026

Polysaccharide functionalized carbon dot nanovaccine boosts antitumor T cell responses

Recent advancements in cancer vaccine development have demonstrated their potential for precise tumor targeting through antigen-specific immune activation.

23 Dec 2025

Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of inducing antigen-specific regulatory T cells (Tregs), the immune cells that play a central role in suppressing excessive immune responses.

22 Dec 2025

Chemotherapy may reduce HIV-infected T cells

Advancements in HIV/AIDS research, drug development and clinical practice since the 1980s have made it possible for people living with HIV to lead long, productive lives and keep the virus in check at undetectable levels and nontransmissible as long as therapy is maintained.

15 Dec 2025

Unnecessary gluten-free diets may put children at risk

Understanding gluten-related disorders is crucial for pediatric nutrition, as gluten-free diets can pose health risks without appropriate medical supervision.

15 Dec 2025

New findings show why the human intestine uniquely presents gluten to T cells

Human intestinal M cells function as dendritic cell-like antigen-presenting cells, displaying constitutive MHC-II activity and specialized machinery for processing gluten. Their ability to deamidate and present gliadin peptides positions them as key initiators of immune responses relevant to coeliac disease.

11 Dec 2025

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion, tumor heterogeneity, and immune-related adverse events.

11 Dec 2025

CD4 News and Research

Why measles remains one of the most contagious viral diseases worldwide

Researchers uncover vulnerabilities in elusive HIV reservoir clones

Single-cell RNA sequencing reveals accelerated T cell aging in viral infections

Precision mRNA vaccine strategy shows early promise for improving TNBC relapse risk

Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

Engineered CAR-T cells reduce Alzheimer’s plaques in mice

EBV-linked killer T cells implicated in multiple sclerosis

Immune system dysfunction may fuel progressive heart failure after heart attacks

Brain organoids reveal glioblastoma's secrets and therapy resistance

Chemotherapy-induced gut changes trigger anti-metastatic immune response

Immune dysfunction persists after combined TB and HIV therapy

Aston Sci. Inc. implements CDD Vault to support AI-driven cancer vaccine development

UBC researchers crack code to grow helper t cells from stem cells

Soft wireless bioelectronic implant targets the splenic nerve to reduce inflammation

Polysaccharide functionalized carbon dot nanovaccine boosts antitumor T cell responses

Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

Chemotherapy may reduce HIV-infected T cells

Unnecessary gluten-free diets may put children at risk

New findings show why the human intestine uniquely presents gluten to T cells

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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