Crohn’s Disease News and Research

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Janssen-Cilag seeks European approval for guselkumab in ulcerative colitis and Crohn’s disease treatment

Janssen-Cilag International NV, a Johnson & Johnson company, today announced it has submitted applications to the European Medicines Agency (EMA) seeking to expand the Marketing Authorization Application for TREMFYA® (guselkumab) to include the treatment of adult patients with moderately to severely active ulcerative colitis and moderately to severely active Crohn’s disease.

6 May 2024

Therapeutic potential of human umbilical cord-derived mesenchymal stem cells in Crohn’s disease

Whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) could heal luminal ulcers in Crohn’s disease.

25 Apr 2024

Immune responses in mesenteric lymph nodes improve understanding of Crohn's disease

Crohn's disease is a chronic inflammatory bowel disease that is sometimes insufficiently controlled by immunosuppressive therapies with a subsequent need for surgical removal of affected bowel segments.

25 Mar 2024

Implantable temperature sensor detects inflammatory flareups in patients with Crohn's disease

A team of Northwestern University scientists has developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease.

18 Mar 2024

Living with IBD: What coping strategies are most effective?

The results of a systematic review that explored the impact of different coping strategies for people living with inflammatory bowel disease (IBD).

14 Mar 2024

Scientists uncover an overlooked mechanism in the gut immune system of Crohn's disease patients

A team of scientists from DTU and other European universities have uncovered an overlooked mechanism in the gut immune system of patients suffering from severe cases of Crohn's disease.

13 Mar 2024

How does childhood exposure to agricultural land influence inflammatory bowel disease risk?

The impact of environmental exposures in early life on the risk of inflammatory bowel disease (IBD), ulcerative colitis (UC), and Crohn’s disease (CD).

13 Mar 2024

Pregnant women with autoimmune conditions at a greater risk of developing adverse pregnancy outcomes, study suggests

Researchers analyzed systematic reviews conducted on the association between autoimmune diseases and pregnancy outcomes.

8 Mar 2024

Is there a higher risk of depression among specific populations of patients with rheumatoid arthritis?

Researchers assessed the risk of depression following the diagnosis of rheumatoid arthritis (RA).

8 Mar 2024

Study links ultra-processed foods to gut health risks

A review in Nature Reviews Gastroenterology & Hepatology synthesizes evidence on the negative impacts of ultra-processed foods and food additives on gut health, linking them to chronic diseases and alterations in the gut microbiome.

25 Feb 2024

Study: Early advanced therapy significantly improves Crohn's disease outcomes

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

22 Feb 2024

Is inflammatory bowel disease causing your erectile dysfunction?

The causal link between erectile dysfunction (ED) and inflammatory bowel disease (IBD).

29 Jan 2024

Mount Sinai project receives $4M grant to understand the early stages of Crohn's disease

The Icahn School of Medicine at Mount Sinai has been awarded a grant of more than $4 million from The Leona M. and Harry B. Helmsley Charitable Trust to support an innovative research project aimed at understanding the early stages of Crohn's disease before noticeable symptoms develop.

25 Jan 2024

From gut to brain: How diet can influence Alzheimer's and Parkinson's outcomes

Diet modification and alterations in the intestinal microbial population could impact the disease course of Alzheimer’s and Parkinson’s diseases.

23 Jan 2024

Migraine linked to increased risk of inflammatory bowel disease in new study

A nationwide cohort study reveals that individuals with migraine have a 1.3-fold higher risk of developing inflammatory bowel disease (IBD), suggesting a significant connection between migraine and IBD.

15 Jan 2024

Nicotine's surprising effect on gut microbiota and metabolism uncovered

The impact of nicotine exposure on host nutritional status, gut microbial metabolites, and metabolic homeostasis.

15 Jan 2024

Fiber-free diet key to treating childhood Crohn's disease, new study finds

Research reveals how a fiber-free diet in Exclusive Enteral Nutrition (EEN) helps treat Crohn's disease in children by affecting the intestinal pathobiont Mucispirillum schaedleri. It shows that this diet alters gut microbiota, reducing Mucispirillum's pathogenicity and aiding in managing colitis.

26 Nov 2023