Familial Adenomatous Polyposis News and Research

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Hereditary form of colon cancer traced to common ancester in U.S.

A married couple who sailed from England to America around 1630 may be the ancestors of hundreds of people alive today who are at risk for a hereditary form of colon cancer.

3 Jan 2008

VIOXX reduces risk of colorectal polyps

A researcher from Dartmouth reports the results of a clinical trial that shows that the cyclooxygenase-2 (COX-2) inhibitor rofecoxib (VIOXX.) reduces the risk of colorectal adenomas, or polyps.

30 Aug 2006

Oxy-Q may help prevent colon cancer

A pilot clinical trial demonstrates that Oxy-Q, a proprietary pill by Farr Laboratories, LLC that combines the active components of turmeric and onions, reduces both the size and number of precancerous colon polyps.

8 Aug 2006

Curry compound may prevent colon cancer

According to the results of a small study compounds found in curry and onions may help prevent colon cancer in those at risk.

3 Aug 2006

Chemicals in curry and onions may help prevent colon cancer

A small but informative clinical trial by Johns Hopkins investigators shows that a pill combining chemicals found in turmeric, a spice used in curries, and onions reduces both the size and number of precancerous lesions in the human intestinal tract.

1 Aug 2006

New test spares couples with familial cancer the trauma of termination

A new way of sparing couples the trauma of having to decide between having a baby with a high risk of developing a form of colorectal cancer later in life, or terminating the pregnancy, will be revealed on Tuesday, 20 June 2006.

19 Jun 2006

Exercise shown to protect against skin and bowel cancer

Two studies have shown that exercise can protect against skin and bowel cancer, and they have identified new mechanisms that could be responsible for this effect.

17 May 2006

Exercise, diet may protect against colorectal cancer

Voluntary exercise and a restricted diet reduced the number and size of pre-cancerous polyps in the intestines of male mice and improved survival, according to a study by a University of Wisconsin-Madison research published in the journal Carcinogenesis.

16 May 2006

Introgen's INGN 241 combined with Celebrex kills breast cancer cells

Introgen Therapeutics, Inc. today reported the publication of preclinical data demonstrating that INGN 241 works synergistically with celecoxib (Celebrex) marketed by Pfizer to inhibit the growth and increase apoptosis (cell death) of breast cancer cells.

8 Nov 2005

Baby gene tests safety should be checked

Experts are warning that the long-term safety of screening embryos for genetic diseases is going unchecked.

26 Apr 2005

Research reveals a novel key player in the initiation of colon cancer

Gastric and colorectal cancers account for more than 1 million deaths worldwide every year and several research groups have been working to identify the molecular events that result in the initiation and progression of these tumors.

3 Feb 2005

Study links meat consumption to colon cancer

A major American Cancer Society study finds people who reported the highest consumption of red and processed meat had a significantly higher risk of colorectal cancer than those who reported the least consumption.

12 Jan 2005

Celebrex suspension

The National Institutes of Health (NIH) announced that it has suspended the use of COX-2 inhibitor celecoxib (Celebrex™ Pfizer, Inc.) for all participants in a large colorectal cancer prevention clinical trial conducted by the National Cancer Institute (NCI).

19 Dec 2004

Cyclooxygenase (COX) inhibitors tested in both prevention and treatment clinical trials

Numerous compounds are examined by the National Cancer Institute (NCI) for their potential to prevent or treat cancer. One class of compounds, cyclooxygenase (COX) inhibitors, is currently being tested in both prevention and treatment clinical trials.

4 Nov 2004

The Human Fertilisation and Embryology Authority has issued a preimplantation genetic diagnosis (PGD) licence for inherited colon cancer

The Human Fertilisation and Embryology Authority has confirmed that it has issued a preimplantation genetic diagnosis (PGD) licence for Familial Adenomatous Polyposis Coli (FAP) to the Assisted Conception Unit at University College Hospital, London.

2 Nov 2004

Gene mutations cause 85 percent of colon cancers

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene have been found to cause 85 percent of colon cancers.

9 Sep 2004

Proteomics helps fight colon cancer

Using new technology associated with the study of proteins, or proteomics, scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and their colleagues have made a step toward predicting which people with familial adenomatous polyposis.

19 Apr 2004

Proteomics techniques to find a possible predictor of response in a chemoprevention trial

16 Apr 2004

Discovery of novel gene profile that may identify colon stem cells

Researchers at Jefferson Medical College have uncovered a novel pattern of gene expression in the stem cell-rich bottom of tiny “crypts” in the tissue lining the colon. By identifying these patterns, the scientists hope to be able to identify mechanisms through which stem cells contribute to the development of colon cancer.

30 Mar 2004