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Exercise boosts immune defense in Lynch syndrome patients

Aerobic exercise, specifically cycling, shows promise in reducing inflammation and boosting immune responses in the colonic tissue of Lynch syndrome patients, a group at high risk for colorectal cancer. The study suggests that regular exercise may offer a preventive approach for this patient population, though further randomized trials are needed.

24 Sep 2023

CST and Leica Biosystems partner to enable companion diagnostics for personalized medicine

Cell Signaling Technology (CST), a life science discovery technology company and leading provider of antibodies, kits, and services, is partnered with Leica Biosystems, a technology leader in automated staining and brightfield and fluorescent imaging, to support the development of companion diagnostics (CDx) assays using the extensive portfolio of best-in-class antibodies from CST validated for immunohistochemistry (IHC).

From Cell Signaling Technology 20 Sep 2023

Single-cell screening of cerebral organoids to identify developmental defects in autism

Researchers develop CRISPR-human organoids-single-cell RNA sequencing system to identify developmental brain defects in autism.

18 Sep 2023

Flexible Spatial Biology Solution for Up to 8-Plex Amplification in Two Days: CST Launches SignalStar™ Multiplex IHC

Cell Signaling Technology (CST), a life science discovery technology company and leading provider of antibodies, kits, and services, today announced the launch of its SignalStar Multiplex IHC technology, a revolutionary new tool for spatial biology research using mid-plex, high-throughput immunohistochemistry (IHC) assays.

From Cell Signaling Technology 14 Sep 2023

Arf1 inhibition induces tumor regression by promoting T cell infiltration

In recent years, cancer immunotherapies, represented by immune checkpoint blockade (ICB), have been highly successful and have become an important basis for the future treatment of cancers.

12 Sep 2023

Does dahlia flower extract have anti-diabetic properties?

The effects of an extract of yellow petals of Dahlia pinnata as a novel treatment of type 2 diabetes (T2D).

6 Sep 2023

Study shows that CD98hc can be targeted to deliver biotherapeutics in brain

Researchers engineered and characterized a blood-brain barrier transport vehicle targeting the CD98 heavy chain of heterodimeric amino acid transporters.

24 Aug 2023

The future of medicine: Physicians need new skills to use AI in clinical decision making

As artificial intelligence systems like ChatGPT find their way into everyday use, physicians will start to see these tools incorporated into their clinical practice to help them make important decisions on diagnosis and treatment of common medical conditions.

8 Aug 2023

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Study identifies gene fusions to understand their relationship with observed pathologies in cancer patients.

8 Aug 2023

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Researchers investigate whether M2 macrophage-derived exosomes could prevent inflammation-associated damage during sepsis.

7 Aug 2023

Tumor-derived GDF-15 suppresses immunotherapy response

Researchers evaluate the impact of tumor-derived GDF-15 on responses to anti-PD-1 immunotherapy.

26 Jul 2023

New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Researchers reported on Nurr1 as a promising therapeutic target for managing Parkinson's disease (PD).

20 Jul 2023

How does SARS-CoV-2 affect the placenta during pregnancy?

Researchers examine host responses to SARS-CoV-2 within the placenta using transcriptomics.

12 Jul 2023

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Researchers evaluated the therapeutic efficacy of Navoximod.

13 Jun 2023

HER2-targeted antibody drug conjugate shows encouraging responses, long-lasting clinical benefit in several tumor types

In a new study of trastuzumab deruxtecan, a HER2-targeted antibody drug conjugate, researchers observed encouraging responses and long-lasting clinical benefit in several tumor types.

5 Jun 2023

Omicron BA.5 variant demonstrates increased neuroinvasiveness and pathogenicity in mice

Researchers assessed the extent of SARS-CoV-2 Omicron VOC BA.5 sub-VOC infection-associated brain infection and death.

5 Apr 2023

Targeting obesity: findings reveal a new molecular pathway involved in energy homeostasis regulation

Study outlines molecular mechanisms to aid the development of new therapies to manage obesity and associated health disorders.

29 Mar 2023

Detecting tissue-resident memory T cells in solid tumors

In this interview, NewsMedical talks with Cerba Research about in situ multiplex analysis of regulatory and effector T cells in tumors.

16 Mar 2023

Researchers report a physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel

Researchers developed spherical hydrogel inhalation for enhanced lung defense to protect against SARS-CoV-2 infections.

13 Feb 2023

Repression of endothelial TLR3 is a potential mechanism of SARS-CoV-2 infection-associated lung vascular remodeling

Researchers investigated whether endothelial TLR3 insufficiency contributes to lung vascular remodeling induced by SARS-CoV-2.

30 Jan 2023