Preclinical News and Research

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Biodegradable 'nanobone' material helps body regrow jawbone

For children born with cleft lip and palate, repairing gaps in the jawbone often means waiting until they are 10 to 12 years old before undergoing invasive bone graft surgery.

3 Sep 2026

Cancer drug eliminates HIV-infected cells in animal model study

Emory University researchers have provided the first proof-of-concept in a nonhuman primate model for eliminating HIV-infected cells with venetoclax, a clinically approved medication for cancer.

3 Sep 2026

Targeting KV7 proteins could help delay preterm labor

Scientists have found that targeting a particular group of proteins in the uterus muscle (myometrium) can suppress human uterine contractions in laboratory studies and delay preterm birth in a preclinical model.

3 Sep 2026

Menopause may start changing the gut years before periods stop

A longitudinal study of 964 women found that blood markers of gut epithelial barrier dysfunction and microbial product translocation began to rise around 2 to 2.5 years before the final menstrual period and remained elevated after menopause. The findings suggest that changes in gut barrier integrity may form part of the biological transition through menopause and could help explain links between menopause, inflammation, and later health outcomes.

2 Sep 2026

Why addiction researchers are paying closer attention to GLP-1 drugs

A Journal of Clinical Investigation Viewpoint highlights growing evidence that GLP-1 receptor agonists, particularly semaglutide, may reduce alcohol consumption and some other substance-related outcomes by acting on brain systems involved in reward, motivation, stress, and emotion. However, the authors caution that efficacy for substance use disorders is not yet firmly established and call for further research into optimal dosing, treatment duration, patient selection, mechanisms, and effects across different addictions.

2 Sep 2026

Blocking a naturally occurring molecule reverses deadly lung disease in preclinical models

Researchers blocked a naturally occurring molecule to reverse pulmonary arterial hypertension in preclinical models, a finding that could point to a new treatment approach for people with a rare and often fatal lung disease.

2 Sep 2026

New drug class shows major promise for shrinking nerve tumors

A scientist at Cincinnati Children's who has hunted for decades for ways to shrink the painful and disfiguring nerve tumors caused by neurofibromatosis type 1 (NF1) has made a new breakthrough in the quest.

2 Sep 2026

Two scientists win Horwitz Prize for Rett syndrome breakthrough

Columbia University will award the 2026 Louisa Gross Horwitz Prize to Adrian Bird and Huda Zoghbi for their pioneering work on epigenetic regulation in the nervous system and its role in human neurological disease, particularly Rett syndrome.

2 Sep 2026

Study links protein interaction to senescent cell survival

Senescent cells - cells that have stopped dividing but remain metabolically active - can accumulate with age and contribute to chronic inflammation and tissue dysfunction

1 Sep 2026

Study links human gut bacteria to levels of key chemicals in the brain

The neuroactive potential of bacteria living in the human gut is associated with levels of key chemicals in the brain, according to a new study from the University of Surrey and the University of Roehampton.

1 Sep 2026

AI platform uncovers new molecular targets for Alzheimer's disease

Groundbreaking study published in Alzheimer's & Dementia reveals the crucial links between the NAD⁺-mitophagy axis and neurodegeneration.

1 Sep 2026

New method based on human blood simplifies mRNA drug development

mRNA-based drugs are emerging as the drug of the future for a wide range of diseases, but they are difficult and time-consuming to develop.

1 Sep 2026

Multiple sclerosis treatment approach developed at Mainz University moves toward clinical application

A therapeutic approach pioneered in Mainz for the treatment of multiple sclerosis (MS) is taking an important step toward clinical application.

1 Sep 2026

Laser-based therapy shows promise against dangerous abdominal infections in children

Children whose appendix has burst often develop serious abdominal infections that are hard to treat and increasingly resistant to antibiotics.

1 Sep 2026

Adolescent binge drinking causes lasting changes in brain function

New research from the Marshall University Joan C. Edwards School of Medicine provides insight into how binge alcohol exposure during adolescence may cause lasting changes in brain function that persist into adulthood, potentially identifying a new target for future treatment approaches.

1 Sep 2026

New dual-drug strategy blocks triple-negative breast cancer growth

Triple-negative breast cancer (TNBC) has a frustrating ability to adapt. Although this aggressive form of breast cancer can initially respond well to chemotherapy, cancer cells often find ways to survive, allowing the disease to return and become resistant to treatment.

31 Aug 2026

Does a psychedelic need an awake brain to have lasting effects? This mouse study offers a clue

A single dose of psilocybin produced a lasting increase in sociability for at least two weeks in Cntnap2-knockout mice with social deficits, while it did not enhance sociability overall in mice with normal social behavior. The effect required 5-HT2A receptor activation and persisted when psilocybin was administered under light anesthesia, suggesting that wakefulness during the drug’s acute effects was not necessary for this behavioral response.

30 Aug 2026

Oral relaxin agonist AZD5462 improves cardiac function in heart failure patients

The oral relaxin agonist, AZD5462, improved cardiac function in patients with chronic heart failure, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in Circulation.

30 Aug 2026

FDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-Farber

The U.S. Food and Drug Administration (FDA) has approved daraxonrasib, an oral multi-selective RAS(ON) inhibitor, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or are not candidates for multiagent systemic therapy.

From Dana-Farber Cancer Institute, Inc. 29 Aug 2026

Primate-specific DNA change reveals a new link to dementia-related neurodegeneration

Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mechanisms may not be fully explained by conventional animal models.

29 Aug 2026

Preclinical News and Research

Biodegradable 'nanobone' material helps body regrow jawbone

Cancer drug eliminates HIV-infected cells in animal model study

Targeting KV7 proteins could help delay preterm labor

Menopause may start changing the gut years before periods stop

Why addiction researchers are paying closer attention to GLP-1 drugs

Blocking a naturally occurring molecule reverses deadly lung disease in preclinical models

New drug class shows major promise for shrinking nerve tumors

Two scientists win Horwitz Prize for Rett syndrome breakthrough

Study links protein interaction to senescent cell survival

Study links human gut bacteria to levels of key chemicals in the brain

AI platform uncovers new molecular targets for Alzheimer's disease

New method based on human blood simplifies mRNA drug development

Multiple sclerosis treatment approach developed at Mainz University moves toward clinical application

Laser-based therapy shows promise against dangerous abdominal infections in children

Adolescent binge drinking causes lasting changes in brain function

New dual-drug strategy blocks triple-negative breast cancer growth

Does a psychedelic need an awake brain to have lasting effects? This mouse study offers a clue

Oral relaxin agonist AZD5462 improves cardiac function in heart failure patients

FDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-Farber

Primate-specific DNA change reveals a new link to dementia-related neurodegeneration

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