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Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra). It is frequently called the 'blue pill'.

New erectile dysfunction treatment uses high-frequency acoustical waves

Statistically speaking, 50% of all men, have experienced erectile dysfunction (ED) at some time or another, and the chance of developing ED increases as you age. The medical management of ED has evolved greatly over the past several decades.

16 Dec 2016

Study could lead to potential new therapeutic target with fewer side effects for hypertension

A team of Vermont investigators has been issued a patent for their discovery of a molecule that rescues damaged blood vessels, yet preserves healthy vessels and could serve as a springboard for a new pharmaceutical therapy with fewer side effects for hypertension - a major risk factor for cardiovascular and kidney disease that effects roughly one in three people in the U.S.

15 Mar 2016

New blood biomarkers could lead to better evaluation of treatment for patients with PAH

New blood biomarkers reflecting vasoreactivity in lung blood vessels of patients with heart- and lung disease, can lead to simplified diagnostics and better evaluation of treatment for patients with the condition pulmonary arterial hypertension (PAH).

18 Jan 2016

Study offers insight into how female Viagra affects the brain

As the drug touted as "the female Viagra" comes to market, researchers at the University of Wisconsin-Madison are learning more about how the drug, called flibanserin, affects the brain.

13 Dec 2015

Can-Fite BioPharma reports financial results, provides updates on drug development programs

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs being developed to treat inflammatory diseases, cancer and sexual dysfunction, today reported financial results for the nine months ended September 30, 2015 and updates on its drug development programs.

27 Nov 2015

Sildenafil drug improves insulin sensitivity in people at risk for diabetes

The drug sildenafil, sold as Viagra and other brand names, improves insulin sensitivity in people at risk for diabetes, researchers at Vanderbilt University Medical Center reported today.

19 Nov 2015

Expert proposes new solution to current gridlock over regulation of dietary supplements

A former principal deputy commissioner of the U.S. Food and Drug Administration is proposing a solution to the current gridlock over the regulation of dietary supplements: Focus less on whether these vitamins, minerals and herbal extracts actually do what they claim and instead take important steps to improve their safety.

3 Nov 2015

U-M study suggests new therapeutic strategy for treating Duchene muscular dystrophy

Every heart beat and step in our daily lives is dependent on the integrity of muscles and the proteins that keep them strong and free of injury as they contract and relax.

27 Oct 2015

Even the Score issues statement on FDA approval of flibanserin for treatment of women with HSDD

Even the Score issued the following statement following today's historic approval by the Food and Drug Administration of flibanserin (Addyi), the first-ever medical treatment option for women's most common sexual dysfunction, known as Hypoactive Sexual Desire Disorder (HSDD).

18 Aug 2015

Scientists develop technique to identify Viagra and other hidden ingredients in dietary supplements

To lose weight, boost energy or soothe nerves, many consumers turn to dietary supplements. But some of these products contain undeclared substances. To protect consumers from taking something without their knowledge, scientists have developed a technique to determine what secret ingredients could be lurking in these supplements.

6 Aug 2015

Drugs used against impotence does not increase risk of malignant melanoma

Using drugs for impotence does not increase the risk of malignant melanoma, researchers from Umeå University in Sweden conclude in a publication in JAMA, a top US medical journal. These results contradict previous research indicating such an association.

23 Jun 2015

Study: Viagra, other related drugs not a universal 'cure-all' for impotence

Viagra and other related drugs are not a universal 'cure-all' for impotence, according to a new study from The University of Manchester and NatCen Social Research.

9 Apr 2015

Sildenafil drug may effectively relieve nerve damage in men with long-term diabetes

New animal studies at Henry Ford Hospital found that sildenafil, a drug commonly used to treat erectile dysfunction, may be effective in relieving painful and potentially life-threatening nerve damage in men with long-term diabetes.

18 Mar 2015

McGill researchers discover that lots of useful medical information getting lost

Lots of potentially useful medical information is getting lost. McGill researchers discovered this when they looked into the lack of reporting of information from "stalled drug" trials in cancer, cardiovascular and neurological diseases.

12 Mar 2015

Viagra can have anti-cancer, anti-Alzheimer's disease effects if used with new drugs

Chaperone proteins play an important role in protein folding in human cells and in bacteria and are promising new targets for drugs to treat cancer and Alzheimer's disease and for novel antiviral drugs and antibiotics. How existing drugs such as Viagra or Cialis and a derivative of the drug Celebrex, for example, can reduce the activity of a specific chaperone protein, with the potential for anti-tumor and anti-Alzheimer's disease effects, is described in a Review article in DNA and Cell Biology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

10 Mar 2015

Scientists to explore effectiveness of tadalafil drug to tackle vascular dementia

Scientists are to explore whether drugs usually used to treat erectile problems by expanding blood vessels could become the next major way to tackle the dementia epidemic.

11 Dec 2014

Can-Fite to commence pre-clinical development program of CF602 drug for sexual dysfunction

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs that address inflammatory and cancer diseases, today reported that it will initiate a pre-clinical development program of its next generation drug CF602 for the indication of sexual dysfunction. Upon successful completion, the company intends to file an IND with the FDA to allow human Phase I studies.

9 Dec 2014

Case Western Reserve researcher lands Director's New Innovator Awards from NIH

For the second consecutive year, a Case Western Reserve University School of Medicine researcher has landed one of the year's much-coveted Director's New Innovator Awards from the National Institutes of Health. Principal investigator Rong Xu, PhD, assistant professor of medical informatics, will receive $2,377,000 for five years, starting immediately, to initiate computational analysis of thousands of drugs and their effects.

8 Oct 2014

Drug and device news: Study questions medical devices' safety evidence

Elsewhere, The Associated Press reports on a new advertising approach for Viagra -- a TV commercial that targets women.

1 Oct 2014

ED more prevalent than previously thought

Specialists in treatment of erectile dysfunction recognize that ED is more prevalent than previously recognized.

29 Sep 2014