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Booster vaccination can reduce breakthrough infection risk in HIV patients

New study reveals that people with HIV are at a high risk of breakthrough COVID-19 infection in comparison to people without HIV, and that booster vaccinations can be protective for those living with HIV.

9 Dec 2021

Immune responses against SARS-CoV-2 Delta variant after BNT162b2 vaccination in people living with HIV

Researchers from Sorbonne Universite have been investigating the effect of the BNT162b2 mRNA vaccine on HIV-positive individuals.

9 Dec 2021

Increased risk of COVID-19 breakthrough infections in fully vaccinated people with HIV

New study results showed a 41% greater incidence of breakthrough infections in people with HIV compared to that of people without HIV.

9 Dec 2021

Exploring SARS-CoV-2 vaccine responsiveness in immunosuppressed patients

A new study indicates an immunological response to SARS-CoV-2 vaccines in immunosuppressed patients that were comparable to healthy patients.

7 Dec 2021

Immune response of Pfizer vaccinees who received Moderna or Pfizer booster

A new preprint discusses the immune boost resulting from homologous or heterologous booster doses in individuals fully vaccinated with two doses of the Pfizer vaccine.

7 Dec 2021

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

In a recent study conducted at Yale University, USA, scientists have investigated the immunogenicity of mRNA-based coronavirus disease 2019 (COVID-19) vaccine candidates encoding the spike proteins of different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. The findings reveal that the vaccines induce robust immune responses against SARS-CoV-2 variants. The study is currently available on the bioRxiv* preprint server.

6 Dec 2021

COVID-19 severity is correlated with T cell receptor repertoire signatures

In a new study published in the bioRxiv* preprint server, researchers found that specific TCR sequences predicted the severity of coronavirus disease 2019 (COVID-19) infection. Additionally, there was evidence of increased CDR3 sequences and changes in k-mer motifs for patients with severe illness.

6 Dec 2021

SARS-CoV-2 immune memory in mRNA vaccine recipients

Researchers measured SARS-CoV-2–specific antibody, memory B cell, and memory T cell responses in a group of healthy subjects who generated primary immune responses to two doses of mRNA vaccine compared to a group of SARS-CoV-2–recovered vaccines.

6 Dec 2021

Meth use and intimate partner violence drive exhaustion of immune cells in HIV patients

A study of HIV-positive black and Latino men who have sex with men finds the use of methamphetamine combined with intimate partner violence boosted the activity of genes that regulate the body's inflammatory and antiviral functions

6 Dec 2021

Preclinical data shows enhanced T-cell responses & neutralization of SARS-CoV-2 variants with ImmunityBio heterologous vaccination

A new study supports the hypothesis that heterologous vaccination can provide an increased immune response against virus infection, supporting several other studies that have indicated similar events.

5 Dec 2021

In-depth analysis of SARS-CoV-2 specific T cells in unexposed individuals

A new study aimed to analyze SARS-CoV-2 specific T-cells in unexposed individuals.

2 Dec 2021

SARS-CoV-2 infection risks increase with time in fully vaccinated adults

A recent study describes the association between time elapsed since the second dose of the Pfizer-BioNTech BNT162b2 vaccine and risk of COVID-19.

1 Dec 2021

Scientists identify a new therapeutic target for HIV

Scientists in Montreal and London have identified the key role played by transcription factorRORC2 in HIV infection: the molecule attaches itself to parts of the virus's genome yet doesn't prevent it from replicating.

30 Nov 2021

Efficacy and safety of an RBD-based recombinant protein COVID-19 vaccine

A study developed a protein-based subunit vaccine, PHH-1V, that consisted of a recombinant RBD fusion heterodimer of the alpha) and beta variants of SARS-CoV-2.

26 Nov 2021

Safety and immunogenicity of COVID-19 peptide vaccine

In a study published in Nature, researchers from University Hospital Tübingen have been investigating the results from a Phase I trial for a new vaccine against SARS-CoV-2 variants.

25 Nov 2021

SARS-CoV-2 reinfection and the natural immune response

Researchers review available literature on immunity and SARS-CoV-2 infection to elucidate mechanisms behind SARS-CoV-2 immunity and reinfections.

24 Nov 2021

An assessment of potential epitopes in SARS-CoV-2 structural proteins

Researchers utilized multiple bioinformatics resources to identify potent T- and B-cell epitopes of four SARS-CoV-2 structural proteins.

24 Nov 2021

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

A new study published on the medRxiv* preprint server analyzed the trajectories of anti-SARS-CoV-2 antibodies in patients from the RituxiVac study were compared to healthy volunteers. In addition, they investigated the immunogenicity of a third vaccine dose in previously non-responding patients.

23 Nov 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

Time of starting antiretroviral therapy can influence tumor development In HIV patients

HIV patients have an increased risk of developing skin and mucosal cancers, even though HIV is no longer detectable in their blood due to antiretroviral therapy.

23 Nov 2021

CD4 News and Research

Booster vaccination can reduce breakthrough infection risk in HIV patients

Immune responses against SARS-CoV-2 Delta variant after BNT162b2 vaccination in people living with HIV

Increased risk of COVID-19 breakthrough infections in fully vaccinated people with HIV

Exploring SARS-CoV-2 vaccine responsiveness in immunosuppressed patients

Immune response of Pfizer vaccinees who received Moderna or Pfizer booster

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

COVID-19 severity is correlated with T cell receptor repertoire signatures

SARS-CoV-2 immune memory in mRNA vaccine recipients

Meth use and intimate partner violence drive exhaustion of immune cells in HIV patients

Preclinical data shows enhanced T-cell responses & neutralization of SARS-CoV-2 variants with ImmunityBio heterologous vaccination

In-depth analysis of SARS-CoV-2 specific T cells in unexposed individuals

SARS-CoV-2 infection risks increase with time in fully vaccinated adults

Scientists identify a new therapeutic target for HIV

Efficacy and safety of an RBD-based recombinant protein COVID-19 vaccine

Safety and immunogenicity of COVID-19 peptide vaccine

SARS-CoV-2 reinfection and the natural immune response

An assessment of potential epitopes in SARS-CoV-2 structural proteins

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

Time of starting antiretroviral therapy can influence tumor development In HIV patients

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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