Clinical Trial News and Research

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Research ushers in a new era of hope for patients with primary immune thrombocytopenia

More than half of patients in a Phase III clinical trial who received a limited course of the experimental monoclonal antibody ianalumab for primary immune thrombocytopenia (ITP), an autoimmune disorder that can cause life-threatening bleeding, were able to maintain safe platelet counts without serious bleeding episodes for at least one year.

9 Dec 2025

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL).

8 Dec 2025

Combination therapy may boost survival for people with aggressive lymphoma

A new clinical trial suggests that pairing bispecific antibodies and antibody-drug conjugates with CAR T-cell therapy may sharply boost one-year progression-free survival for people with aggressive lymphoma.

8 Dec 2025

Most T-cell/histocyte-rich large B-cell lymphoma patients can safely receive a less toxic treatment

Most patients with a rare and aggressive form of large B-cell lymphoma can safely receive a less toxic treatment than the intensive chemotherapy often used, according to new research from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.

8 Dec 2025

Lubiprostone shows signs of slowing kidney function decline in chronic kidney disease

In adults with stage IIIb–IV chronic kidney disease, the constipation drug lubiprostone did not reduce gut-derived uremic toxins but preserved creatinine-based kidney function over 24 weeks. The benefit was linked to microbiome remodeling, increased polyamine production, and improved mitochondrial function rather than toxin lowering.

8 Dec 2025

NYS Medical Cannabis Program reduces chronic pain patients' reliance on opioids

Adults with chronic pain who participated in New York State's (NYS) Medical Cannabis Program were significantly less likely to require prescription opioids, according to a new study published today in JAMA Internal Medicine and led by researchers at Albert Einstein College of Medicine and Montefiore Health System.

8 Dec 2025

Targeted approach of immunotherapy improves sepsis outcomes

Immunotherapy for sepsis is effective when doctors tailor the treatment precisely to the patient's immune system condition.

8 Dec 2025

JAX wins $30 million contract to create computational "digital twins" of the human heart

Developing new drugs is one of the riskiest and most expensive endeavors in science. Today, The Jackson Laboratory (JAX) announced a bold initiative to improve that trajectory, powered by an up to $30 million contract from the Advanced Research Projects Agency for Health (ARPA-H) Computational ADME-Tox and Physiology Analysis for Safer Therapeutics (CATALYST) program.

8 Dec 2025

New combination treatment offers significant benefits for people with recurring grade 3 astrocytoma

Huntsman Cancer Institute at the University of Utah (the U) participated in a clinical trial that found that a new combination treatment plan helped people with recurring grade 3 astrocytoma, an aggressive form of brain cancer, live longer.

8 Dec 2025

Evidence grows for pirtobrutinib as a safer and effective alternative for CLL and SLL

Pirtobrutinib, a non-covalent Bruton tyrosine kinase (BTK) inhibitor, met the primary endpoint for non-inferiority in terms of overall response rate in the first head-to-head comparison with ibrutinib, a covalent BTK inhibitor.

7 Dec 2025

Many families of children with leukemia face significant financial hardship during treatment

Nearly a third of families with children receiving chemotherapy for acute lymphoblastic leukemia (ALL) – the most common pediatric cancer – develop serious financial difficulties during their child's treatment, including losing 25% or more of their household income and struggling to cover the costs of basic living expenses such as housing, food, and utilities.

7 Dec 2025

Study reveals how viral social interactions shape resistance to antivirals

Interactions among viruses can help them succeed inside their hosts or impart vulnerabilities that make them easier to treat. Scientists are learning the ways viruses mingle inside the cells they infect, as well as the consequences of their socializing.

5 Dec 2025

$New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer$

New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer

A new targeted alpha therapy is showing promise for patients whose thyroid cancer no longer responds to radioactive iodine, the standard beta-emitting treatment. In a first-in-human study, investigators found that a single dose of the alpha-emitting radionuclide 211At (astatine) was both well-tolerated and effective, achieving disease control without molecularly targeted drugs.

5 Dec 2025

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with targeted therapies.

5 Dec 2025

New combination treatment helps people with recurring grade 3 astrocytoma, trial shows

5 Dec 2025

Chronic kidney disease accelerates cognitive decline through heart-brain pathways

A new study published in the American Journal of Physiology - Heart and Circulatory Physiology reveals that chronic kidney disease (CKD) accelerates cognitive decline through interconnected damage to the heart and brain-and that these pathways differ markedly between men and women.

4 Dec 2025

New drug combination shows promise for overcoming resistance in ovarian cancer

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Clinical Trial News and Research

Research ushers in a new era of hope for patients with primary immune thrombocytopenia

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

Combination therapy may boost survival for people with aggressive lymphoma

Most T-cell/histocyte-rich large B-cell lymphoma patients can safely receive a less toxic treatment

Lubiprostone shows signs of slowing kidney function decline in chronic kidney disease

NYS Medical Cannabis Program reduces chronic pain patients' reliance on opioids

Targeted approach of immunotherapy improves sepsis outcomes

JAX wins $30 million contract to create computational "digital twins" of the human heart

New combination treatment offers significant benefits for people with recurring grade 3 astrocytoma

Evidence grows for pirtobrutinib as a safer and effective alternative for CLL and SLL

Many families of children with leukemia face significant financial hardship during treatment

Study reveals how viral social interactions shape resistance to antivirals

New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer

Novel antibody suppresses primary tumor growth and spread of triple-negative breast cancer

New combination treatment helps people with recurring grade 3 astrocytoma, trial shows

Chronic kidney disease accelerates cognitive decline through heart-brain pathways

New drug combination shows promise for overcoming resistance in ovarian cancer

University of Iowa research finds an effective therapy for rare kidney disease in children

Preloading Instacart online grocery carts with healthy ingredients could help improve the diets of families

Breast density alerts may cause confusion and raise anxiety among women

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