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The potential of DNA-based SARS-CoV-2 vaccine candidates

Researchers evaluated the immunogenicity of DNA-based candidate vaccines against SARS-CoV-2 in mice.

28 Jun 2022

COVID-19 can cause metabolism problems by interfering with insulin signaling, study reveals

It has become abundantly clear that coronavirus disease 19 (COVID-19), despite being transmitted by breathing in the SARS-CoV-2 virus, can have harmful effects far beyond the lungs.

27 Jun 2022

Researchers report high rates of new TB infection among adolescents in Tanzania

Published today in PLOS ONE, "Serial T-SPOT.TB responses in Tanzanian adolescents: transient, persistent and irregular conversions" [https://doi.org/10.1371/journal.pone.0268685], investigators from the Geisel School of Medicine and Muhimibili University of Health and Allied Sciences report high rates of new tuberculosis (TB) infection among adolescents in Tanzania.

24 Jun 2022

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

In a recent study posted to the medRxiv* pre-print server, researchers in the United States characterized differential host immune responses in acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) to inform future development of novel biomarkers for both diseases.

23 Jun 2022

Mild COVID causes increase in neurotoxic metabolites

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the blood levels of neurotoxic metabolites in patients with mild coronavirus disease 2019 (COVID-19).

23 Jun 2022

Scientists evaluate JNK inhibitors in treating moderate to severe COVID-19 patients

Scientists have described the clinical outcomes in hospitalized COVID-19 patients who have been treated with JNK inhibitors together with standard of care.

22 Jun 2022

The possible immune-mediated mechanisms causing CNS alterations during and post-acute SARS-CoV-2 infection

In a recent review published in Immunity, researchers explored potential mechanisms of neuro-immune pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

22 Jun 2022

Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

A recent study published in the Cell Reports journal analyzed immune ecology at the placenta in mild or asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy.

22 Jun 2022

Researchers compare the development and persistence of antibody and T-cell responses elicited by the mRNA BNT162b2 vaccine or SARS-CoV-2 infection

Researchers comparatively assessed the generation of B lymphocyte-mediated antibody responses and T lymphocyte-mediated cellular responses between mRNA BNT162b vaccinees and mild COVID-19 patients.

21 Jun 2022

Implications of impaired type I interferon immunity and increasing COVID-19 severity

Researchers demonstrated that impaired type I interferon immunity is associated with increasing coronavirus disease 2019 severity.

20 Jun 2022

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

In a recent study posted to the bioRxiv* pre-print server, researchers at Cornell University College of Veterinary Medicine and the University of Illinois Urbana-Champaign compared the infection dynamics, pathogenicity, and tissue tropism of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in adult cats.

17 Jun 2022

How does gut microbiota impact mental health in 18–25s?

In a recently published article in the International Journal of Molecular Sciences, scientists have described the importance of the gut-brain-microbiota axis in establishing optimal mental health in emerging adulthood (ages 18–25).

16 Jun 2022

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

A new study explores the role of non-structural protein 1 (NSP1) in SARS-CoV-2 infection and pathogenesis.

16 Jun 2022

Type I interferons play crucial role in fending off SARS-CoV-2

Researchers investigated whether individuals with breakthrough infections of COVID-19 pneumonia demonstrated normal antibody responses to vaccinations and whether they harbored type I interferon-neutralizing auto-antibodies.

16 Jun 2022

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

In a recent study posted to the bioRxiv* pre-print server, researchers illustrated the cryo-electron microscopic (cryo-EM) structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein in lipid nanodiscs to 3.5 angstroms (Å) resolution.

16 Jun 2022

Multiomics identifies genomic risk factors for COVID-19

In a recent Cell Systems study, researchers utilized the RefMap machine learning algorithm to correlate known genomic variations for severe COVID-19 obtained from large-scale genome-wide association studies (GWAS) with single-cell multiome profiling of human lungs.

16 Jun 2022

Scientists characterize type I IFN response during SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, Canadian researchers assessed the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on interferon (IFN) response.

15 Jun 2022

New test can tell if you are immune to SARS-CoV-2

In a recent study published in the journal Nature Biotechnology, an international team of researchers developed and evaluated quantitative polymerase chain reaction (qPCR)-based assays to quantify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific functional T cell immunity.

15 Jun 2022

Researchers discover specific genetic signals in people who develop severe COVID-19

Researchers from the University of Sheffield and Stanford University in the US have discovered there are specific genetic signals in people who develop severe coronavirus infection.

14 Jun 2022

Animal study suggests intranasal COVID vaccine delivery more efficient than intramuscular

In a recent study published in the journal PNAS, researchers demonstrated higher comparative efficacy of the intranasal (IN) route of coronavirus disease 2019 (COVID-19) vaccine administration versus intramuscular route in mice.

12 Jun 2022

Interferon News and Research

The potential of DNA-based SARS-CoV-2 vaccine candidates

COVID-19 can cause metabolism problems by interfering with insulin signaling, study reveals

Researchers report high rates of new TB infection among adolescents in Tanzania

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

Mild COVID causes increase in neurotoxic metabolites

Scientists evaluate JNK inhibitors in treating moderate to severe COVID-19 patients

The possible immune-mediated mechanisms causing CNS alterations during and post-acute SARS-CoV-2 infection

Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

Researchers compare the development and persistence of antibody and T-cell responses elicited by the mRNA BNT162b2 vaccine or SARS-CoV-2 infection

Implications of impaired type I interferon immunity and increasing COVID-19 severity

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

How does gut microbiota impact mental health in 18–25s?

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

Type I interferons play crucial role in fending off SARS-CoV-2

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

Multiomics identifies genomic risk factors for COVID-19

Scientists characterize type I IFN response during SARS-CoV-2 infection

New test can tell if you are immune to SARS-CoV-2

Researchers discover specific genetic signals in people who develop severe COVID-19

Animal study suggests intranasal COVID vaccine delivery more efficient than intramuscular

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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