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Study shows how early-life BPA exposure leads to NAFLD in adulthood

Exposure during infancy to the common plasticizer bisphenol A "hijacks" and reprograms genes in the liver of newborn rats, leading to nonalcoholic fatty liver disease in adulthood.

2 Apr 2017

Study reveals high-resolution view of Zika viral life cycle within infected cells

New research reveals a high-resolution view of the Zika viral life cycle within infected cells and shows dramatic changes in the cell's architecture throughout the infection process. This novel perspective may lead to the development of new vaccines and treatments.

30 Mar 2017

UAB chemists design microcapsules for guided drug delivery system to target solid tumors

Chemists at the University of Alabama at Birmingham have designed triple-threat cancer-fighting polymer capsules that bring the promise of guided drug delivery closer to preclinical testing.

30 Mar 2017

Researchers use stem cells to model different genetic scenarios that underlie neurologic disease

Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms.

30 Mar 2017

NUS researchers uncover hidden vulnerabilities on surface of dengue virus

A team of researchers from the National University of Singapore has uncovered hidden vulnerabilities on the surface of the dengue virus. This novel discovery means that scientists can now develop strategies to target these weak spots for treatment of dengue, and possibly other closely related diseases like Zika, influenza and chikungunya.

30 Mar 2017

Rare ‘beneficial’ genetic mutations may provide clues to preventing heart attacks

Natural genetic changes can put some people at high risk of certain conditions, such as breast cancer, Alzheimer's disease or high blood pressure. But in rare cases, genetic errors also can have the opposite effect, protecting individuals with these helpful genetic mistakes from developing common diseases.

30 Mar 2017

Study shows inhibition of transgelin prevents vasculogenic mimicry in breast cancer

An article published in Experimental Biology and Medicine identifies a new signaling pathway involved in breast cancer cell growth. The study, led by Dr. Chan-Wha Kim, from the Department of Biotechnology at Korea University in Seoul, reports that inhibition of the actin-binding protein transgelin prevents vasculogenic mimicry (VM), a process that provides tumor cells with the nutrients required for growth.

29 Mar 2017

Research findings open door to new class of analgesics for treating neuropathic pain

New research published online in The FASEB Journal suggests that a novel therapeutic target called LPCAT2 may prove effective against pain that is not receptive to the current treatments.

29 Mar 2017

City of Hope researchers to highlight basic cancer research and population studies at AACR meeting

City of Hope, a world-renowned independent research and cancer and diabetes treatment center, will highlight a variety of basic research and population studies at the annual meeting of the American Association for Cancer Research at the Walter E. Washington Convention Center in Washington, D.C., April 1 to 5.

28 Mar 2017

Study highlights importance of long-term research in bringing new cancer therapies to market

New drugs to treat cancer that are now emerging are the end products of research begun in the 1970s and '80s, a new study by Bentley University has found, demonstrating the importance of long-term research in bringing new therapies to market.

28 Mar 2017

Scientists show p300 protein may stop MDS from developing into leukemia

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that p300, a protein that increases gene expression by attaching acetyl molecules to DNA, may stop myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). The study was published in the journal Leukemia.

27 Mar 2017

Research findings offer potential explanation for opioid-induced itching

Opioids have long been an important tool in the world of pain management, but the side effects of these drugs - from addiction and respiratory failure to severe itching and dizziness, can be overwhelming.

27 Mar 2017

Scientists crack crystal structure of entire ZIKV NS5 protein

Zika virus (ZIKV), which causes Zika virus disease, is spread to people primarily through the bite of an infected Aedes aegypti or Aedes albopictus mosquito. An infected pregnant woman can pass ZIKV to her fetus during pregnancy or around the time of birth. Sex is yet another way for infected persons to transmit ZIKV to others.

27 Mar 2017

Major grant funds research effort that seeks to understand complexity of invasive cancer

A $9.5 million, five-year grant from the National Cancer Institute (NCI) will fund an intensive multidisciplinary research effort that seeks to better understand how cancer cells reach an aggressive state and begin to damage surrounding tissue.

25 Mar 2017

Researchers pinpoint Jumonji protein as key to Ewing's Sarcoma spread

By the time Ewing's Sarcoma is diagnosed, primarily in teens and young adults, it has often spread from its primary site to other parts of the body, making it difficult to treat.

24 Mar 2017

MRI brain scans may help clinicians decide between CBT and drug treatment for depression

Researchers from Emory University have found that specific patterns of activity on brain scans may help clinicians identify whether psychotherapy or antidepressant medication is more likely to help individual patients recover from depression.

24 Mar 2017

Research suggests novel strategy to target genetic anomaly in prostate cancers

New research suggests a novel strategy to target a genetic anomaly that occurs in half of all prostate cancers.

24 Mar 2017

Study shows efficacy of biologics for mucosal healing in Crohn's disease and ulcerative colitis

Although anti-inflammatory treatments are quite effective at reducing symptoms in patients with Crohn's disease and ulcerative colitis, the mucosal lining of the intestine often remains ulcerated, and many patients still ultimately require surgery.

22 Mar 2017

Penn researcher wins Scientific Innovations Award from Chicago-based Brain Research Foundation

James Eberwine, PhD, the Elmer Holmes Bobst Professor of Systems Pharmacology and Translational Therapeutics at the Perelman School of Medicine at the University of Pennsylvania, has received the 2017 Scientific Innovations Award from the Chicago-based Brain Research Foundation, which supports research for preventing and treating neurological diseases.

22 Mar 2017

Researchers develop new method that uses gene editing to find cancer's weak spots

Genetic mutations that cause cancer also weaken cancer cells, creating an opportunity for researchers to develop drugs that will selectively kill them, while sparing normal cells.

20 Mar 2017

Therapeutics News and Research

Study shows how early-life BPA exposure leads to NAFLD in adulthood

Study reveals high-resolution view of Zika viral life cycle within infected cells

UAB chemists design microcapsules for guided drug delivery system to target solid tumors

Researchers use stem cells to model different genetic scenarios that underlie neurologic disease

NUS researchers uncover hidden vulnerabilities on surface of dengue virus

Rare ‘beneficial’ genetic mutations may provide clues to preventing heart attacks

Study shows inhibition of transgelin prevents vasculogenic mimicry in breast cancer

Research findings open door to new class of analgesics for treating neuropathic pain

City of Hope researchers to highlight basic cancer research and population studies at AACR meeting

Study highlights importance of long-term research in bringing new cancer therapies to market

Scientists show p300 protein may stop MDS from developing into leukemia

Research findings offer potential explanation for opioid-induced itching

Scientists crack crystal structure of entire ZIKV NS5 protein

Major grant funds research effort that seeks to understand complexity of invasive cancer

Researchers pinpoint Jumonji protein as key to Ewing's Sarcoma spread

MRI brain scans may help clinicians decide between CBT and drug treatment for depression

Research suggests novel strategy to target genetic anomaly in prostate cancers

Study shows efficacy of biologics for mucosal healing in Crohn's disease and ulcerative colitis

Penn researcher wins Scientific Innovations Award from Chicago-based Brain Research Foundation

Researchers develop new method that uses gene editing to find cancer's weak spots

Industry Focus eBook - Biotechnology (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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