Tumor News and Research

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'Synthetic lethality' could be exploited for cancer therapy

A Ludwig Cancer Research study has identified a new instance in which the simultaneous mutation of two nonessential genes--neither of which is on its own vital to cell survival--can cause cancer cell death.

28 Jul 2020

Study identifies phosphorylation-based biomarkers to guide cancer therapy

Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients.

28 Jul 2020

Study reveals new mechanism that fuels cancer adaptation

Collaborative Cancer Research UK-funded studies from University of Oxford researchers have uncovered a new mechanism by which cancer cells adapt to the stresses they encounter as they grow and respond to therapies.

28 Jul 2020

Federated learning approach can help answer different medical questions

To answer medical questions that can be applied to a wide patient population, machine learning models rely on large, diverse datasets from a variety of institutions.

28 Jul 2020

Study could lead to treatments that prevent deadly metastasis

Tiny finger-like projections called filopodia drive invasive behavior in a rare subset of lung cancer cells, researchers at Winship Cancer Institute of Emory University have found.

28 Jul 2020

Simultaneous mutation of two nonessential genes can cause cancer cell death

A Ludwig Cancer Research study has identified a new instance in which the simultaneous mutation of two nonessential genes - neither of which is on its own vital to cell survival - can cause cancer cell death.

28 Jul 2020

Exploiting 'synthetic lethality' to identify cancer targets

With advances in genome sequencing, cancer treatments have increasingly sought to leverage the idea of "synthetic lethality," exploiting cancer-specific genetic defects to identify targets that are uniquely essential to the survival of cancer cells.

28 Jul 2020

Novel label-free imaging method can differentiate active T cells from those off duty

T cells are the immune soldiers at the frontlines of the battle with infiltrating pathogens that seek to cause disease. A new study published in Nature Biomedical Engineering describes a novel label-free imaging technique that can differentiate active T cells from those off duty.

27 Jul 2020

Pathological regression of lymph nodes better predicts survival in esophageal cancer patients

A group of researchers led by Osaka University established a new pathological grading system to evaluate the therapeutic effect of neoadjuvant chemotherapy for metastatic lymph nodes removed in esophageal cancer surgery, demonstrating that the system predicts recurrence and prognosis in EC patients better than conventional systems.

27 Jul 2020

Study reveals manifold applications of cytokine transcriptional response modules in COVID-19

In a recent bioRxiv* study, UK researchers used interleukin modules to investigate the pathology of coronavirus disease (COVID-19).

27 Jul 2020

Researchers use new approach to unravel the mechanisms that lie behind tetraploidy

Cell division is a fundamental process that organisms need to reproduce, grow, and make repairs. But when an error disrupts this complex biological process, cellular abnormalities can lead to diseases, such as cancer, where cells are enabled to grow and divide out of control.

25 Jul 2020

Non-invasive urine test being offered free to the NHS to help clear bladder cancer diagnoses backlog

A HIGHLY accurate urine test which can rule out bladder cancer with a negative-predictive value of 99% using a hospital laboratory’s standard ELISA testing equipment is today being offered free to the NHS to help urologists clear the backlog of people waiting for a diagnosis and monitoring as a result of COVID-19 hospital closures.

25 Jul 2020

New model may explain why certain cancer cells are resistant to therapy

Cancer's knack for developing resistance to chemotherapy has long been a major obstacle to achieving lasting remissions or cures.

24 Jul 2020

Epigenomic modifications play key role in the development of lung tumors

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

23 Jul 2020

Mouse orthotopic model was used to determine personalized therapy for relapse sarcoma

A team from IDIBELL and ICO, using a mouse orthotopic model, conducted a real-time personalized oncology study to test the best therapeutic option to treat a type of relapse sarcoma. Malignant Peripheral Nerve Sheath Tumor are very aggressive and do not usually have a good prognosis, especially if complete surgical excision cannot be achieved.

23 Jul 2020

Combining two immunotherapies into a single treatment found to be more effective

Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patient's immune system to attack cancer. But immunotherapies don't work in all patients, and researchers have been searching for ways to increase their effectiveness.

23 Jul 2020

Hollings Cancer Center researcher receives NCI grants for cancer immunotherapy studies

Hollings Cancer Center researcher Jessica Thaxton, Ph.D., is the recipient of two grants totaling $3.4 million from the National Cancer Institute for her work in cancer immunotherapy and cell stress, one of which is part of the Cancer Moonshot Initiative on immunometabolism.

23 Jul 2020

Gene signature explains why 18F-FDG imaging performs better for PSMA-suppressed prostate cancer patients

Scientists have uncovered the genomic signature to explain why 18F-FDG imaging performs better than PSMA-targeted imaging for prostate cancer patients with low or no expression of the prostate-specific membrane antigen (PSMA).

23 Jul 2020

Mouse model of pancreatic cancer recreates two subtypes of human disease

Scientists at Cold Spring Harbor Laboratory (CSHL) have created the first mouse model of pancreatic cancer that recreates two subtypes of the human disease.

23 Jul 2020

Ultivue and OracleBio partner to help advance personalized tumor characterization and clinical oncology research using multiplex immunofluorescence

Ultivue and OracleBio partner to help further insights and advance personalized tumor characterization in translational and clinical oncology research.

From Ultivue 23 Jul 2020

Tumor News and Research

'Synthetic lethality' could be exploited for cancer therapy

Study identifies phosphorylation-based biomarkers to guide cancer therapy

Study reveals new mechanism that fuels cancer adaptation

Federated learning approach can help answer different medical questions

Study could lead to treatments that prevent deadly metastasis

Simultaneous mutation of two nonessential genes can cause cancer cell death

Exploiting 'synthetic lethality' to identify cancer targets

Novel label-free imaging method can differentiate active T cells from those off duty

Pathological regression of lymph nodes better predicts survival in esophageal cancer patients

Study reveals manifold applications of cytokine transcriptional response modules in COVID-19

Researchers use new approach to unravel the mechanisms that lie behind tetraploidy

Non-invasive urine test being offered free to the NHS to help clear bladder cancer diagnoses backlog

New model may explain why certain cancer cells are resistant to therapy

Epigenomic modifications play key role in the development of lung tumors

Mouse orthotopic model was used to determine personalized therapy for relapse sarcoma

Combining two immunotherapies into a single treatment found to be more effective

Hollings Cancer Center researcher receives NCI grants for cancer immunotherapy studies

Gene signature explains why 18F-FDG imaging performs better for PSMA-suppressed prostate cancer patients

Mouse model of pancreatic cancer recreates two subtypes of human disease

Ultivue and OracleBio partner to help advance personalized tumor characterization and clinical oncology research using multiplex immunofluorescence

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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