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Researchers discover key step to stem bleeding, reduce obstruction in blood flow during clot formation

Red blood cells are the body's true shape shifters, perhaps the most malleable of all cell types, transforming - among many other forms -- into compressed discs capable of going through capillaries with diameters smaller than the blood cell itself.

10 Jan 2014

Discovery opens new therapeutic avenue for chronic skin condition affecting millions

Researchers from the La Jolla Institute for Allergy and Immunology have revealed a critical player in the cellular interactions leading to eczema - a chronic inflammatory skin condition affecting more than 14 million U.S. children and adults.

10 Jan 2014

Antipsychotic medication can actively combat cells of difficult-to-treat form of ALL

In a prime example of finding new uses for older drugs, studies in zebrafish show that a 50-year-old antipsychotic medication called perphenazine can actively combat the cells of a difficult-to-treat form of acute lymphoblastic leukemia. The drug works by turning on a cancer-suppressing enzyme called PP2A and causing malignant tumor cells to self-destruct.

9 Jan 2014

Study provides details to help scientists design better vaccines for Plasmodium vivax

A form of malaria common in India, Southeast Asia and South America attacks human red blood cells by clamping down on the cells with a pair of proteins, new research at Washington University School of Medicine in St. Louis has revealed.

9 Jan 2014

Gastric bypass and cardiovascular disease risk: an interview with Dr. Brethauer, Cleveland Clinic

Gastric bypass surgery is a type of bariatric operation that results in weight loss and stimulates metabolic effects that treat diabetes and other cardiovascular risk factors such as diabetes, high cholesterol, and hypertension.

9 Jan 2014

Trevena doses first patient in TRV027 Phase 2b trial for acute heart failure

Trevena, Inc., a clinical stage pharmaceutical company involved in the discovery and development of G-protein coupled receptor biased ligands, announced today initiation of dosing in BLAST-AHF, the Company's randomized, multi-center Phase 2b trial of TRV027 in patients with acute heart failure.

9 Jan 2014

Subset of TH17 cells linked to inflammation in Crohn’s disease patients, find TSRI scientists

Two-thirds to three-quarters of the estimated 700,000 Americans living with Crohn’s disease, an autoimmune condition that can disrupt the entire gastrointestinal tract, will require surgery at some point during their life. Patients and physicians often turn to this surgical intervention after a patient develops resistance to current treatments, such as steroids.

9 Jan 2014

TSRI scientists identify small subset of immune cells that play major role in development of Crohn's disease

Two-thirds to three-quarters of the estimated 700,000 Americans living with Crohn's disease, an autoimmune condition that can disrupt the entire gastrointestinal tract, will require surgery at some point during their life.

9 Jan 2014

Researchers use stem cells to study bone disorders from patients afflicted with genetic bone disease

Researchers have developed a new way to study bone disorders and bone growth, using stem cells from patients afflicted with a rare, genetic bone disease.

9 Jan 2014

Research: New target for treating Huntington's and Parkinson's disease

Research from Western University (London, Canada) has revealed a possible new target for treating movement disorders such as Huntington's disease (HD) and Parkinson's disease. Stephen Ferguson, PhD, a scientist at Western's Robarts Research Institute, and Fabiola Ribeiro, PhD, of the Universidade Federal de Minas Gerais in Brazil found a definite improvement in motor behaviors in a HD mouse model when one of the major neurotransmitters in the brain, called Metabotropic Glutamate Receptor 5 (mGluR5) was deleted.

9 Jan 2014

MicroRNA biomarker shows promise in predicting treatment response of ovarian cancer

Researchers at Case Western Reserve University have identified a microRNA biomarker that shows promise in predicting treatment response in the most common form of ovarian cancer - a breakthrough that has the potential to improve outcomes for patients with the disease.

9 Jan 2014

ProteinSimple introduces revolutionary re-invention of Western blot

ProteinSimple today introduced Wes, another revolutionary re-invention of the Western blot. Wes is the bold evolution of the popular Simple Western family of instruments, delivering simplicity and performance like no product before it. With just 30 minutes of sample prep, Wes will analyze up to 25 samples in under 3 hours and he will do it all for less than the price of a high-end Western imager.

From ProteinSimple 8 Jan 2014

C. parvum and cryptosporidiosis: an interview with Dr. Momar Ndao, McGill University

Cryptosporidium parvum is one of the most common enteropathogens to affect humans in the world. The protozoan parasite causes a gut infection referred to as cryptosporidiosis.

8 Jan 2014

Study compares relative rate of molecular evolution between humans and chimps with their lice

A new study compares the relative rate of molecular evolution between humans and chimps with that of their lice. The researchers wanted to know whether evolution marches on at a steady pace in all creatures or if subtle changes in genes - substitutions of individual letters of the genetic code - occur more rapidly in some groups than in others.

8 Jan 2014

Study raises hopes for new drugs to treat brain disorders associated with neurotransmitter imbalance

Although drugs have been developed that inhibit the imbalance of neurotransmitters in the brain - a condition which causes many brain disorders and nervous system diseases - the exact understanding of the mechanism by which these drugs work has not yet been fully understood.

8 Jan 2014

Research findings could affect how drugs are developed to treat autoimmune diseases

Researchers at Johns Hopkins have zoomed in on what is going on at the molecular level when the body recognizes and defends against an attack of pathogens, and the findings, they say, could influence how drugs are developed to treat autoimmune diseases.

8 Jan 2014

Researchers explore molecular level changes when body recognizes, defends against pathogens

8 Jan 2014

Professor receives ALSF grant to develop cancer vaccine technology that help children to have healthy life

In 2004, a form of cancer known as neuroblastoma claimed the life of Alexandra (Alex) Scott, a little girl who gained national attention for using her lemonade stand to raise money for cancer research.

8 Jan 2014

Cornell biomedical engineers identify new way to destroy metastasizing cancer cells

Cornell biomedical engineers have discovered a new way to destroy metastasizing cancer cells traveling through the bloodstream - lethal invaders that are linked to almost all cancer deaths - by hitching cancer-killing proteins along for a ride on life-saving white blood cells.

8 Jan 2014

Added benefit of dabrafenib not proven

Dabrafenib has been approved in Germany since August 2013 for the treatment of advanced melanoma. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products, the German Institute for Quality and Efficiency in Health Care examined whether this new drug offers an added benefit over the appropriate comparator therapy.

7 Jan 2014

G Protein News and Research

Researchers discover key step to stem bleeding, reduce obstruction in blood flow during clot formation

Discovery opens new therapeutic avenue for chronic skin condition affecting millions

Antipsychotic medication can actively combat cells of difficult-to-treat form of ALL

Study provides details to help scientists design better vaccines for Plasmodium vivax

Gastric bypass and cardiovascular disease risk: an interview with Dr. Brethauer, Cleveland Clinic

Trevena doses first patient in TRV027 Phase 2b trial for acute heart failure

Subset of TH17 cells linked to inflammation in Crohn’s disease patients, find TSRI scientists

TSRI scientists identify small subset of immune cells that play major role in development of Crohn's disease

Researchers use stem cells to study bone disorders from patients afflicted with genetic bone disease

Research: New target for treating Huntington's and Parkinson's disease

MicroRNA biomarker shows promise in predicting treatment response of ovarian cancer

ProteinSimple introduces revolutionary re-invention of Western blot

C. parvum and cryptosporidiosis: an interview with Dr. Momar Ndao, McGill University

Study compares relative rate of molecular evolution between humans and chimps with their lice

Study raises hopes for new drugs to treat brain disorders associated with neurotransmitter imbalance

Research findings could affect how drugs are developed to treat autoimmune diseases

Researchers explore molecular level changes when body recognizes, defends against pathogens

Professor receives ALSF grant to develop cancer vaccine technology that help children to have healthy life

Cornell biomedical engineers identify new way to destroy metastasizing cancer cells

Added benefit of dabrafenib not proven

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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