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Promising new drug may offer effective treatment for heart failure patients

Heart failure patients who are getting by on existing drug therapies can look forward to a far more effective medicine in the next five years or so, thanks to University of Alberta researchers.

8 Mar 2017

SETD8 enzyme protects against cellular senescence, research reveals

An enzyme that blocks cellular senescence and its mechanisms has been discovered by a research team from Kumamoto University, Japan. They found that a reduction of the enzyme SETD8, which regulates cell proliferation and gene function, results in the promotion of cell aging features.

8 Mar 2017

IU study reveals new compounds with potential to boost enzyme that could protect against dementia

A study by Indiana University researchers has identified 24 compounds -- including caffeine -- with the potential to boost an enzyme in the brain shown to protect against dementia.

7 Mar 2017

Diabetes medication could be effective therapy for aggressive type of breast cancer

Researchers in China have discovered that a metabolic enzyme called AKR1B1 drives an aggressive type of breast cancer.

7 Mar 2017

New technique can effectively identify cancer-causing substances in urine or blood

A team of researchers, led by Professor Yoon-Kyoung Cho of Life Science at UNIST has recently developed a new technique that effectively identifies cancer-causing substances in the urine or blood.

7 Mar 2017

Study identifies protein that may offer protection against heart disease

A protein found in the heart that is known to be involved in cellular stress responses in cancer cells is now believed to play a critical role in the ability of cardiac cells to combat heart disease and recover from a heart attack.

6 Mar 2017

Researchers uncover new genetic clues linked to autoimmune kidney disease

Researchers have uncovered new genetic clues to understanding IgA nephropathy (IgAN), or Berger's disease, an autoimmune kidney disease and a common cause of kidney failure.

6 Mar 2017

SLU study findings suggest new method to suppress LDL cholesterol

In a paper published in Biochemical Pharmacology, Saint Louis University researchers examined the way a nuclear receptor called REV-ERB is involved in regulating cholesterol metabolism.

6 Mar 2017

UAlberta scientists use nanomachines for improved disease detection and drug delivery

University of Alberta scientists have pulled into the lead in a race to use nanomachines for improved disease detection and drug delivery in patients.

6 Mar 2017

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

Working with yeast and human cells, researchers at Johns Hopkins say they have discovered an unexpected route for cells to eliminate protein clumps that may sometimes be the molecular equivalent of throwing too much or the wrong trash into the garbage disposal.

3 Mar 2017

Research provides insights on how pathogens escape process of autophagy

Our immune system has various ways to deal with threats from the outside like pathogens. One of the defence mechanisms is a process called autophagy.

3 Mar 2017

Rheumatoid arthritis drug blocks metabolic pathway, reduces breast cancer tumors in mice

Mount Sinai researchers have discovered that a rheumatoid arthritis drug can block a metabolic pathway that occurs in tumors with a common cancer-causing gene mutation, offering a new possible therapy for aggressive cancers with few therapeutic options, according to a study to be published in Cancer Discovery.

3 Mar 2017

Metabolic vulnerability in triple-negative breast cancer cells may help quell chemotherapy resistance

A team of researchers led by Alex Toker of the Ludwig Center at Harvard has discovered a metabolic weakness in triple-negative breast cancer cells that may be exploited to quell their resistance to chemotherapy.

2 Mar 2017

Researcher examines scarring process in hope of preventing chronic lung transplant rejection

For patients affected by lung diseases such as pulmonary fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and others, cures for their diseases are incredibly rare, if not nonexistent.

2 Mar 2017

Scientists reveal new mRNA method to deliver safe, cost-effective therapeutic antibodies

Using antibodies to treat disease has been one of the great success stories of early 21st-century medicine. Already five of the ten top-selling pharmaceuticals in the United States are antibody products. But antibodies are large, complex proteins that can be expensive to manufacture.

2 Mar 2017

Cholesterol-processing enzyme could be therapeutic target to stave off neurologic diseases

An enzyme that helps break down cholesterol may also be a therapeutic target to stave off neurologic diseases, including Alzheimer's and a rare genetic disorder, according to a new study published in the Journal of Biological Chemistry.

2 Mar 2017

Compound from soil bacteria could translate into new drug lead for TB

A new treatment for tuberculosis (TB) is set to be developed using compounds derived from bacteria that live in soil - according an international collaboration of researchers, including the University of Warwick.

1 Mar 2017

Novel NMR spectroscopy platform holds potential to revolutionize drug development practices

Implementation of a new nuclear magnetic resonance spectroscopy platform will provide professors Nicolas Doucet and Steven LaPlante of Centre INRS-Institut Armand-Frappier with a powerful new tool for conducting an ambitious research program aimed at identifying new therapeutic molecules.

28 Feb 2017

Biologists develop new way to inhibit cancer cell cleanup mechanism

The genomes of cancer cells--cells that do not obey signals to stop reproducing--are riddled with genetic mutations, causing them inadvertently to make many dysfunctional proteins.

28 Feb 2017

Scientists discover how genetic mutation disarms tumor-suppressing BRCA1 proteins in breast cancer

Of the more than 3 million people with breast cancer in the United Stated, about 10 percent carry an inherited mutation in their BRCA1 gene. In health, the gene is responsible for suppressing tumors. In disease, the gene goes terribly awry.

28 Feb 2017

Enzyme News and Research

Promising new drug may offer effective treatment for heart failure patients

SETD8 enzyme protects against cellular senescence, research reveals

IU study reveals new compounds with potential to boost enzyme that could protect against dementia

Diabetes medication could be effective therapy for aggressive type of breast cancer

New technique can effectively identify cancer-causing substances in urine or blood

Study identifies protein that may offer protection against heart disease

Researchers uncover new genetic clues linked to autoimmune kidney disease

SLU study findings suggest new method to suppress LDL cholesterol

UAlberta scientists use nanomachines for improved disease detection and drug delivery

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

Research provides insights on how pathogens escape process of autophagy

Rheumatoid arthritis drug blocks metabolic pathway, reduces breast cancer tumors in mice

Metabolic vulnerability in triple-negative breast cancer cells may help quell chemotherapy resistance

Researcher examines scarring process in hope of preventing chronic lung transplant rejection

Scientists reveal new mRNA method to deliver safe, cost-effective therapeutic antibodies

Cholesterol-processing enzyme could be therapeutic target to stave off neurologic diseases

Compound from soil bacteria could translate into new drug lead for TB

Novel NMR spectroscopy platform holds potential to revolutionize drug development practices

Biologists develop new way to inhibit cancer cell cleanup mechanism

Scientists discover how genetic mutation disarms tumor-suppressing BRCA1 proteins in breast cancer

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Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo